Old meets new: Combination of PLA and RDRP to obtain sophisticated macromolecular architectures

Yildirim, Ilknur; Weber, C.; Schubert, Ulrich S.

doi:10.1016/j.progpolymsci.2017.07.010

Cited by 44 publications

(26 citation statements)

References 172 publications

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“…The synthetic efforts and potential dangers [163] linked with these polymerisation techniques, however, paved the way for the exponential rise in popularity of the living radical polymerisation processes ( Figure 6) [133][134][135][136][137][138]150]. Perhaps the most popular living radical polymerisation methods are atom transfer radical polymerisation, ATRP, and reversible addition-fragmentation chain transfer, RAFT [139,140]. Numerous examples of supramolecular assemblies produced using polymeric materials obtained via these methods have been [147,148] Nitroxide-mediated polymerisation (NMP) [149] • Extremely practical processes • Easy purification • Non toxic residual alkoxyamine moieties…”

Section: A Polymers and Block-copolymersmentioning

confidence: 99%

“…• Biodegradable polyesters, polypeptides and polycarbonates • Good control of polydispersity, endchain functionality and tacticity [140,155] • Inherent pH or enzymaticallysensitiviness…”

Section: Living Ring-opening Polymerisationmentioning

confidence: 99%

“…Perhaps the most important characteristic of supramolecular assemblies for biological applications is that, ideally, they should be biodegradable, hence their structure should be suitable for the human enzymes to break them and digest them into harmless excretable components. For this reason, although they are not as new and attractive as the living radical polymerisation processes, ring-opening polymerisation (ROP) approaches of cyclic esters and anhydrides give rise to products such as biodegradable polyesters, polypeptides and polycarbonates [140,155,[182][183][184][185][186][187][188][189][190][191]. An advantage of these type of polymers is that they bear functionalities within their backbone structure which are inherently pH or enzymaticallysensitive, and hence they can be degraded in the body and release their cargo (e.g., drugs or proteins).…”

Section: Mixed Polymerisationmentioning

confidence: 99%

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Molecular bionics – engineering biomaterials at the molecular level using biological principles

et al. 2019

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Life and biological units are the result of the supramolecular arrangement of many different types of molecules, all of them combined with exquisite precision to achieve specific functions. Taking inspiration from the design principles of nature allows engineering more efficient and compatible biomaterials. Indeed, bionic (from bion-, unit of life and -ic, like) materials have gained increasing attention in the last decades due to their ability to mimic some of the characteristics of nature systems, such as dynamism, selectivity, or signalling. However, there are still many challenges when it comes to their interaction with the human body, which hinder their further clinical development. Here we review some of the recent progress in the field of molecular bionics with the final aim of providing with design rules to ensure their stability in biological media as well as to engineer novel functionalities which enable navigating the human body.

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Section: A Polymers and Block-copolymersmentioning

confidence: 99%

Section: Living Ring-opening Polymerisationmentioning

confidence: 99%

Section: Mixed Polymerisationmentioning

confidence: 99%

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Molecular bionics – engineering biomaterials at the molecular level using biological principles

et al. 2019

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“…On the other hand, the linear PLA backbone is difficult to stretch in space, it can form a crystalline hydrophobic structure easily [ 26 ]. By lactide ROP, the branching PLA could be synthesized from the centre of polyhydroxy [ 27 ]. Lactide ROP is also a common way to obtain high molecular weight PLA [ 28 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

“…In this project, we established a novel condition of high branching PLA preparation. It is generally believed that the copolymerization of glycerol with lactide is an effective way to synthesize 3-arm PLA, but this mechanism may be accompanied by the simultaneous ROP of the lactide and the dehydration of glycerol in a tank and use of metal oxide catalysts [ 27 , 29 ]. This study aims at preparing high branching PLA with hydrophilic ending group by copolymerization of lactide and glycerol.…”

Section: Introductionmentioning

confidence: 99%

Effect on electrospun fibres by synthesis of high branching polylactic acid

Shen

Zhang

et al. 2018

R. Soc. open sci.

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Polylactic electrospun porous fibres have been widely used in tissue engineering scaffolds. However, the application of linear polylactic is limited due to its poor hydrophilicity, which leads to phase separation and has been seldom used in porous fibre preparation. Instead, branching polylactic acts as a new effective method to prepare porous fibres because it can increase polylactic polar property and make it easy to be formulated in the following application. In the current study, we prepared an ultra-high molecular weight of high branching polylactic with glycerol as the initiator by controlling the ring-opening polymerization time, adding amount of catalyst and glycerol. The structure, molecular weight and thermal properties of copolymers were tested subsequently. The result showed that the surface of the high branching polylactic films is smooth, hydrophilic and porous. This branching polylactic formed electrospun porous fibres and possessed a strong adsorption of silver ion. Our study provided a simple and efficient way to synthesize branching polylactic polymer and prepare electrospun porous fibres, which may provide potential applications in the field of biomaterials for tissue engineering or antibacterial dressing compared with the application of linear polylactic and 3-arm polylactic materials.

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Multi‐Segmented Macromolecules of Linear and Grafted Topologies

Tsitsilianis

2022

Macromolecular Engineering

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In this article, synthetic strategies based on controlled/living polymerization methods that lead to well‐defined multi‐segmented (more than two building blocks) linear A/B triblock, pentablock, and multiblock copolymers, along with more complex topologies with increasing number of building blocks, differing in chemical nature (e.g. ABC, ABCD) and topology (linear and grafted architectures) are demonstrated and highlighted. The recent years, novel synthetic strategies, including “click” coupling reactions and iterative procedures, have endowed the synthetic capabilities toward developing novel macromolecular architectures with precisely controllable molecular characteristics. Attention has also been given to segmented topologies in which one or more blocks are constituted of random copolymers, targeting precise tuning of the properties of the relevant segments. This chemical diversity, integrated into a single segmented macromolecule, endows the multi‐segmented polymers with multi‐functionality and stimuli responsiveness, leading thus to polymeric materials with promising advanced applications in the context of nanotechnology and nanomedicine.

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Old meets new: Combination of PLA and RDRP to obtain sophisticated macromolecular architectures

Cited by 44 publications

References 172 publications

Molecular bionics – engineering biomaterials at the molecular level using biological principles

Molecular bionics – engineering biomaterials at the molecular level using biological principles

Effect on electrospun fibres by synthesis of high branching polylactic acid

Multi‐Segmented Macromolecules of Linear and Grafted Topologies

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