OKT3 monoclonal antibody inhibits cytotoxic T lymphocyte mediated cell lysis

A CD3-Specific Antibody Reduces Cytokine Production and Alters Phosphoprotein Profiles in Intestinal Tissues From Patients With Inflammatory Bowel Disease

“…OKT3 induces a cytokine storm, which obviates its use in the treatment of autoimmune conditions [2][3][4] . This cytokine storm is a consequence of the cross-linking of the CD3/T cell receptor (TcR) on T cells, coupled with Fc binding to the Fc gamma Receptor (FcR) on other immune cells.…”

Monoclonal Antibodies for Clinical Investigation of Human T Lymphocytes

“…*"' INTERNATIONAL IOURNAL OF DERMATOLOCY March 1983 Vol. 22 Platt et al examined interstitial mononuclear cell populations in renal graft rejection in tissue sections and reported that most infiltrating cells are T cells, the greater proportion of which are OKT8+ cells. They postulated that these OKT8-I-cells may play an important role in mediating renal graft rejection,^'…”

Peripheral blood of patients with cutaneous T‐cell lymphoma: studies using monoclonal antibodies

“…The precursors and effectors of cytotoxic T-cells directed against allogcnic HLA-A & -B positive target cells and ultercd-scH antigens are contained in this subset (Biddison et al 1981). OKT8 blocks the lysis of target cells by cytotoxic T-cells suggesting that (he antigen recognized by OKT8 may be associated with the recognition site of killer T-cells (Chang & Gringrass 1981b). OKT8positive cells function in the suppression of the mixed leukocyte culture response and the suppression of B-cell differentiation into plasma cells by a direct effect on OKT4"T -cells , Thomas et al 1982.…”