Older anti-TNF-<i>α</i>agents: why not group them for common indications in the EU?

Garattini, Livio; Ghislandi, Francesca

doi:10.1586/14737167.2016.1140576

Cited by 3 publications

(1 citation statement)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The manual mentioned at the beginning 1 clearly stated that EE is most useful and appropriate when preceded by evidence of efficacy and/or effectiveness. Nevertheless, the literature is full of EEs [9][10][11] that are likely to add only: (1) further uncertainty when based on sophisticated long-term models populated by doubtful data; and (2) poor information when based on short-term 'decision trees' derived from heterogeneous and inconclusive clinical studies. In general, on the basis of clinical studies not adequately supported by rigorous methodology, EEs can only speculate on uncertainty and overemphasise economic results of uncertain pharmacological treatments.…”

Section: Efficacy/effectivenessmentioning

confidence: 99%

Dutch guidelines for economic evaluation: ‘from good to better’ in theory but further away from pharmaceuticals in practice?

Garattini

Padula

2017

J R Soc Med

Self Cite

View full text Add to dashboard Cite

Section: Efficacy/effectivenessmentioning

confidence: 99%

Dutch guidelines for economic evaluation: ‘from good to better’ in theory but further away from pharmaceuticals in practice?

Garattini

Padula

2017

J R Soc Med

Self Cite

View full text Add to dashboard Cite

Correlation of anti-TNF-a biological therapy with periodontal conditions and osteonecrosis in autoimmune patients: A systematic review

Majdi Abunemer,

Saifuddin Shaheen,

Abudullah Alghamdi

2023

The Saudi Dental Journal

View full text Add to dashboard Cite

Structure-Based Gastro-Retentive and Controlled-Release Drug Delivery with Novel 3D Printing

Wen

Wang

et al. 2019

AAPS PharmSciTech

View full text Add to dashboard Cite

In the present contribution, the aim is to explore and establish a way in which 3D printing and gastro-retentive drug delivery systems (GRDDSs) are combined (focusing on inner structure innovation) to achieve extended and stable gastro-retention and controlled-release of drug. Three digital models diverse in construction were designed and substantialized by a pressure-assisted microsyringe (PAM) 3D printer. Preparations were characterized by means of DSC, XRD, FTIR, and SEM. In vitro buoyancy study and in vivo gamma scintigraphy method were conducted to validate gastro-retention property of these innovative preparations in vitro/in vivo respectively. Release kinetic model was established and release mechanism was discussed. Tablets manufactured under certain range of parameters (intersecting angle, full filling gap) were tight and accurate in shape. Tablets printed with specific parameters (full filling gap, 50%; nozzle extrusion speed, 0.006 mm/s; layer height, 0.4 mm; compensation value, 0.25; quantity of layers, 15; outline printing value, 2) exhibited satisfactory in vitro (10-12 h)/in vivo (8-10 h) retention ability and possessed stable 10-12 h controlled-release quality. In general, 3D printing has tremendous advantage over conventional fabrication technique in intricate drug delivery systems and will be widely employed in pharmacy.

show abstract

Older anti-TNF-αagents: why not group them for common indications in the EU?

Cited by 3 publications

References 15 publications

Dutch guidelines for economic evaluation: ‘from good to better’ in theory but further away from pharmaceuticals in practice?

Dutch guidelines for economic evaluation: ‘from good to better’ in theory but further away from pharmaceuticals in practice?

Correlation of anti-TNF-a biological therapy with periodontal conditions and osteonecrosis in autoimmune patients: A systematic review

Structure-Based Gastro-Retentive and Controlled-Release Drug Delivery with Novel 3D Printing

Contact Info

Product

Resources

About