Oleoylsalicylate Derivatives: Synthesis and Antifungal Activity

Bassoli, Angela; Borgonovo, Gigliola; Caimi, S.; Farina, G.; Moretti, Massimo

doi:10.2174/1874848100801010014

Cited by 3 publications

(1 citation statement)

References 13 publications

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“…Numerous studies have found that the concentrations of tested fungicides are crucial for activity. Previously, antifungal activites of oleoylsalicylate derivatives [50], pyrimethanil grafted chitosan derivatives [51], thymol derivatives [52], ergosterol peroxide [53], benzothiazole-appended bis-triazole-based derivatives [54], and piperazine containing chalcones [55] were tested against R. solani and the results were found to be highly dependent on concentrations.…”

Section: Antifungal Activity Of Synthesized Flavonesmentioning

confidence: 99%

Synthesis and Anti-Plant Pathogenic Fungal Activity of Flavokawain-Derived Flavones and Related Flavones Against Rhizoctonia solani

Onnom,

Chotpatiwetchkul,

Meesin

et al. 2023

Curr. Appl. Sci. Technol.

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Flavones are organic compounds in the flavonoid family that have a diverse range of biological functions. In this research, many flavones with various substituents were designed and synthesized from flavokawains A, B, and C, and their chalcone derivatives via an iodine-catalyzed oxidative cyclization process. All synthetic flavones were investigated for antifungal activities against Rhizoctonia solani, a plant pathogenic fungus. At 400 µg, most of the substances did not inhibit the tested species and R. solani growth was inhibited by only o-bromoflavone (40) by 74.88±0.91%. This indicated that the detrimental effect of flavones depends on the type and position of substituent, with the ortho bromo group showing the most promise. The molecular docking study on the succinate dehydrogenase (SDH) enzyme revealed that the bromophenyl moiety (ring B) is a key molecular substructure of the flavone fungicide. The findings of this study will be used to develop novel plant pathogenic fungicides.

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Section: Antifungal Activity Of Synthesized Flavonesmentioning

confidence: 99%

Synthesis and Anti-Plant Pathogenic Fungal Activity of Flavokawain-Derived Flavones and Related Flavones Against Rhizoctonia solani

Onnom,

Chotpatiwetchkul,

Meesin

et al. 2023

Curr. Appl. Sci. Technol.

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4-Bromo-2-hydroxybenzoic acid

Suchetan

Suneetha²,

Naveen

et al. 2016

IUCr Data

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In the title compound, C7H5BrO3, the dihedral angle between the aromatic ring and the carboxylic acid group is 4.8 (4)°, and an intramolecular O—H...O hydrogen bond closes anS(6) ring. In the crystal, carboxylic acid inversion dimers linked by pairs of O—H...O hydrogen bonds generateR22(8) loops. Short Br...Br contacts [3.4442 (5) Å] between the molecules of the adjacent dimers leads to a one-dimensional architecture.

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