Oligomeric proanthocyanidins attenuate airway inflammation in asthma by inhibiting dendritic cells maturation

Li, Ye-Shan; Yu, Qijun; Zhao, Wenxue; Zhang, Jiaxiang; Li, Wentao; Huang, Mao; Zeng, Xianlu

doi:10.1016/j.molimm.2017.09.012

Cited by 26 publications

(10 citation statements)

References 39 publications

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“…Asthma is a chronic airway inflammatory disease, which is mainly regulated by airway inflammatory cells and dominated by bronchial asthma ( 1 , 2 ). The incidence of asthma is affected jointly by the environment, genetics and immune function, whose main clinical manifestations are recurrent asthma and cough.…”

Section: Introductionmentioning

confidence: 99%

Association of vitamin�D receptor expression with inflammatory changes and prognosis of asthma

Chen

2018

Exp Ther Med

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The expression level of vitamin D receptor in patients with asthma was investigated to study the association between vitamin D receptor and inflammatory changes in asthma. Thirty patients with bronchial asthma treated in the Tianjin Hospital of ITCWM Nankai Hospital were selected as the experimental group, while 30 healthy individuals were selected as the control group. The mRNA expression level of vitamin D receptor in blood was detected via reverse transcription-quantitative polymerase chain reaction (RT-qPCR). The protein expression level of vitamin D receptor in blood was detected via western blot analysis and the levels of inflammatory factors were detected via enzyme-linked immune sorbent assay (ELISA). Correlations between the expression level of vitamin D and inflammatory factors were studied via Pearsons analysis. Finally, the prognoses of patients were recorded and analyzed. The results showed that the mRNA and protein expression levels of vitamin D receptor in the experimental group were significantly lower than those in control group (P<0.01). The content of 25-(OH) D3 in serum in the experimental group was significantly lower than that in the control group (P<0.01). The contents of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in serum in the experimental group were obviously higher than those in the control group, but the contents of IL-10 and transforming growth factor-β (TGF-β) were obviously lower than those in the control group (P<0.01). Moreover, the correlation analysis revealed that IL-6 and TNF-α were negatively correlated with the expression of vitamin D receptor (P<0.05), whereas IL-10 and TGF-β were positively correlated with the expression of vitamin D receptor (P<0.05). In conclusion, the expression of vitamin D receptor is positively correlated with the levels of pro-inflammatory factors. Moreover, the vitamin D receptor affects the prognosis and recovery of lung function of patients with asthma.

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Section: Introductionmentioning

confidence: 99%

Association of vitamin�D receptor expression with inflammatory changes and prognosis of asthma

Chen

2018

Exp Ther Med

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“…This nutraceutical regimen led to an amelioration of CAD cutaneous manifestations. In addition, the flavonoid polymer oligomeric proanthocyanidins reduced airway inflammation, Th2 cytokine release and antigen presentation in a mouse model of asthma [213]. In another series of reports, evidence has been provided that flavones, such as luteolin and tetramethoxyluteolin acted on mast cells, decreasing release of histamine and PGD2, which are mediators implicated in asthma pathogenesis [214,215].…”

Section: Allergy and Autoimmune Diseasesmentioning

confidence: 99%

Recent Advances on the Anti-inflammatory and Anti-oxidant properties of Red Grape Polyphenols: In Vitro and in Vivo Studies

Magrone¹,

Magrone²,

Russo³

et al. 2019

Preprint

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In this review, special emphasis will be placed on red grape polyphenols for their anti-oxidant and anti-inflammatory activities. Therefore, their capacity to inhibit major pathways responsible for activation of oxidative systems and expression and release of pro-inflammatory cytokines and chemokines will be discussed. Furthermore, regulation of immune cells by polyphenols will be illustrated with special reference to the activation of T regulatory cells which support a tolerogenic pathway at intestinal level. Furthermore, the effects of red grape polyphenols will be analyzed in obesity, as a low grade systemic inflammation. Also, possible modifications of inflammatory bowel disease biomarkers and clinical course have been studied upon polyphenol administration, either in animal models or in clinical trials. Moreover, the ability of polyphenols to cross the blood-brain barrier has been exploited to investigate their neuroprotective properties. In cancer, polyphenols seem to exert several beneficial effects, even if conflicting data are reported about their influence on T regulatory cells. Finally, the effects of polyphenols have been evaluated in experimental models of allergy and autoimmune diseases. Conclusively, red grape polyphenols are endowed with a great anti-oxidant and anti-inflammatory potential but some issues, such as polyphenol bioavailability, activity of metabolites and interaction with microbiota, deserve deeper studies.

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“…Flavonoids can have an impact on cell signaling, because they can bind to the IL-17 receptor and attenuate its signaling. Oligomeric proanthocyanidins decrease expression of CD83 molecule and that inhibit maturation of pulmonary dendritic cells (DCs) [ 199 ]. Luteolin ( 1 ) ( Figure 1 ) was found to decrease the release of histamine and prostaglandin D from mast cells [ 200 ].…”

Section: Flavonoids Coumarins and Chromones As Anti-oxidative And Anti-inflammatory Agentsmentioning

confidence: 99%

Overview of the Antioxidant and Anti-Inflammatory Activities of Selected Plant Compounds and Their Metal Ions Complexes

et al. 2021

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Numerous plant compounds and their metal-ion complexes exert antioxidative, anti-inflammatory, anticancer, and other beneficial effects. This review highlights the different bioactivities of flavonoids, chromones, and coumarins and their metal-ions complexes due to different structural characteristics. In addition to insight into the most studied antioxidative properties of these compounds, the first part of the review provides a comprehensive overview of exogenous and endogenous sources of reactive oxygen and nitrogen species, oxidative stress-mediated damages of lipids and proteins, and on protective roles of antioxidant defense systems, including plant-derived antioxidants. Additionally, the review covers the anti-inflammatory and antimicrobial activities of flavonoids, chromones, coumarins and their metal-ion complexes which support its application in medicine, pharmacy, and cosmetology.

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Oligomeric proanthocyanidins attenuate airway inflammation in asthma by inhibiting dendritic cells maturation

Cited by 26 publications

References 39 publications

Association of vitamin�D receptor expression with inflammatory changes and prognosis of asthma

Association of vitamin�D receptor expression with inflammatory changes and prognosis of asthma

Recent Advances on the Anti-inflammatory and Anti-oxidant properties of Red Grape Polyphenols: In Vitro and in Vivo Studies

Overview of the Antioxidant and Anti-Inflammatory Activities of Selected Plant Compounds and Their Metal Ions Complexes

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