Oleic acid protects saturated fatty acid mediated lipotoxicity in hepatocytes and rat of non-alcoholic steatohepatitis

Chen, Xuanming; Li, Linzhao; Liu, Xiaohong; Luo, Ruixi; Liao, Guangneng; Li, Lan; Liu, Jingping; Cheng, Jingqiu; Liu, Yanrong; Chen, Younan

doi:10.1016/j.lfs.2018.04.022

Cited by 125 publications

(99 citation statements)

References 37 publications

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“…that diets rich in MUFA have protective effects on cardiovascular risk, non-alcoholic fatty liver disease and diabetes (Chen et al, 2018). These results are in agreement with a study performed by Tang et al (2015), who indicated that linoleic and oleic are the major acids in black, red and white quinoa; yet at higher concentrations (47-49% and 25-29%, respectively).…”

Section: Chemical Compositionsupporting

confidence: 92%

Chemical and nutritional characterization of Chenopodium quinoa Willd (quinoa) grains: A good alternative to nutritious food

et al. 2019

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With the purpose of valuing the species Chenopodium quinoa Willd (quinoa), as well as encouraging the consumption of its grains, this study aimed at providing a detailed evaluation of the nutritional value and chemical composition of several quinoa grains of different colour varieties (black, red and white) from different origins. The results demonstrated an excellent composition, namely in the presence of many compounds of interest, such as organic acids, tocopherols and unsaturated fatty acids, as well as a very favourable nutritional profile, with carbohydrates and proteins being the prominent macronutrients. Regarding the different varieties, statistical analysis showed that there were no significant differences in studied parameters, with the exception of proteins, carbohydrates, oxalic acid, γ-tocopherol and total tocopherols content. Thus, this pseudocereal takes a position of nutritional excellence, compared to others cereals more commonly consumed, thereby representing a promising ingredient for many uses in the food industry. Hernández-Ledesma, 2017). Some scientific studies have been developed to characterize Chenopodium quinoa Willd; however, this study intends to make a

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Section: Chemical Compositionsupporting

confidence: 92%

Chemical and nutritional characterization of Chenopodium quinoa Willd (quinoa) grains: A good alternative to nutritious food

et al. 2019

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“…Compared with other NASH models, the MCD model can cause more severe inflammation, oxidative stress and apoptosis. Fat accumulation in the form of triglycerides in hepatocytes is the major feature of hepatic steatosis 23 . FFA-overloaded murine primary hepatocytes exhibited comparable lipid contents, which was similar to lipid accumulation in hepatocytes obtained from human steatotic liver.…”

Section: Discussionmentioning

confidence: 99%

CCN1 promotes hepatic steatosis and inflammation in non-alcoholic steatohepatitis

Sun

Xue

et al. 2020

Sci Rep

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Non-alcoholic fatty liver disease (NAFLD) is characterized by increased uptake and accumulation of lipids in hepatocytes. Simple steatosis may progress to non-alcoholic steatohepatitis (NASH) with inflammation, hepatocellular injury and fibrosis. CCN1 is an important matrix protein that regulates cell death and promotes immune cell adhesion and may potentially control this process.The role of CCN1 in NASH remains unclear. We investigated the role of CCN1 in the pathogenesis of steatohepatitis. CCN1 upregulation was found to be closely related with steatosis in patients with NASH, obese mice and a FFA-treated hepatocyte model. Controlling the expression of CCN1 in murine NASH models demonstrated that CCN1 increased the severity of steatosis and inflammation. From the sequence results, we found that fatty acid metabolism genes were primarily involved in the MCD mice overexpressing CCN1 compared to the control. Then, the expression of fatty acid metabolism genes was determined using a custom-designed pathway-focused qPCR-based gene expression array. Expression analysis showed that CCN1 overexpression significantly upregulated the expression of fatty acid metabolism-associated genes. In vitro analysis revealed that CCN1 increased the intracellular TG content, the pro-inflammatory cytokines and the expression level of apoptosis-associated proteins in a steatosis model using murine primary hepatocytes. We identified CCN1 as an important positive regulator in NASH.

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“…Besides the obvious difference between the cell damage caused by saturated and unsaturated FAs, the potentially protective effect of oleate against palmitate toxicity has also drawn growing attention in the past few years. Simultaneously added oleate alleviated palmitate induced toxicity in various cells, including hepatocytes and hepatoma cells [17], human mesenchymal stromal cells and osteoblasts [18], and also decreased non-alcoholic steatohepatitis (NASH) injury in rats with high fat diets [17]. Most importantly, it has been shown that co-administration of oleate can prevent palmitate-induced activation of the unfolded protein response (UPR) in β-cells [19].…”

Section: Introductionmentioning

confidence: 99%

Effect of cis- and trans-Monounsaturated Fatty Acids on Palmitate Toxicity and on Palmitate-induced Accumulation of Ceramides and Diglycerides

Sarnyai

Somogyi

Gór-Nagy

et al. 2020

IJMS

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Dietary trans fatty acids (TFAs) have been implicated in serious health risks, yet little is known about their cellular effects and metabolism. We aim to undertake an in vitro comparison of two representative TFAs (elaidate and vaccenate) to the best-characterized endogenous cis-unsaturated FA (oleate). The present study addresses the possible protective action of TFAs on palmitate-treated RINm5F insulinoma cells with special regards to apoptosis, endoplasmic reticulum stress and the underlying ceramide and diglyceride (DG) accumulation. Both TFAs significantly improved cell viability and reduced apoptosis in palmitate-treated cells. They mildly attenuated palmitate-induced XBP-1 mRNA cleavage and phosphorylation of eukaryotic initiation factor 2α (eIF2α) and stress-activated protein kinase (SAPK)/c-Jun N-terminal kinase (JNK), but they were markedly less potent than oleate. Accordingly, all the three unsaturated FAs markedly reduced cellular palmitate incorporation and prevented harmful ceramide and DG accumulation. However, more elaidate or vaccenate than oleate was inserted into ceramides and DGs. Our results revealed a protective effect of TFAs in short-term palmitate toxicity, yet they also provide important in vitro evidence and even a potential mechanism for unfavorable long-term health effects of TFAs compared to oleate.

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Oleic acid protects saturated fatty acid mediated lipotoxicity in hepatocytes and rat of non-alcoholic steatohepatitis

Cited by 125 publications

References 37 publications

Chemical and nutritional characterization of Chenopodium quinoa Willd (quinoa) grains: A good alternative to nutritious food

Chemical and nutritional characterization of Chenopodium quinoa Willd (quinoa) grains: A good alternative to nutritious food

CCN1 promotes hepatic steatosis and inflammation in non-alcoholic steatohepatitis

Effect of cis- and trans-Monounsaturated Fatty Acids on Palmitate Toxicity and on Palmitate-induced Accumulation of Ceramides and Diglycerides

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