Olfactory functioning in panic disorder

Burón, Emma; Bulbena, Antonio; Bulbena-Cabré, Andrea

doi:10.1016/j.jad.2015.01.049

Cited by 30 publications

(25 citation statements)

References 62 publications

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“…To avoid confounding psychological effects on olfactory perception and sensitivity (Atanasova et al, ; Burón, Bulbena, & Bulbena‐Cabré, ; Croy et al, ; Naudin & Atanasova, ; Yuan & Slotnick, ) and to assess clinical impairment in healthy participants, the following questionnaires were used: the German version of the Beck Depression Inventory II (BDI) (Hautzinger, Keller, & Kühner, ), autism questionnaire (Baron‐Cohen, Wheelwright, Skinner, Martin, & Clubley, ), and a German questionnaire for personality style and disorders (Persönlichkeits‐Stil und Störungs‐Inventar; Kuhl & Kazén, ). Additional tests were conducted in order to compare the two groups: verbal intelligence quotient (IQ) using the German Wortschatztest (Schmidt & Metzler, ), executive functions via the Trail Making Test (Reitan, ), word fluency using the German Regensburger Wortflüssigkeitstest (Aschenbrenner, Tucha, & Lange, ), Emotion Recognition 40 (Gur et al, ; Hoheisel & Kryspin‐Exner, ), and the German version of the Wechsler Memory Scale (Härtling et al, ).…”

Section: Methodsmentioning

confidence: 99%

“…To avoid confounding psychological effects on olfactory perception and sensitivity (Atanasova et al, 2008;Burón, Bulbena, & Bulbena-Cabré, 2015;Croy et al, 2014;Naudin & Atanasova, 2014;Yuan & Slotnick, 2014) and to assess clinical impairment in healthy participants, the following questionnaires were used: the German version of the Beck Depression Inventory II (BDI) (Hautzinger, Keller, & Kühner, 2006), autism questionnaire (Baron-Cohen, Wheelwright, Skinner, Martin, & Clubley, 2001), and a German questionnaire for personality style and disorders (Persönlichkeits-Stil und Störungs-Inventar; Kuhl & Kazén, 2009).…”

Section: Participantsmentioning

confidence: 99%

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Audio–visual and olfactory–visual integration in healthy participants and subjects with autism spectrum disorder

Stickel

Weismann

Kellermann

et al. 2019

Human Brain Mapping

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The human capacity to integrate sensory signals has been investigated with respect to different sensory modalities. A common denominator of the neural network underlying the integration of sensory clues has yet to be identified. Additionally, brain imaging data from patients with autism spectrum disorder (ASD) do not cover disparities in neuronal sensory processing. In this fMRI study, we compared the underlying neural networks of both olfactory–visual and auditory–visual integration in patients with ASD and a group of matched healthy participants. The aim was to disentangle sensory‐specific networks so as to derive a potential (amodal) common source of multisensory integration (MSI) and to investigate differences in brain networks with sensory processing in individuals with ASD. In both groups, similar neural networks were found to be involved in the olfactory–visual and auditory–visual integration processes, including the primary visual cortex, the inferior parietal sulcus (IPS), and the medial and inferior frontal cortices. Amygdala activation was observed specifically during olfactory–visual integration, with superior temporal activation having been seen during auditory–visual integration. A dynamic causal modeling analysis revealed a nonlinear top‐down IPS modulation of the connection between the respective primary sensory regions in both experimental conditions and in both groups. Thus, we demonstrate that MSI has shared neural sources across olfactory–visual and audio–visual stimulation in patients and controls. The enhanced recruitment of the IPS to modulate changes between areas is relevant to sensory perception. Our results also indicate that, with respect to MSI processing, adults with ASD do not significantly differ from their healthy counterparts.

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Section: Methodsmentioning

confidence: 99%

Section: Participantsmentioning

confidence: 99%

Audio–visual and olfactory–visual integration in healthy participants and subjects with autism spectrum disorder

Stickel

Weismann

Kellermann

et al. 2019

Human Brain Mapping

View full text Add to dashboard Cite

show abstract

“…A growing literature indicates structural and functional changes of the olfactory system with fear and threat ( Ahs et al, 2013 , Jones et al, 2008 , Kass et al, 2013 ), as well as olfactory differences with anxiety ( La Buissonniere-Ariza et al, 2013 , Takahashi et al, 2015 ) and fear-related disorders, including posttraumatic stress disorder (PTSD) ( Berlin et al, 2017 , Buron et al, 2015 , Cortese et al, 2015b , Dileo et al, 2008 , Vasterling et al, 2000 ). These observations suggest a linkage between the neurobiology of olfactory function and anxiety-fear systems.…”

Section: Introductionmentioning

confidence: 99%

Preliminary evidence for differential olfactory and trigeminal processing in combat veterans with and without PTSD

Cortese¹,

Schumann²,

Howell³

et al. 2018

NeuroImage: Clinical

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Structural and functional changes in the olfactory system are increasingly implicated in the expression of PTSD. Still, very little is known about the neurobiological networks of trauma-related odor sensitivity or how they relate to other objective and subjective measures of olfaction and PTSD. The purpose of this study was to replicate prior findings and further characterize olfactory function in trauma-exposed combat veterans with and without PTSD. We also sought to extend this area of research by exploring the effects of time since the combat-related index trauma (TST) on post-trauma olfactory function, as well as by correlating odor-elicited brain activity to general olfactory ability and odor-elicited PTSD symptoms. Participants included combat veterans with PTSD (CV+PTSD; n = 21) or without any psychiatric disorder (CV-PTSD; n = 27). TST was coded as greater (n = 24) or less (n = 24) than 5 years. There were main effects and/or interaction for PTSD-status and TST across several parameters of olfactory function: odor detection, odor identification, ratings for trauma-related odor intensity and triggered PTSD symptoms, and trauma odor-elicited brain activation. Overall, results suggest olfactory impairment in chronic PTSD, but not necessarily in the earlier stages of the disorder, although some early-stage olfactory findings may be predictive of later olfactory impairment. Results also suggest that trauma-exposed individuals who never develop PTSD may demonstrate olfactory resiliency. Finally, results highlight a potentially unique role of trigeminal odor properties in the olfactory-PTSD relationship.

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“…12,13 Odor detection/sensitivity across stress, anxiety, and other fear-related disorders is equally mixed. [14][15][16][17][18][19] Taken together, these findings suggest that additional variables may moderate the relationship between fear/threat and enhanced odor detection/ sensitivity in humans. For instance, our research suggests that situations of real, life-threatening danger may shift olfactory system functions toward the more sensitive detection of specific, threat-related odor cues, including burning odors.…”

Section: Introductionmentioning

confidence: 78%

Odor sensitivity impairment: a behavioral marker of psychological distress?

et al. 2018

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ObjectiveEnhanced odor sensitivity, particularly toward threat-related cues, may be adaptive during periods of danger. Research also suggests that chronic psychological distress may lead to functional changes in the olfactory system that cause heightened sensitivity to odors. Yet, the association between self-reported odor sensitivity, objective odor detection, and affective psychopathology is currently unclear, and research suggests that persons with affective problems may only be sensitive to specific, threat-related odors.MethodsThe current study compared adults with self-reported odor sensitivity that was described as functionally impairing (OSI; n = 32) to those who reported odor sensitivity that was non-impairing (OS; n = 17) on affective variables as well as quantitative odor detection.ResultsIncreased anxiety sensitivity, trait anxiety, depression, and life stress, even while controlling for comorbid anxiety and depressive disorders, was found for OSI compared to OS. While OSI, compared to OS, demonstrated only a trend increase in objective odor detection of a smoke-like, but not rose-like, odor, further analysis revealed that increased detection of that smoke-like odor was positively correlated with anxiety sensitivity.ConclusionThese findings suggest that persons with various forms of psychological distress may find themselves significantly impaired by an intolerance of odors, but that self-reported odor sensitivity does not necessarily relate to enhanced odor detection ability. However, increased sensitivity to a smoke-like odor appears to be associated with sensitivity to aversive anxiogenic stimuli. Implications for the pathophysiology of fear- and anxiety-related disorders are discussed.

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Olfactory functioning in panic disorder

Cited by 30 publications

References 62 publications

Audio–visual and olfactory–visual integration in healthy participants and subjects with autism spectrum disorder

Audio–visual and olfactory–visual integration in healthy participants and subjects with autism spectrum disorder

Preliminary evidence for differential olfactory and trigeminal processing in combat veterans with and without PTSD

Odor sensitivity impairment: a behavioral marker of psychological distress?

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