Oleuropein an Olive Oil Compound in Acute and Chronic Inflammation Models: Facts and Perspectives

Synergistic analgesic, anti‐pyretic and anti‐inflammatory effects of extra virgin olive oil and ibuprofen in different experimental models of albino mice

“…These findings were in accordance with others who found that oleuropein was able to reduce significantly the serum level of PGE2. Similarly, it was found that olive oil reduced expression of COX2 at both the mRNA and protein level .…”

“…These findings coincided with other results studying the effect of the so‐called ‘unsaponifiable fraction’ of virgin olive oil (erythrodiol, β‐sitosterol and squalene), and the phenolic compounds from the ‘polar fraction’ (oleuropein, tyrosol, hydroxytyrosol and caffeic acid) . That study found that most of these compounds significantly reduced the neutrophil influx in the inflamed tissues, which was also confirmed elsewhere . It has been demonstrated that olive oil was able to control inflammation markedly in carrageenan‐induced inflammation in rats and its effect was augmented by indomethacin…”

“…Other studies also found that olive oil phenols decreased the levels of other cytokines such as the levels of C‐reactive protein, interleukin‐6, ‐7 and ‐18, the levels of thromboxane B2, thromboxane B4 and leukotriene B4 metalloproteinase‐9 and the levels of interleukin‐1β and tumor necrosis factor‐α …”

Olive oil

“…There are hundreds of studies aiming at evaluating health effects of extra virgin olive oil due to polar phenols and assessing the nutraceutical properties of different kinds of olive oil and individual phenols. The latter is pharmaceutically a very interesting molecule and has been extensively studied (Omar, 2010;Britti et al, 2012). The phenols most studied are hydroxytyrosol, oleuropein, and p-HPEA-EDA, also known as oleocanthal (both enantiomers), which possess similar anti-inflammatory properties to ibuprofen and may be an important factor within the Mediterranean diet in reducing the risk of a number of diseases related to inflammation (Pérez et al, 2014;Cicerale et al, 2011).…”

Approaches in Hydroxytyrosol Supplementation on Epithelial—Mesenchymal Transition in TGFβ1-Induced Human Respiratory Epithelial Cells

“…Interestingly, olive leaves have been used to treat asthma traditionally [ 20 ]. Other than that, OE and its active compounds can also act as antioxidant agents on lung epithelial cells and reduce inflammation in lung tissue [ 21 , 22 ].…”