Olfactory bulb volume and olfactory function after radiotherapy in patients with nasopharyngeal cancer

Veyseller, Bayram; Özüçer, Berke; Degirmenci, Nazan; Gürbüz, Defne; Tambaş, Makbule; Altun, Musa; Aksoy, Fadullah; Özturan, Orhan

doi:10.1016/j.anl.2014.02.004

Cited by 18 publications

(12 citation statements)

References 18 publications

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“…In the present study, statistically significant changes in the quantitative determination of odour occurred in the fourth week, respectively at the radiation dose of 40Gy (Table 2). Similarly, other studies have shown a decrease in the ability to quantitatively assess odour at the end of the radiation therapy [13][14][15] .…”

Section: Resultsmentioning

confidence: 84%

Evaluation of smell disorders after radiotherapy in patients with laryngeal neoplasm

Műhlfay

Neagos

et al. 2020

Romanian Journal of Rhinology

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BACKGROUND. Smell disorders may be classified in quantitative and qualitative. The literature shows that the main causes of odour disorders, both qualitative and quantitative, are due to aging, viral infections and tumors of the upper respiratory tract, craniocerebral trauma, neurodegenerative diseases of the nervous system, drug use or exposure to various toxic substances. Total laryngectomy and oncologic treatment causes smell disorders.OBJECTIVE. The aim of this study is to evaluate the aspects related to the patient’s smell disorders after total laryngectomy, during the oncological treatment represented by radiotherapy.MATERIAL AND METHODS. A prospective observational study was performed on a group of 52 patients, over a period of one year (2016-2017), who benefited from total laryngectomy and who underwent oncological treatment, represented by radiotherapy. Patients were evaluated before starting radiotherapy and during radiotherapy sessions. All patients underwent quantitative and qualitative smell assessment.RESULTS. At the end of week 7 of radiotherapy, none of the patients was considered normosmic, 10 patients were considered to be suffering from hyposmia and 42 from anosmia. Statistically significant changes in the quantitative determination of odour occurred in the fourth week, respectively at the radiation dose of 40Gy. Qualitative odour assessment in this study showed a statistically significant decrease starting with the fifth week of radiotherapy, respectively with a radiation dose of 50Gy.CONCLUSION. Radiation therapy has a major impact on the quality of life of patients with laryngeal cancer, which has the lowest scores at the beginning and end of the treatment.

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Section: Resultsmentioning

confidence: 84%

Evaluation of smell disorders after radiotherapy in patients with laryngeal neoplasm

Műhlfay

Neagos

et al. 2020

Romanian Journal of Rhinology

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“…55 Studies have used different methodologies but associations with age, sex, 430,441,447,453 and mood disorders 429,434,435,440,441 have been observed. Association with disease activity, 427,435,437,441,442,444,445,[447][448][449][450]452,453,[457][458][459][460]462,467,468,470,471,473,474 neurological manifestations, 435,[437][438][439][440][441][442][443]445,447,450,452,453,[457][458]…”

Section: G Related To Underlying Systemic Disease 1 Autoimmunementioning

confidence: 99%

International consensus statement on allergy and rhinology: Olfaction

Patel

Holbrook

Turner

et al. 2022

Int Forum Allergy Rhinol

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Background:The literature regarding clinical olfaction, olfactory loss, and olfactory dysfunction has expanded rapidly over the past two decades, with an exponential rise in the past year. There is substantial variability in the quality of this literature and a need to consolidate and critically review the evidence. It is with that aim that we have gathered experts from around the world to produce this International Consensus on Allergy and Rhinology: Olfaction (ICAR:O). Methods: Using previously described methodology, specific topics were developed relating to olfaction. Each topic was assigned a literature review, evidence-based review, or evidence-based review with recommendations format as dictated by available evidence and scope within the ICAR:O document. Following iterative reviews of each topic, the ICAR:O document was integrated and reviewed by all authors for final consensus. Results:The ICAR:O document reviews nearly 100 separate topics within the realm of olfaction, including diagnosis, epidemiology, disease burden, diagnosis, testing, etiology, treatment, and associated pathologies. Conclusion:This critical review of the existing clinical olfaction literature provides much needed insight and clarity into the evaluation, diagnosis, and treatment of patients with olfactory dysfunction, while also clearly delineating gaps in our knowledge and evidence base that we should investigate further.

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“…considered that the olfactory dysfunction in NPC patients after radiotherapy was most likely sensorineural and not conductive, but their patients received conventional radiotherapy. Veyseller et al . reported diminished volume of olfactory bulbs following radiotherapy, but all of their patients except 2 also received conventional radiotherapy.…”

Section: Discussionmentioning

confidence: 96%

“…Therefore, chronic rhinosinusitis has become 1 of the most common side effects of radiotherapy . Because the olfactory epithelium and some of the brain structure such as olfactory bulbs are included in the irradiated field, olfactory dysfunction and diminished volume of olfactory bulbs have been reported following radiotherapy . The olfactory loss was considered to be most likely sensorineural …”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Olfactory change after intensity‐modulated radiotherapy for nasopharyngeal carcinoma

Wang

Liang

Twu

et al. 2015

Int Forum Allergy Rhinol

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Olfactory bulb volume and olfactory function after radiotherapy in patients with nasopharyngeal cancer

Cited by 18 publications

References 18 publications

Evaluation of smell disorders after radiotherapy in patients with laryngeal neoplasm

Evaluation of smell disorders after radiotherapy in patients with laryngeal neoplasm

International consensus statement on allergy and rhinology: Olfaction

Olfactory change after intensity‐modulated radiotherapy for nasopharyngeal carcinoma

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