Oil-in-Oil-Emulsions with Enhanced Substantivity for the Treatment of Chronic Skin Diseases

Lunter, Dominique Jasmin; Rottke, Michael; Daniels, Rolf

doi:10.1002/jps.23944

Cited by 19 publications

(14 citation statements)

References 20 publications

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“…The water resistance testing was based on a previous study with pig ear skin [31] , but strikingly modified. The residence time for up to 8 h of modified and unmodified silicone oils was determined.…”

Section: Methodsmentioning

confidence: 99%

Thiolated silicone oil: Synthesis, gelling and mucoadhesive properties

et al. 2015

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Section: Methodsmentioning

confidence: 99%

Thiolated silicone oil: Synthesis, gelling and mucoadhesive properties

et al. 2015

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“…The Department of Pharmaceutical Technology is registered for the use of animal products at the District Office of Tuebingen (registration number: DE 08 416 1052 21). In ex vivo permeation studies, the skin was prepared according to previous studies [ 55 , 56 ]. Briefly, fresh pig ears were washed with isotonic saline using cotton balls and after postauricular skin excision, wrapped in aluminium foil and stored at −30 °C until further use.…”

Section: Methodsmentioning

confidence: 99%

Influence of PVA Molecular Weight and Concentration on Electrospinnability of Birch Bark Extract-Loaded Nanofibrous Scaffolds Intended for Enhanced Wound Healing

Mwiiri

Daniels

2020

Molecules

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Triterpenes from the outer bark of birch (TE) are known for various pharmacological effects including enhanced wound healing. Apart from an already authorized oleogel, electrospun nanofiber mats containing these triterpenes in a polyvinyl alcohol (PVA) matrix appear to be an advantageous application form. The effects of PVA molecular weight and concentration on the fiber morphology have been investigated. Three different molecular weights of PVA ranging from 67 to 186 kDa were used. The concentration of PVA was varied from 5 to 20 wt%. Polymer solutions were blended with colloidal dispersions of birch bark extract at a weight ratio of 60:40 (wt.%). The estimated viscosity of polymer solutions was directly linked to their concentration and molecular weight. In addition, both pure and blended solutions showed viscoelastic properties with a dominant viscous response in the bulk. Fiber morphology was confirmed using scanning electron microscopy (SEM). Both polymer concentration and molecular weight were found to be significant factors affecting the diameter of the fibers. Fiber diameter increased with a higher molecular weight and polymer concentration as more uniform fibers were obtained using PVA of higher molecular weight (146–186 kDa). In vitro drug release and ex vivo permeation studies indicated a faster drug release of betulin from electrospun scaffolds with lower PVA molecular weight. Our research suggests that the fabricated TE-loaded PVA electrospun dressings represent potential delivery systems of TE for wound care applications.

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“…Fresh pig ear skin samples were prepared according to literature . In brief, ears were washed with isotonic saline, wrapped into aluminium foil and stored at −30°C.…”

Section: Methodsmentioning

confidence: 99%