Oleic acid induces apoptosis and autophagy in the treatment of Tongue Squamous cell carcinomas

Jiang, Lin; Wang, Wei; He, Qiuming; Wu, Yuan; Lu, Zhiyuan; Sun, Jingjing; Z, Liu; Shao, Yisen; Wang, Anxun

doi:10.1038/s41598-017-11842-5

Cited by 102 publications

(80 citation statements)

References 44 publications

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“…Conversely, Miller et al () suggested that the growth‐inhibitory effects of milk fat on SW480 and MCF‐7 cells could be in part related to the high levels of OLA present in milk fat. Although some studies found that OLA at low concentrations (<50 μM) could promote the proliferation of cancer cells (Falconer et al, ; Nano et al, ), higher concentrations of OLA (>100 μM) have been shown to have potent anticancer effects by inducing cell cycle G0/G1 arrest, apoptosis, and autophagy in cancer cells (Fernanda Cury‐Boaventura et al, ; Jiang et al, ). In the present study, the effective dose of low‐BHI SCF (i.e.…”

Section: Discussionmentioning

confidence: 99%

The Growth‐Inhibiting Effects of Beef Fatty Acids on MCF‐7 Cells Are Influenced Mostly by the Depot Location and Inconsistently by the Biohydrogenation Intermediate Content

Vahmani

Rolland

Gzyl

et al. 2018

Lipids

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Biohydrogenation intermediates (BHI) including conjugated linoleic acid (CLA) isomers are formed during ruminal biohydrogenation of polyunsaturated fatty acids (PUFA) in ruminants. Although many studies have examined the anticarcinogenic effects of CLA, few studies have reported the anticarcinogenic properties of BHI in their natural form found in dairy and beef fats. The present study compared the growth‐inhibitory effects of fatty acids from beef perirenal fat (PRF) or subcutaneous fat (SCF) with low or high levels of BHI in MCF‐7 human breast cancer cells. Cells were exposed for 72 h to media containing increasing doses (50 to 400 μM) of different beef fat treatments. Fatty‐acid analysis showed that BHI were readily incorporated into cell phospholipids (PL) in a treatment‐dependent manner, but higher BHI in PL did not consistently inhibit growth. Culturing with low‐BHI PRF or high‐BHI PRF did not lead to growth inhibition, but low‐BHI SCF inhibited growth, and inhibition was further increased by high‐BHI SCF. Other classes of fatty acids may, therefore, be interacting with BHI resulting in differential effects on growth inhibition in human breast cancer cells.

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Section: Discussionmentioning

confidence: 99%

The Growth‐Inhibiting Effects of Beef Fatty Acids on MCF‐7 Cells Are Influenced Mostly by the Depot Location and Inconsistently by the Biohydrogenation Intermediate Content

Vahmani

Rolland

Gzyl

et al. 2018

Lipids

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“…All the evidence indicated that OA could elicit an induction of a process related to autophagy by the Akt/mTOR pathway. Moreover, a growth rate of inhibition of 58% (after 40 days of treatment with 4 mg of 48 ) was demonstrated in an in vivo assay on xenograft nude mice expressing OSCC cells . In an interesting paper, the synergistic effect of Gambogic acid ( 49 ) with RT was investigated.…”

Section: Autophagy Modulators In Oscc and Esccmentioning

confidence: 99%

Autophagy modulators for the treatment of oral and esophageal squamous cell carcinomas

Khan

Relitti

Brindisi

et al. 2019

Medicinal Research Reviews

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Oral squamous cell carcinomas (OSCC) and esophageal squamous cell carcinomas (ESCC) exhibit a survival rate of less than 60% and 40%, respectively. Late-stage diagnosis and lack of effective treatment strategies make both OSCC and ESCC a significant health burden. Autophagy, a lysosome-dependent catabolic process, involves the degradation of intracellular components to maintain cell homeostasis. Targeting autophagy has been highlighted as a feasible therapeutic strategy with clinical utility in cancer treatment, although its associated regulatory mechanisms remain elusive. The detection of relevant biomarkers in biological fluids has been anticipated to facilitate early diagnosis and/or prognosis for these tumors. In this context, recent studies have indicated the presence of specific proteins and small RNAs, detectable in circulating plasma and serum, as biomarkers. Interestingly, the interplay between biomarkers (eg, exosomal microRNAs) and autophagic processes could be exploited in the quest for targeted and more effective therapies for OSCC and ESCC. In this review, we give an overview of the available biomarkers and innovative targeted therapeutic strategies, including the application of autophagy modulators in OSCC and ESCC.Additionally, we provide a viewpoint on the state of the art Tuhina Khan and Nicola Relitti contributed equally to this work. and on future therapeutic perspectives combining the early detection of relevant biomarkers with drug discovery for the treatment of OSCC and ESCC. K E Y W O R D S autophagy, autophagy modulators, biomarkers, esophageal squamous cell carcinoma, exosomes, oral squamous cell carcinoma, targeted therapy 1 | INTRODUCTION Oral squamous cell carcinoma (OSCC) is the predominant malignant neoplasm of the oral cavity followed by verrucous carcinoma, undifferentiated carcinoma, and small salivary adenocarcinoma. 1 Esophageal squamous cell carcinoma (ESCC) is the first histological type and accounts for 80% of cases of esophageal cancer. 2 OSCC and ESCC are indicated as one of the most common cancers by the International Union Against Cancer with an annual incidence of 275 000 and 456 000 cases worldwide, respectively. 3,4 The primary etiology in both OSCC and ESCC is attributed to the environmental factors (tobacco abuse, alcohol consumption), genetic factors (eg, mutations in enzymes), viral factors (human papilloma virus [HPV] infection), and/or the coexistence of these factors. Alcohol intake and tobacco use are responsible for at least 75% of these carcinomas. The underlying initiation and progression mechanisms of OSCC and ESCC are generally characterized by the accumulation of serial epigenetic and genetic alterations, which eventually lead to uncontrolled proliferation of the mutated cells, followed by vigorous cell division. 5,7 Early-stage OSCC detection displays an 80% survival rate at 5 years, while detection at advanced stage leads to survival rates ranging from 20% to 40%. 6 In ESCC, the 5-year survival rate for early-stage detection may reach 85%, whereas a dr...

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“…Up-regulation of macrolipophagy was first detected in hepatocytes exposed to high levels of oleic acid (22). Subsequent studies showed that lipid overload can increase autophagy in cells including neurons, beta cells, myocytes and epithelial cells (66–70). Conversely, blocking autophagy in cultured myocytes leads to elevated TG levels and cell death as a result of lipid overload (71).…”

Section: Functions Of Lipophagymentioning

confidence: 99%

Lipid droplet autophagy during energy mobilization lipid homeostasis and protein quality control

2018

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Lipid droplets (LDs) have well-established functions as sites for lipid storage and energy mobilization to meet the metabolic demands of cells. However, recent studies have expanded the roles of LDs to protein quality control. Lipophagy, or LD degradation by autophagy, plays a vital role not only in the mobilization of free fatty acids (FFAs) and lipid homeostasis at LDs, but also in the adaptation of cells to certain forms of stress including lipid imbalance. Recent studies have provided new mechanistic insights about the diverse types of lipophagy, in particular microlipophagy. This review summarizes key findings about the mechanisms and functions of lipophagy and highlights a novel function of LD microlipophagy as a mechanism to maintain endoplasmic reticulum (ER) proteostasis under conditions of lipid imbalance.

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Oleic acid induces apoptosis and autophagy in the treatment of Tongue Squamous cell carcinomas

Cited by 102 publications

References 44 publications

The Growth‐Inhibiting Effects of Beef Fatty Acids on MCF‐7 Cells Are Influenced Mostly by the Depot Location and Inconsistently by the Biohydrogenation Intermediate Content

The Growth‐Inhibiting Effects of Beef Fatty Acids on MCF‐7 Cells Are Influenced Mostly by the Depot Location and Inconsistently by the Biohydrogenation Intermediate Content

Autophagy modulators for the treatment of oral and esophageal squamous cell carcinomas

Lipid droplet autophagy during energy mobilization lipid homeostasis and protein quality control

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