Oligodendroglioma Arising in Mature Cystic Teratoma

Ünal, Betül; Güleç, Faruk; Sedele, Murat

doi:10.1155/2014/745462

Cited by 5 publications

(4 citation statements)

References 9 publications

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“…These features are characteristics of tertiary lymphoid organs, that have already been reported in other tumors [13] and are believed to be generated as a result of local antigen presentation in a context of chronic inflammation and to perpetuate adaptive immune responses providing local source for antibody production [12]. Herein, we observed immunoglobulin deposits and immunoglobulin secreting cells in direct contact with the nervous tissue of NMDAR-teratomas, while previous studies had already detected plasma cells in NMDAR-teratomas [19, 32]. The presence of the B-cell response effectors in the tumor associated with B-mediated immunity supported the idea that in young females with NMDAR-E and ovarian teratoma, the tumor triggers the anti-NMDAR immune reaction.…”

Section: Discussionsupporting

confidence: 63%

Immunopathological characterization of ovarian teratomas associated with anti-N-methyl-D-aspartate receptor encephalitis

Chefdeville

Treilleux

Mayeur

et al. 2019

acta neuropathol commun

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Encephalitis with anti-NMDAR antibodies (NMDAR-E) is a severe autoimmune neurological disorder, defined by a clinical presentation of encephalitis and the presence of IgG targeting the GluN1 subunit of NMDA receptors in the CSF. An underlying ovarian teratoma is commonly associated with this autoimmune disease suggesting a role of the tumor in immunopathogenesis. In this study, we characterized the salient histopathological features of 27 ovarian teratomas associated with NMDAR-E (3 immature and 24 mature teratomas) and 40 controls without associated encephalitis. All but one NMDAR-E-associated teratomas contained a nervous tissue component, while less than 40% of control teratomas did (p < 0.001). GluN1 expression by teratomatous nervous tissue seemed to be more often glial in NMDAR-E teratomas than in control teratomas (73% vs. 29%, p < 0.05). Strikingly, 3 out of 24 NMDAR-E-associated mature teratomas contained neuroglial tissue exhibiting histopathological features of central nervous system neuroglial tumor, while such glioma-like features are exceptionally described in the literature on ovarian teratomas. Moreover, NMDAR-E associated teratomas differed from sporadic ovarian teratomas by consistent and prominent infiltration of the nervous tissue component by immune cells, comprised of T- and B-cells and mature dendritic cells organized in tertiary lymphoid structures, with IgG and IgA deposits and plasma cells in close contact to the neuroglial tissue.These data demonstrate an association between massive infiltration of NMDAR-E-associated teratomas by immune cells and particular glial features of its neuroglial component, suggesting that this glial tissue might be involved in triggering or sustaining the anti-tumor response associated with the auto-immune neurological disease.Electronic supplementary materialThe online version of this article (10.1186/s40478-019-0693-7) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 63%

Immunopathological characterization of ovarian teratomas associated with anti-N-methyl-D-aspartate receptor encephalitis

Chefdeville

Treilleux

Mayeur

et al. 2019

acta neuropathol commun

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“…Squamous cell carcinoma is the most common type [ 16 , 21 ]. Other less frequent malignant transformations include mucinous carcinoma [ 21 ], adenocarcinoma [ 22 , 23 , 24 , 25 , 26 ], melanoma [ 27 ], carcinoid [ 28 , 29 , 30 ], oligodendroglioma [ 31 , 32 , 33 ], and sarcoma [ 34 , 35 , 36 , 37 ].…”

Section: Epidemiologymentioning

confidence: 99%

“…Although imaging examinations can diagnose MCTs with considerable accuracy, tissue examination is necessary to exclude any malignancy [ 11 ]. The majority of malignant transformations are squamous-cell carcinomas, while the remainders are carcinoid tumors, adenocarcinomas, melanoma [ 27 ], oligodendroglioma [ 31 , 32 , 33 ], and sarcoma [ 16 , 34 , 35 , 36 , 37 , 83 , 84 , 85 ]. The treatments for these malignant transformations are the same as for ovarian carcinoma, including surgical removal and chemotherapy.…”

Section: Treatmentmentioning

confidence: 99%

Mature Cystic Teratoma: An Integrated Review

Cong

Wang

Yeung

et al. 2023

IJMS

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Ovarian dermoid cysts, also called mature cystic teratomas (MCTs), account for 69% of ovarian germ cell tumors in young women. The tumors are formed by tissues derived from three germ layers, and sebaceous materials are most commonly seen. The origin of MCTs is widely considered to be the germ cell origin, which completes meiosis I. The clinical symptoms vary widely, but 20% of tumors could be asymptomatic. The diagnosis of MCTs is usually made without difficulty by ultrasound and confirmed by histopathology post-operatively. The imaging findings have a high diagnostic value. The typical characteristics present in the sonographic images, including a dermoid plug or Rokitansky nodule, are considered strong evidence for a teratoma. Although the malignant transformation of MCTs is rare, it can occur in some cases, especially in women of advanced age. The treatment of MCTs depends on the risk of malignancy, the age of the patient, and the patient’s fertility reserve requirement. In this article, we review the epidemiology, clinical symptoms, diagnosis criteria, cellular origin, and treatment of mature cystic teratomas.

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“…희소돌기아교세포종(oligodendroglioma)은 원시 신경외배엽세 포에서 기원하는 신경상피양 종양으로, 희소돌기아교세포로 구성 되어 있는 악성 신경교종의 한 형태이다. 전체 원발 뇌종양의 4.2% 정도를 차지하며, 주로 청장년층 환자의 대뇌반구에서 특징적으로 발생한다 1,2) . 기형종(teratoma)은 소아에서 발견되는 가장 흔한 생 식세포 종양으로, 천미부 기형종(sacrococcygeal teratoma)의 경 우 신생아에서 가장 흔한 고형 종양 중 하나로 알려져 있다.…”

Section: 서론unclassified

A Rare Case of Oligodendroglioma in Sacrococcygeal Mature Teratoma Diagnosed in Preterm Infant

Jeong

Hwang

et al. 2022

Neonatal Med

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Sacrococcygeal teratoma is the most common congenital tumor in neonates, and is reported in approximately 1/35,000 to 1/40,000 live births. Oligodendroglioma is a rare central nervous system tumor that is usually found in the cerebral hemisphere of young and middle aged adults. When associated with a teratoma, it is mainly identified in ovarian teratoma in adolescents and adults. We describe a rare case of a preterm infant with oligodendroglioma in a mature sacrococcygeal teratoma. The male neonate was born at a gestational age of 30 weeks with a protruding mass in the sacrococcygeal region. Pelvic magnetic resonance imaging showed a sacrococcygeal teratoma of approximately 11 cm comprising fat components and skeletal structure, that extended from the anterior part of the sacrum to the abdominal cavity. Radical resection was performed at 36 days of age. Macroscopically, the resected intra-abdominal mass had the characteristics of a cystic lesion, and the intrapelvic mass was a predominantly solid mixed cystic-solid lesion. Histologically, this solid lesion in the intrapelvic mass was composed of mature glial tissue, which comprised as a proliferation of monotonous cells with small and round nuclei, surrounded by a perinuclear halo (“fried egg” appearance). Additionally, these cells were immunohistochemically positive for glial fibrillary acidic protein. These findings confirmed the diagnosis of oligodendroglioma in sacrococcygeal mature teratoma. After the treatment, no recurrence was observed during the follow-up period, and no additional intervention was required. However, the patient is undergoing treatment for voiding dysfunction caused by a neurogenic bladder.

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Oligodendroglioma Arising in Mature Cystic Teratoma

Cited by 5 publications

References 9 publications

Immunopathological characterization of ovarian teratomas associated with anti-N-methyl-D-aspartate receptor encephalitis

Immunopathological characterization of ovarian teratomas associated with anti-N-methyl-D-aspartate receptor encephalitis

Mature Cystic Teratoma: An Integrated Review

A Rare Case of Oligodendroglioma in Sacrococcygeal Mature Teratoma Diagnosed in Preterm Infant

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