The aim of this study is to analyze the profitability performances of the BIST manufacturing sub-sectors for the period 2019-2021 using multi-criteria decision making methods. Six profitability criteria consisting of financial ratios were determined and the profitability performances of seven sub-sectors were examined. The weights of the evaluation criteria were calculated with the CRITIC method, and the rankings were carried out using the VIKOR method. According to the results of the study the most important criteria for 2021 is return on equity, the least important criteria is the cost of sales/total revenue. While the most important criteria for 2020 is the gross profit margin, the least important one is the operating profit margin. For 2019, the most important criteria stands out as the operating profit margin, while the least important one is the net profit margin. It was determined that the Chemicals, Petroleum Rubber and Plastic Products sub-sector showed the highest profitability performance for all three years. The lowest performance was the Food, Beverage and Tobacco sub-sector in 2021, and the Non-Metallic Mineral Products in 2020 and 2019. This study differs from other studies in the literature in that it uses the CRITIC based VIKOR method. It is also one of the few studies comparing profitability performances of the manufacturing sub-sectors.