Oligodendrocyte development in the embryonic brain: the contribution of the plp  lineage

Bras, Barbara Le; Chatzopoulou, Elli; Heydon, Katharina; Martı́nez, Salvador; Ikenaka, K.; Prestoz, Laetitia; Spassky, Nathalie; Zalc, Bernard; Thomas, Jean‐Léon

doi:10.1387/ijdb.041963bl

Cited by 45 publications

(46 citation statements)

References 96 publications

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“…It is not clear whether this variation reflects intrinsic differences among oligodendrocyte subtypes or phenotypic plasticity. Heterogeneity has also been proposed on the basis of expression of markers such as Pdgfra or PLP/DM20 (Le Bras et al 2005). The possibility that there might be different functional subclasses of oligodendrocyte becomes more intriguing owing to the discovery of dorsally derived as well as ventrally derived OLPs and the likelihood that these are specified by different signals (Chandran et al 2003;Kessaris et al 2004).…”

Section: (D) Oligodendrocyte Diversity?mentioning

confidence: 99%

Specification of CNS glia from neural stem cells in the embryonic neuroepithelium

Kessaris

Pringle

Richardson

2007

Phil. Trans. R. Soc. B

115

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All the neurons and glial cells of the central nervous system are generated from the neuroepithelial cells in the walls of the embryonic neural tube, the 'embryonic neural stem cells'. The stem cells seem to be equivalent to the so-called 'radial glial cells', which for many years had been regarded as a specialized type of glial cell. These radial cells generate different classes of neurons in a positiondependent manner. They then switch to producing glial cells (oligodendrocytes and astrocytes). It is not known what drives the neuron-glial switch, although downregulation of pro-neural basic helixloop-helix transcription factors is one important step. This drives the stem cells from a neurogenic towards a gliogenic mode. The stem cells then choose between developing as oligodendrocytes or astrocytes, of which there might be intrinsically different subclasses. This review focuses on the different extracellular signals and intracellular responses that influence glial generation and the choice between oligodendrocyte and astrocyte fates.

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Section: (D) Oligodendrocyte Diversity?mentioning

confidence: 99%

Specification of CNS glia from neural stem cells in the embryonic neuroepithelium

Kessaris

Pringle

Richardson

2007

Phil. Trans. R. Soc. B

115

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“…Two distinct types of neural cells, the inhibitory GABAergic neurons and the oligodendrocytes, that eventually help populate the dorsal telencephalon, arise from this spatially, temporally and molecularly delimited 'common' pool of NPCs Le Bras et al, 2005;Miller, 2002;Wonders and Anderson, 2006;Yue et al, 2006). Generation of these different cell types in proper ratios and at correct times is important for normal development of the telencephalon.…”

Section: Introductionmentioning

confidence: 99%

The Wnt receptor Ryk controls specification of GABAergic neurons versus oligodendrocytes during telencephalon development

et al. 2011

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SUMMARYGABAergic neurons and oligodendrocytes originate from progenitors within the ventral telencephalon. However, the molecular mechanisms that control neuron-glial cell-fate segregation, especially how extrinsic factors regulate cell-fate changes, are poorly understood. We have discovered that the Wnt receptor Ryk promotes GABAergic neuron production while repressing oligodendrocyte formation in the ventral telencephalon. We demonstrate that Ryk controls the cell-fate switch by negatively regulating expression of the intrinsic oligodendrogenic factor Olig2 while inducing expression of the interneuron fate determinant Dlx2. In addition, we demonstrate that Ryk is required for GABAergic neuron induction and oligodendrogenesis inhibition caused by Wnt3a stimulation. Furthermore, we showed that the cleaved intracellular domain of Ryk is sufficient to regulate the cell-fate switch by regulating the expression of intrinsic cell-fate determinants. These results identify Ryk as a multifunctional receptor that is able to transduce extrinsic cues into progenitor cells, promote GABAergic neuron formation, and inhibit oligodendrogenesis during ventral embryonic brain development.

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“…The first astrocytes arrive in the OB around birth and at least some of them use tangential migration from the SVZ through the RMS (Law et al, 1999). Oligodendrocyte progenitor cells (OPCs) are heterogeneous and have multiple origins in the developing forebrain (Chong and Chan, 2010;Le Bras et al, 2005;Spassky et al, 2001;Woodruff et al, 2001). One population expressing the myelin proteolipid protein 1 (Plp1)-driven transgene is detected in the OB already at E14.5, whilst a platelet-derived growth factor receptor α (Pdgfra)-expressing population appears at E16.5 (Spassky et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Netrin1 is required for neural and glial precursor migrations into the olfactory bulb

Hakanen

Duprat

Salminen

2011

Developmental Biology

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Netrin1 (NTN1) deficiency in mouse brain causes defects in axon guidance and cell migration during embryonic development. Here we show that NTN1 is required for olfactory bulb (OB) development at late embryogenesis and at early postnatal stages to facilitate the accumulation of proper numbers of granular and glomerular neuron subtypes and oligodendrocytes into the OB. In addition to the analysis of Ntn1-/- mice we made tissue and neurosphere cultures to clarify the role of NTN1 in the anterior forebrain. We propose that a subset of neural progenitors/precursors requires NTN1 to efficiently enter the rostral migratory stream to migrate into the OB. The analysis of postnatal Ntn1-/- OBs revealed a reduction of specific types of interneurons which have been shown to originate from particular subregions of the lateral ventricle walls. Based on Ntn1 expression in ventral parts of the ventricle walls, we observed a decrease in the mainly ventrally derived type II interneurons that express calcium-binding proteins calretinin and calbindin. Instead, no change in the numbers of dorsally derived tyrosine hydroxylase expressing interneurons was detected. In addition to the specific reduction of type II interneurons, our results indicate that NTN1 is required for oligodendroglial migration into the OB. Furthermore, we characterised the Ntn1 expressing subpopulation of neurosphere-forming cells from embryonic and adult brain as multipotent and self-renewing. However, NTN1 is dispensable for the proliferation of neurosphere forming progenitor cells and for their differentiation.

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Oligodendrocyte development in the embryonic brain: the contribution of the plp lineage

Cited by 45 publications

References 96 publications

Specification of CNS glia from neural stem cells in the embryonic neuroepithelium

Specification of CNS glia from neural stem cells in the embryonic neuroepithelium

The Wnt receptor Ryk controls specification of GABAergic neurons versus oligodendrocytes during telencephalon development

Netrin1 is required for neural and glial precursor migrations into the olfactory bulb

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