Oleic acid induced pancreatitis in pigs

Vollmar, Brigitte; Waldner, H.; Schmand, J.; Conzen, P.; Goetz, Alwin E.; Habazettl, Helmut; Schweiberer, L.; Brendel, W.

doi:10.1016/0022-4804(91)90247-j

Cited by 13 publications

(6 citation statements)

References 17 publications

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“…In sodium taurocholate induced acute pancreatitis histological signs of pancreatic necroses, hemorrhage, edema, and inflammatory cell infiltration have been reported in previous studies [10,11,12]. Similar histological findings were seen in the current study in pancreatic parenchyma of all animals with severe acute pancreatitis.…”

Section: Discussionsupporting

confidence: 92%

Catalytic activity of phospholipase A2 in blood plasma and pancreatic tissue perfusion in early experimental acute pancreatitis

Kinnala

Grönroos

Kuttila

et al. 2002

Langenbeck’s Arch Surg

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Section: Discussionsupporting

confidence: 92%

Catalytic activity of phospholipase A2 in blood plasma and pancreatic tissue perfusion in early experimental acute pancreatitis

Kinnala

Grönroos

Kuttila

et al. 2002

Langenbeck’s Arch Surg

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“…Third, it is possible that the pressor response observed in our study was a manifestation of a toxic rather than a physiologic effect. Fatty acids have detergent properties, and infusion of high doses has been used to induce experimental lung (25) and pancreatic (26) damage. The increase in catecholamines would be consistent with a stress response.…”

Section: Discussionmentioning

confidence: 99%

Elevated plasma fatty acid concentrations stimulate the cardiac autonomic nervous system in healthy subjects

Paolisso

Manzella

Rizzo

et al. 2000

The American Journal of Clinical Nutrition

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Background: Fatty acids have been shown to stimulate the sympathetic nervous system in rats. Power spectral analysis of heart rate variability (HRV) is a safe and useful tool with which to evaluate cardiac autonomic nervous system (ANS) activity. Whether changes in plasma fatty acid concentrations affect the sympathetic nervous system or HRV in humans is unknown. Objective: We investigated the possible changes in HRV after a significant increase in plasma fatty acid concentration. Design: Subjects were randomly assigned to receive an infusion of lipid emulsion (10% triacylglycerol emulsion for 180 min) + heparin (a bolus of 200 U followed by 0.2 U · min Ϫ1 · kg body wt Ϫ1 ; n = 20) or 0.9% NaCl (for 180 min; n = 10). Results: Lipid emulsion + heparin infusion was associated with a rise in plasma epinephrine and norepinephrine concentrations. The rise in plasma fatty acid concentration was associated with a significant decline in the RR interval (P < 0.03) and in total power (P < 0.03). Analysis of the different components of HRV showed that lipid emulsion + heparin infusion stimulated lowfrequency (LF) components (P < 0.03 at the second hour and P < 0.01 at the third hour) and inhibited high-frequency (HF) components (P < 0.03 at the second and third hours). Consequently, the LF-HF ratio was significantly stimulated (P < 0.03 at the second hour and P < 0.01 at the third hour). Such results persisted, although attenuated, when the study was repeated in association with a propranolol infusion (n = 8). Conclusion: Elevated plasma fatty acid concentrations may stimulate cardiac autonomic nervous system activity.Am J Clin Nutr 2000;72:723-30.

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“…Ever since the intravenous infusion of ascitic fluid from animals with pancreatitis was noted to cause hypotension in healthy recipients [115], many investigators have described an increase in vasoactive substances such as kinins in AP [115, 116, 117, 118]. Acute inflammation in the pancreas is mediated in part by activation of bradykinin through the action of biologically active tissue peptides such as the kallikreins [60, 119].…”

Section: Ischemia/reperfusion Injury Of the Pancreasmentioning

confidence: 99%

Ischemia/Reperfusion-Induced Pancreatitis

Sakorafas

Tsiotos

Sarr³

2000

Dig Surg

101

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Background/Aim: The pancreas is an organ highly susceptible to ischemic damage. This discussion reviews the role of ischemia as an etiologic factor in acute pancreatitis. Methods: Literature review. Results: The susceptibility of the pancreas to ischemia/reperfusion injury has been demonstrated in experimental studies and in clinical settings such as cardiopulmonary bypass, hemorrhagic shock, and transplantation of the pancreas. Oxygen free radicals, activation of polymorphonuclear leukocytes, failure of microvascular perfusion, cellular acidosis, and disturbance of intracellular homeostasis appear to be important factors/mechanisms in the pathogenesis of ischemia/reperfusion-induced acute pancreatitis. In clinical practice, the diagnosis of ischemic pancreatitis is difficult and often delayed, especially during the postoperative period after cardiac or major vascular surgery. Conclusions: Ischemia appears to be one important factor in acute pancreatitis. The management of ischemic pancreatitis is similar to that of acute pancreatitis of any etiology.

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Oleic acid induced pancreatitis in pigs

Cited by 13 publications

References 17 publications

Catalytic activity of phospholipase A2 in blood plasma and pancreatic tissue perfusion in early experimental acute pancreatitis

Catalytic activity of phospholipase A2 in blood plasma and pancreatic tissue perfusion in early experimental acute pancreatitis

Elevated plasma fatty acid concentrations stimulate the cardiac autonomic nervous system in healthy subjects

Ischemia/Reperfusion-Induced Pancreatitis

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