Offspring sex and risk of epithelial ovarian cancer: a multinational pooled analysis of 12 case–control studies

Abstract

We are grateful to the family and friends of Kathryn Sladek Smith for their generous support of the Ovarian Cancer Association Consortium through their donations to the Ovarian Cancer Research Fund. We thank the study participants, doctors, nurses, research staff, clinical and scientific collaborators, health care providers, and health information sources who have contributed to the many studies contributing to this manuscript. Acknowledgements for individual studies: AUS: The AOCS also acknowledges the cooperation of the participating institutions in Australia, and the contribution of the study nurses, research assistants and all clinical and scientific collaborators. The complete AOCS Study Group can be found at www.aocstudy.org. We would like to thank all of the women who participated in this research program; CON: The cooperation of the 32 Connecticut hospitals, including Stamford Hospital, in allowing patient access, is gratefully acknowledged. This study was approved by the State of Connecticut Department of Public Health Human Investigation Committee. Certain data used in this study were obtained from the Connecticut Tumor Registry in the Connecticut Department of Public Health. The authors assume full responsibility for analyses and interpretation of these data; GER: The German Ovarian Cancer Study (GER) thank Sabine Behrens for competent technical assistance; UKO: We particularly thank I.

What is new about ovarian malignancies?

“…The sex of the offspring was not linked with EOC risk for serous, clear cell, and endometrioid histotypes. However, bearing male offspring was associated with lower protection against mucinous histotype, but the male sex appeared to have no significant relation to this kind of EOC [ 16 ].…”