Olfactory Bulb Recovery after Early Sensory Deprivation

Cummings, Diana M.; Henning, H. E.; Brunjes, Peter C.

doi:10.1523/jneurosci.17-19-07433.1997

Cited by 122 publications

(104 citation statements)

References 38 publications

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“…To regulate olfactory input reversibly, naris occlusion plugs (Cummings et al, 1997) were used. These plugs were made of polyethylene tubing (SP35, Natume), silk thread (4 -0, Akiyama), and a piece of Japanese female hair to be used as a pull string.…”

Section: Methodsmentioning

confidence: 99%

Sensory Input Regulates Spatial and Subtype-Specific Patterns of Neuronal Turnover in the Adult Olfactory Bulb

Sawada¹,

Kaneko²,

Inada³

et al. 2011

J. Neurosci.

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Throughout life, new neurons are added and old ones eliminated in the adult mouse olfactory bulb. Previous studies suggested that olfactory experience controls the process by which new neurons are integrated into mature circuits. Here we report novel olfactoryexperience-dependent mechanisms of neuronal turnover. Using two-photon laser-scanning microscopy and sensory manipulations in adult live mice, we found that the neuronal turnover was dynamically controlled by olfactory input in a neuronal subtype-specific manner. Olfactory input enhanced this turnover, which was characterized by the reiterated use of the same positions in the glomeruli by new neurons. Our results suggest that olfactory-experience-dependent modification of neuronal turnover confers structural plasticity and stability on the olfactory bulb.

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Section: Methodsmentioning

confidence: 99%

Sensory Input Regulates Spatial and Subtype-Specific Patterns of Neuronal Turnover in the Adult Olfactory Bulb

Sawada¹,

Kaneko²,

Inada³

et al. 2011

J. Neurosci.

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“…Olfactory input is a critical factor for the survival of new neurons in the OB. Several studies using anosmic mice, 80 olfactory deprivation, [81][82][83] and various odorants 84,85 revealed that olfactory input promotes the survival of newly arrived neurons in the OB. A recent study revealed that new granule cells are eliminated during the postprandial period, and this elimination is enhanced by olfactory deprivation.…”

Section: Neuronal Maturation and Turnover In The Olfactory Bulbmentioning

confidence: 99%

Mechanisms of Neurogenesis in the Normal and Injured Adult Brain

Sawada

Sawamoto

2013

Keio J. Med.

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Even in the adult brain, new neurons are continuously generated from endogenous neural stem cells that reside in two restricted regions: the subventricular zone (SVZ) of the lateral ventricle and the dentate gyrus of the hippocampus. These new neurons are integrated into the mature neuronal circuitry and become involved in various functions, thereby contributing to structural and functional plasticity in the adult brain. In this review, we summarize our recent findings on the regulatory mechanisms of SVZ neurogenesis under physiological and pathological conditions in various animal models. Some of these findings were presented in the Kitazato Prize Lecture at Keio University School of Medicine in

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“…The nose plug was fabricated as described in Cummings et al (1997). The plugs were constructed out of polyethylene tubing (PE 50; Becton Dickinson, Parsippany, NJ), silk surgical suture thread (3-0), and human hair.…”

Section: Animalsmentioning

confidence: 99%

Odorant Deprivation Reversibly Modulates Transsynaptic Changes in the NR2B-Mediated CREB Pathway in Mouse Piriform Cortex

Kim¹,

Puché²,

Margolis³

2006

J. Neurosci.

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The olfactory system is an outstanding model for understanding activity-dependent neuronal plasticity in mammals. Olfactory sensory neurons (OSNs) in the periphery project onto mitral/tufted cells in the olfactory bulb (OB) and these mitral/tufted cells in turn project to piriform cortex (PC). Numerous studies have examined changes in OB after a permanent OSN ablation, but little is known about "trans-transsynaptic" changes taking place in the PC. Permanent zinc sulfate lesion of the olfactory epithelium resulted in a selective loss of the NMDA receptor NR2B protein and mRNA expression in pyramidal cells in layer IIb of PC after 2-7 d. Regulatory elements affected by NR2B signaling, namely the phosphorylation of CREB, were also downregulated only in layer IIb neurons. These changes could be caused by OSN axon loss in the zinc sulfate lesion, or to a reduced activity. To test this hypothesis, we performed both permanent and reversible naris occlusion, which blocks odorant access to the nasal cavities and OSN activity. The expression of NR2B and phospho-CREB were downregulated 5 d after occlusion and this reduction was fully restored 10 d after reopening of the naris. Subsequently, we identified the subset of pyramidal cells in layer IIb that are especially sensitive to the loss of odor-evoked activity using double retrograde tracers. In summary, the present study provides an initial characterization of the molecular mechanisms associated with odor stimulation on second order neuronal plasticity and phenotype in the olfactory system.

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Olfactory Bulb Recovery after Early Sensory Deprivation

Cited by 122 publications

References 38 publications

Sensory Input Regulates Spatial and Subtype-Specific Patterns of Neuronal Turnover in the Adult Olfactory Bulb

Sensory Input Regulates Spatial and Subtype-Specific Patterns of Neuronal Turnover in the Adult Olfactory Bulb

Mechanisms of Neurogenesis in the Normal and Injured Adult Brain

Odorant Deprivation Reversibly Modulates Transsynaptic Changes in the NR2B-Mediated CREB Pathway in Mouse Piriform Cortex

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