Olfactory ensheathing cell transplantation for a patient with chronic sciatic nerve injury

Zhang, Feng; Meng, Xiangzhi; Lu, Fang; Liu, Aixian; Huang, Hongyun

doi:10.2147/jn.s120524

Cited by 3 publications

(2 citation statements)

References 19 publications

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“…A number of clinical studies concerning cell therapies with a positive outcome have led to the suggestion that combination cell therapies and/or certain transplantation approaches with rehabilitation can be more effective 107 , 123 , 128 – 130 , 136 , 138 – …”

Section: Provisionsmentioning

confidence: 99%

Clinical Cell Therapy Guidelines for Neurorestoration (IANR/CANR 2017)

et al. 2018

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Cell therapy has been shown to be a key clinical therapeutic option for central nervous system diseases or damage. Standardization of clinical cell therapy procedures is an important task for professional associations devoted to cell therapy. The Chinese Branch of the International Association of Neurorestoratology (IANR) completed the first set of guidelines governing the clinical application of neurorestoration in 2011. The IANR and the Chinese Association of Neurorestoratology (CANR) collaborated to propose the current version “Clinical Cell Therapy Guidelines for Neurorestoration (IANR/CANR 2017)”. The IANR council board members and CANR committee members approved this proposal on September 1, 2016, and recommend it to clinical practitioners of cellular therapy. These guidelines include items of cell type nomenclature, cell quality control, minimal suggested cell doses, patient-informed consent, indications for undergoing cell therapy, contraindications for undergoing cell therapy, documentation of procedure and therapy, safety evaluation, efficacy evaluation, policy of repeated treatments, do not charge patients for unproven therapies, basic principles of cell therapy, and publishing responsibility.

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Section: Provisionsmentioning

confidence: 99%

Clinical Cell Therapy Guidelines for Neurorestoration (IANR/CANR 2017)

et al. 2018

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“…The presence of active neurogenesis in the adult human nervous system, except for the olfactory neuroepithelium, is still controversial. [52][53][54], multiple system atrophy (MSA) [55], postpoliomyelitis syndrome [56], SCI [57][58][59][60], and sciatic nerve injury [61].…”

Section: The Basic Characterization Of the Olfactory Neuroepitheliummentioning

confidence: 99%

Why is olfactory neuroepithelium?

Huang¹

2021

Journal of Neurorestoratology

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Currently, most cellular therapeutic effects for nervous diseases cannot be proven in a multicenter, randomized, double-blind placebo-control clinical trials, except for a few kinds of cells such as olfactory ensheathing cells. These cells show significant improvements in functional recovery and quality of life for patients with chronic ischemic stroke. Also, olfactory neuron transplantation has promising neurorestorative effects on patients with vascular dementia. Human olfactory neuroepithelium can spontaneously and sustainably regenerate or produce new olfactory neurons and glial cell types for decades or a lifetime. The neurorestorative mechanisms of olfactory ensheathing cells are well known; however, little is known about the neurorestorative mechanisms of olfactory neurons. Therefore, I hypothesize that the neurorestorative mechanisms of olfactory neurons after transplantation: (1) can well migrate where they are needed and become local functional neurons, as they need to compensate or replace; (2) must be regulated by some special molecular factors to elongate their axons, modulate or direct synapses to correctly recognize and connect the target cells, and integrate functions. Based on olfactory neuroepithelium cells displaying the special characterization, neurorestorative mechanisms, clinical therapeutic achievements, and hypotheses of effective mechanisms, they (olfactory ensheathing cells and olfactory neurons) may be the most efficient instruments of neurorestoration.

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Clinical neurorestorative cell therapies: Developmental process, current state and future prospective

Huang

Chen

Mao

et al. 2020

Journal of Neurorestoratology

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Clinical cell therapies (CTs) for neurological diseases and cellular damage have been explored for more than 2 decades. According to the United States Food and Drug Administration, there are 2 types of cell categories for therapy, namely stem cell-derived CT products and mature/functionally differentiated cell-derived CT products. However, regardless of the type of CT used, the majority of reports of clinical CTs from either small sample sizes based on single-center phase 1 or 2 unblinded trials or retrospective clinical studies showed effects on neurological improvement and the ability to either partially or temporarily thwart the deteriorating cellular processes of the neurodegenerative diseases. There have been only a few prospective, multicenter, randomized, double- blind placebo-control clinical trials of CTs so far in this developing novel area that have shown negative results, and more clinical trials are needed. This will expand our knowledge in exploring the type of cells that yield promising results and restore damaged neurological structure and functions of the central nervous system based on higher level evidence-based medical data. In this review, we briefly introduce the developmental process, current state, and future prospective for clinical neurorestorative CT.

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Olfactory ensheathing cell transplantation for a patient with chronic sciatic nerve injury

Cited by 3 publications

References 19 publications

Clinical Cell Therapy Guidelines for Neurorestoration (IANR/CANR 2017)

Clinical Cell Therapy Guidelines for Neurorestoration (IANR/CANR 2017)

Why is olfactory neuroepithelium?

Clinical neurorestorative cell therapies: Developmental process, current state and future prospective

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