Simultaneous anhedonia and exaggerated locomotor activation in an animal model of depression

Romeas, Thomas; Morissette, Marie-Claude; Mnie-Filali, Ouissame; Piñeyro, Graciela; Boye, Sandra M.

doi:10.1007/s00213-009-1539-y

Cited by 54 publications

(30 citation statements)

References 57 publications

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“…An exaggeration of locomotor activity in OBX animals was observed compared with sham rats when placed in a high illuminated open-field ( Figure 6). This is consistent with previous reports and is believed to be due to a deficit of habituation to a new stressful environment (Cairncross et al 1979;Van Riezen and Leonard, 1990;McNish and Davis, 1997;Song and Leonard, 2005;Romeas et al, 2009). Importantly, although fluoxetine was ineffective after a 7-day treatment (as expected for an SSRI; Lucas et al, 2007;Breuer et al, 2007), SB-269970 reversed the OBXinduced hyperactivity.…”

Section: Discussionsupporting

confidence: 92%

Pharmacological Blockade of 5-HT7 Receptors as a Putative Fast Acting Antidepressant Strategy

Mnie-Filali

Faure

Lambás‐Señas

et al. 2011

Neuropsychopharmacol

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130

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Current antidepressants still display unsatisfactory efficacy and a delayed onset of therapeutic action. Here we show that the pharmacological blockade of serotonin 7 (5-HT 7 ) receptors produced a faster antidepressant-like response than the commonly prescribed antidepressant fluoxetine. In the rat, the selective 5-HT 7 receptor antagonist SB-269970 counteracted the anxiogenic-like effect of fluoxetine in the open field and exerted an antidepressant-like effect in the forced swim test. In vivo, 5-HT 7 receptors negatively regulate the firing activity of dorsal raphe 5-HT neurons and become desensitized after long-term administration of fluoxetine. In contrast with fluoxetine, a 1-week treatment with SB-269970 did not alter 5-HT firing activity but desensitized cell body 5-HT autoreceptors, enhanced the hippocampal cell proliferation, and counteracted the depressive-like behavior in olfactory bulbectomized rats. Finally, unlike fluoxetine, early-life administration of SB-269970, did not induce anxious/depressive-like behaviors in adulthood. Together, these findings indicate that the 5-HT 7 receptor antagonists may represent a new class of antidepressants with faster therapeutic action.

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Section: Discussionsupporting

confidence: 92%

Pharmacological Blockade of 5-HT7 Receptors as a Putative Fast Acting Antidepressant Strategy

Mnie-Filali

Faure

Lambás‐Señas

et al. 2011

Neuropsychopharmacol

Self Cite

130

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“…This behavioral paradigm is based on the discovery by Olds and Milner that rats will repeatedly press a lever to stimulate specific components of the brain reward circuit (Olds and Milner 1954). A number of studies have confirmed the validity of this technique for the assessment of both the rewarding and the anhedonic effects of drugs or other manipulations (Benaliouad et al 2007;Gallo et al 2010;Kornetsky 1985;Markou and Koob 1991;Morissette and Boye 2008;Paterson et al 2000;Romeas et al 2009;Slattery et al 2007;Wise 1996). Most drugs of abuse are able to lower the brain stimulation reward threshold, an effect which supports the notion that they activate the same substrate with electrical stimulation in a synergistic manner (Wise 1996(Wise , 1998.…”

Section: Introductionmentioning

confidence: 96%

Role of serotonin 5-HT2A and 5-HT2C receptors on brain stimulation reward and the reward-facilitating effect of cocaine

2010

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“…This may be one explanation for the uncommon constellation of behaviours observed in our study. However, recently, a cooccurrence of behavioural activation after stress-induced anhedonia has been documented by others [100,101] and warrants further exploration. Selection for phenotypic variation in exploratory activity produced no major interactions with chronic stress; however, LE rats were somewhat more strongly affected by CVS in their weight gain and differed in their second-day FST behaviour.…”

Section: Discussionmentioning

confidence: 99%

Activating Effects of Chronic Variable Stress in Rats with Different Exploratory Activity: Association with Dopamine D1 Receptor Function in Nucleus Accumbens

Matrov¹,

Vonk

Herm

et al. 2011

Neuropsychobiology

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Background/Aims: Rats display persistent behavioural phenotypes of low (LE) versus high (HE) exploratory activity in the exploration box paradigm. LE rats that prefer passive coping strategies show differential dopaminergic activity in the striatum. The main hypothesis of this study was that chronic variable stress (CVS) would have a higher impact on LE rats. Methods: Animals were submitted to a CVS regimen lasting 32 days that was followed by a behavioural test battery. The functional states of their dopamine D₁ and D₂ receptors were measured in the striatum and nucleus accumbens (NAcc). Cerebral oxidative metabolism was assessed via cytochrome c oxidase histochemistry in 65 brain regions. Results: CVS decreased weight gain, to a higher extent in LE rats, and lowered the sucrose preference after the first week, but habituation to the anhedonic effect had developed by the end of the experiment. CVS did not change the behavioural phenotypes initially assigned. No effect of stress on D₂ receptor function was found. Chronically stressed animals exhibited higher levels of social interaction and D₁ receptor-mediated cAMP accumulation in the NAcc, but not in the striatum. CVS was associated with higher oxidative metabolism levels in the anteroventral thalamus, median raphe nuclei and central periaqueductal grey matter. These changes after stress did not depend upon the exploratory phenotype. Conclusion: This study revealed changes in brain biochemistry after habituation to CVS that might be implicated in successful adaptation to chronic stress.

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Simultaneous anhedonia and exaggerated locomotor activation in an animal model of depression

Cited by 54 publications

References 57 publications

Pharmacological Blockade of 5-HT7 Receptors as a Putative Fast Acting Antidepressant Strategy

Pharmacological Blockade of 5-HT7 Receptors as a Putative Fast Acting Antidepressant Strategy

Role of serotonin 5-HT2A and 5-HT2C receptors on brain stimulation reward and the reward-facilitating effect of cocaine

Activating Effects of Chronic Variable Stress in Rats with Different Exploratory Activity: Association with Dopamine D1 Receptor Function in Nucleus Accumbens

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