Olfactory bulbectomy distrupts the expression of cocaine-induced conditioned place preference

Calcagnetti, Daniel J.; Quatrella, Lucy A.; Schechter, Martin

doi:10.1016/0031-9384(95)02119-1

Cited by 48 publications

(16 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The blunted response to amphetamine was evident 3 weeks after the lesion, was not associated with reductions in general performance capacity (unchanged asymptotic response rates), and was present in every rat that we tested. The finding that OBX can induce an anhedonic response to a rewarding stimulus is consistent with a previous study showing that OBX can block the expression of a cocaine-induced conditioned place preference (Calcagnetti et al 1996).…”

Section: Discussionsupporting

confidence: 92%

“…Some evidence suggests that OBX also produces anhedonia (Calcagnetti et al 1996). We chose to induce anhedonia with OBX over other animal models for several reasons such as the ease of inducing and confirming the lesion, the lack of assumption concerning the role of stress in the etiology of depression, the long duration of consequent changes and their responsiveness to chronic, but not acute, antidepressant treatment (Song and Leonard 2005;van Riezen and Leonard 1990).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Simultaneous anhedonia and exaggerated locomotor activation in an animal model of depression

et al. 2009

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Simultaneous anhedonia and exaggerated locomotor activation in an animal model of depression

et al. 2009

View full text Add to dashboard Cite

show abstract

“…However, separation between locomotor and rewarding effects of cocaine has previously been demonstrated in rats (Slattery et al 2005b). Furthermore, bulbectomy has previously been demonstrated to reduce the expression of cocaine-induced place preference (Calcagnetti et al 1996), lending further support for the dissociation between locomotor and rewarding effects of cocaine.…”

Section: Discussionmentioning

confidence: 70%

Evaluation of reward processes in an animal model of depression

2006

View full text Add to dashboard Cite

Rationale Anhedonia is a core symptom of major depression. Deficits in reward function, which underlie anhedonia, can be readily assessed in animals. Therefore, anhedonia may serve as an endophenotype for understanding the neural circuitry and molecular pathways underlying depression.Objective Surprisingly, there is scant knowledge regarding alterations in brain reward function after olfactory bulbectomy (OB), an animal model which results in a behavioural syndrome responsive to chronic antidepressant treatment. Therefore, the present studies aimed to assess reward function after bulbectomy. Materials and methods The present study utilized sucrose preference, cocaine-induced hyperlocomotion and intracranial self-stimulation (ICSS) responding to examine reward processes in the OB model.Results Bulbectomized animals showed a marked preference (>90%) for 0.8% sucrose solution compared with water; similar to the preference exhibited by sham controls. Importantly, there were pronounced deficits in brain reward function, as assessed using ICSS, which lasted 8 days before returning to baseline levels. Furthermore, bulbectomized animals were hyper-responsive to the locomotor stimulating properties of an acute and a repeated cocaine regimen. However, no difference in ICSS facilitation was observed in response to an acute cocaine injection. Conclusions Taken together, these results suggest that bulbectomized rats display alterations in brain reward function, but these changes are not long-lasting and thus, not amenable to investigating the effects of pharmacological interventions. However, given that OB animals are hypersensitive to drugs of abuse, bulbectomy may be an appropriate inducing factor for the development of animal models of co-morbid depression and drug dependence.

show abstract

“…Furthermore, in rats, CMS induces an increased immobility in the FST associated with a decrease in reward sensitivity as measured by increased intracranial self-stimulation threshold, attenuated sucrose consumption, decreased preference for alcohol, impaired sexual behaviour and decreased amphetamine and morphine rewarding effects (Willner 2005). Similarly, olfactory bulbectomy that exhibits a high degree of neurochemical similarity to depression induces a decreased sensitivity to reward as shown by a decreased sexual behaviour (Lumia et al 1992), an increased intracranial self-stimulation threshold (Slattery et al 2007) and a reduced cocaine place preference (Calcagnetti et al 1996).…”

Section: Discussionmentioning

confidence: 99%

A single episode of maternal deprivation impairs the motivation for cocaine in adolescent mice

Martini

Valverde

2011

Psychopharmacology

View full text Add to dashboard Cite

show abstract

Olfactory bulbectomy distrupts the expression of cocaine-induced conditioned place preference

Cited by 48 publications

References 48 publications

Simultaneous anhedonia and exaggerated locomotor activation in an animal model of depression

Simultaneous anhedonia and exaggerated locomotor activation in an animal model of depression

Evaluation of reward processes in an animal model of depression

A single episode of maternal deprivation impairs the motivation for cocaine in adolescent mice

Contact Info

Product

Resources

About