Oleic acid is the main fatty acid related with carotenogenesis in Dunaliella salina

Mendoza, H.; Martel, A. Conde; Río, M. Jiménez del; Reina, Guillermo García

doi:10.1007/978-94-011-4449-0_65

Cited by 38 publications

(47 citation statements)

References 16 publications

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“…These lipid globules can sequester the apolar carotenoids and may thereby serve as a metabolic sink, transporting b-carotene away from its biosynthetic machinery and consequently avoiding end-product inhibition of the carotenoid biosynthetic enzymes (Rabbani et al, 1998). The positive correlation between oleic acid (C18:1) and bcarotene levels in D. salina cells grown at various light intensities (Mendoza et al, 1999) is in support of this metabolic sink theory, as are the concomitant b-carotene and total fatty acid increases observed for high-light-treated (Rabbani et al, 1998) and nitrogen deprived, high-lighttreated D. salina cells (Mendoza et al, 1999).…”

Section: Introductionmentioning

confidence: 97%

Carotenoid and fatty acid metabolism in light‐stressed Dunaliella salina

Lamers

Laak

Kaasenbrood

et al. 2010

Biotech & Bioengineering

238

127

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beta-Carotene is overproduced in the alga Dunaliella salina in response to high light intensities. We have studied the effects of a sudden light increase on carotenoid and fatty acid metabolism using a flat panel photobioreactor that was run in turbidostat mode to ensure a constant light regime throughout the experiments. Upon the shift to an increased light intensity, beta-carotene production commenced immediately. The first 4 h after induction were marked by constant intracellular levels of beta-carotene (2.2 g LCV(-1)), which resulted from identical increases in the production rates of cell volume and beta-carotene. Following this initial phase, beta-carotene productivity continued to increase while the cell volume productivity dropped. As a result, the intracellular beta-carotene concentration increased reaching a maximum of 17 g LCV(-1) after 2 days of light stress. Approximately 1 day before that, the maximum beta-carotene productivity of 30 pg cell(-1) day(-1) (equivalent to 37 mg LRV(-1) day(-1)) was obtained, which was about one order of magnitude larger than the average productivity reported for a commercial beta-carotene production facility, indicating a vast potential for improvement. Furthermore, by studying the light-induced changes in both beta-carotene and fatty acid metabolism, it appeared that carotenoid overproduction was associated with oil globule formation and a decrease in the degree of fatty acid unsaturation. Our results indicate that cellular beta-carotene accumulation in D. salina correlates with accumulation of specific fatty acid species (C16:0 and C18:1) rather than with total fatty acid content.

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Section: Introductionmentioning

confidence: 97%

Carotenoid and fatty acid metabolism in light‐stressed Dunaliella salina

Lamers

Laak

Kaasenbrood

et al. 2010

Biotech & Bioengineering

238

127

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“…These secondary metabolites are produced as the organism response to different stress condition, for example glycerol is produced after salt-stress induction [12,20,24], neutral lipids and antioxidants (e.g. β-carotene) in response to macronutrient starvation [9,21,22,41] and high light intensity [2,13,18]; production of carotenoids, especially α-carotene and 9-cis β-carotene [10,17,25] in low temperature, and can intensify in the presence of multiple stresses [1,2].…”

Section: Introductionmentioning

confidence: 99%

Accumulation of lipid in <i>Dunaliella salina </i>under Nutrient Starvation Condition

Mai¹,

Nguyen²,

Vo³

et al. 2017

AJFN

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The effect of nutrient starvation on lipid accumulation of Dunaliella salina A9 was studied. In nutrient starvation, cell colour changed from green to yellow (or orange) and cell growth reached stationary phase after 9 days of the culture. The study showed that under nutrient stress, decreased in cell growth is accompanied by carotenoid biosynthesis and lipid content of Dunaliella salina. The results of this study can be used to increase carotenoid and lipid production in microalgae for functional food and biofuel in the future.

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“…Particularly, great potential of valuable polyunsaturated fatty acids (PUFAs) produced by photoautotrophic microalgae for large-scale microalgal industries have been found (Thompson 1996;Mendoza et al 1999;Sukenik 1999). Among PUFAs, arachidonic acid (ARA) and eicosapentaenoic acid (EPA) are two of the most valuable extracts of microalgae.…”

Section: Introductionmentioning

confidence: 99%

Enhancing total fatty acids and arachidonic acid production by the red microalgae Porphyridium purpureum

Jiao

Chang

et al. 2016

Bioresour. Bioprocess.

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Objectives: This study investigated the effect of aeration rate and light intensity on biomass production and total fatty acids (TFA) accumulation by Porphyridium purpureum. The red microalgae is also known to accumulate considerable amount of arachidonic acid (ARA). Results:In artificial seawater medium, the highest yield of TFA (473.44 mg/L) was obtained with the aeration rate of 3 L/min and light intensity of 165 µmol/m 2 s, whilst the highest yield of ARA (115.47 mg/L) was achieved with the aeration rate of 3 L/min and light intensity of 110 µmol/m 2 s. It was found that higher aeration rate led to more biomass and TFA/ARA production. However, higher light intensity could contribute to biomass accumulation, but it was adverse for TFA and ARA biosynthesis. Conclusion:By optimizing two operating factors (i.e., light intensity and aeration rate), TFA and ARA production by P. purpureum was significantly improved. This research provides a potential alternative means for producing ARA.

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Oleic acid is the main fatty acid related with carotenogenesis in Dunaliella salina

Cited by 38 publications

References 16 publications

Carotenoid and fatty acid metabolism in light‐stressed Dunaliella salina

Carotenoid and fatty acid metabolism in light‐stressed Dunaliella salina

Accumulation of lipid in <i>Dunaliella salina </i>under Nutrient Starvation Condition

Enhancing total fatty acids and arachidonic acid production by the red microalgae Porphyridium purpureum

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