Oligo(3-hydroxybutanoate) conjugates with acetylsalicylic acid and their antitumour activity

Synthesis and Structural Characterization of Bioactive PHA and γ-PGA Oligomers for Potential Applications as a Delivery System

“…Recently, ESI-MS has been successfully applied in the structural studies of conjugates of biodegradable oligomers and bioactive substances, such as food preservatives [24], herbicides [25,26], non-steroidal anti-inflammatory drugs [27,28], or antioxidants used in cosmetology [29,30,31]. …”

Characterisation of a novel conjugate of ibuprofen with 3-hydroxybutyric acid oligomers

“…A novel system of this type of conjugate using ibuprofen together with oligomers of 3‐hydroxybutyric acid (OHBs) has recently been synthesised and patented in the Centre of Polymer and Carbon Materials of the Polish Academy of Sciences in Zabrze, Poland (Patent PL 196384) 9 . The synthesis of the ibuprofen–OHB conjugate, using methods similar to those previously described for conjugation of acetylsalicylic acid, 10 resulted in an amorphous, viscous, semisolid, transparent substance. Its chemical structure, illustrated in Figure 1, has been confirmed by gel‐permeation chromatography, 1 H NMR, electrospray ionisation mass spectrometry (ESI‐MS) and infrared spectroscopy.…”

Structural characterization of biocompatible lipoic acid–oligo‐(3‐hydroxybutyrate) conjugates by electrospray ionization mass spectrometry

“…Detailed mass spectrometry studies on the oligo(3‐hydroxybutyrate) covalently bound to penicillin G, obtained via anionic ring‐opening oligomerization (ROO) of β‐butyrolactone, have been reported . Using the same approach, aspirin‐ and ibuprofen‐OHB conjugates have been prepared recently, both of which were found to be less toxic than the free drug compounds …”