Oligonucleotide-Hybridization Fiber-Optic Biosensor Using a Narrow Bandwidth Long Period Grating

Delgado-Pinar, M.; Shi, Quan; Poveda-Wong, Luis; Delgado‐Pinar, Estefanía; Xu, Buli; Zhao, Jianlog; Cruz, J.L.; Andrés, Miguel V.

doi:10.1109/jsen.2017.2723759

Cited by 19 publications

(6 citation statements)

References 19 publications

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“…This approach constitutes nowadays an important innovation area in the state-of-the-art, for both (bio)chemical and physical sensing (Wang and Wolfbeis, 2020;Zhao et al, 2020). A paradigmatic strategy in this context is to inscribe a periodic modulation in the refractive index of the core material of optical fibers or microfibers, thus fabricating special fiber Bragg gratings (FBGs), microfiber Bragg gratings, long period gratings, and tilted fiber Bragg gratings whose optical response is designed to be sensitive to the presence of analytes in the external medium surrounding the optical device (Bekmurzayeva et al, 2018;Cao et al, 2017, Delgado-Pinar et al, 2017Liu et al, 2018;Loyez et al, 2020;Malachovská et al, 2015;Sridevi et al, 2015;Sypabekova et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

BIO bragg gratings on microfibers for label-free biosensing

Juste-Dolz

Delgado-Pinar

Avella-Oliver

et al. 2021

Biosensors and Bioelectronics

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Section: Introductionmentioning

confidence: 99%

BIO bragg gratings on microfibers for label-free biosensing

Juste-Dolz

Delgado-Pinar

Avella-Oliver

et al. 2021

Biosensors and Bioelectronics

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“…The shape of the resonance neither does change significantly, especially its slope at the middle point of the edge: at T = −10 dB, the slopes of the edges are 2.096±0.009, 1.977±0.012 and 1.8881±0.0011 dB/ºC for increasing temperatures, that is, a maximum deviation in the sensitivity below 10% in terms of variation of transmittance. We pay attention to this value (and not only to the wavelength shift) since it determines the sensitivity of the sensor when measuring variations of transmittance to interrogate the device as a refractometer or a biosensor [9,16]. A linear fit is included in the graph as a guideline (average slope: −18.5±0.8 pm/ºC), however it is clear that the data does not fit to a pure linear behavior (R 2 =0.917).…”

Section: Fabrication and Physical Characterizationmentioning

confidence: 99%

“…Different devices have been proposed for this purpose. Among the evanescent-field-based devices we can find long period gratings (LPGs), tilted fiber Bragg gratings (TFBGs) or BIO-Bragg gratings stamped in tapered fibers [7][8][9][10]. Also, surface modes have been exploited for biosensing: optical microfibers can be metallic coated to support surface plasmon resonances [11,12] and whispering gallery modes in microspheres and microbottles have been demonstrated to show really low detection limits [13,14].…”

Section: Introductionmentioning

confidence: 99%

Resonant Couplings in U-Shaped Fibers for Biosensing

Londero¹,

Delgado-Pinar²,

Cuadrado-Laborde

et al. 2023

J. Lightwave Technol.

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U-shaped tight curvatures in optical fibers lead to resonant couplings between the fundamental and higher order modes that are sensible to different parameters, such as strain or temperature, for example. The optical response of the sensor consists on the shift of the resonant wavelength of the coupling. In the case of singlemode fibers, the coupling involves a so-called "cladding mode" and, due to its evanescent field, the curved region will be sensible to changes in the external medium, as well. In this paper, we present the fabrication and characterization of a robust, easy-to-make, U-shaped fiber sensor based on singlemode telecom fiber and its application for biosensing. The resonant nature of the sensing mechanism presents the advantage of large dynamic ranges for RI variations without the ambiguity of other techniques such as interferometry. We studied the performance of the U-shaped fiber sensor for different bending radii, to optimize its sensitivity and detection limit at 1550 nm operation wavelength, as well as the effect of temperature on its response. The shift of the resonant wavelength was measured in detail as a function of the external RI within the range [1.33-1,37]; the detection limit was established in (3.71±0.03)×10 -5 RIU. Furthermore, the device was successfully tested as a proof of concept biosensor, using a system model antigen-antibody (BSA-aBSA.)

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“…However, the fabrication of a reduced bandwidth device of the order of 1nm by using a high numerical aperture single mode fiber (SMF) allowed the improvement of the resolution of the LPGs. In particular, an LOD of 10 nM ssDNA concentration was achieved with nanometric narrowband LPG sensors [26].…”

Section: A Wavelength Based Sensorsmentioning

confidence: 99%

Advances in Fiber Optic DNA-Based Sensors: A Review

et al. 2021

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DNA is becoming increasingly important in the domain of optical fiber sensors, either as a tool for biosensing, or as a target to detect. In this review the main contributions of the last years are presented both in the domain of wavelength and intensity based configurations. This review comprises the use of natural single strand DNA (ssDNA) sequences as receptors for the detection of ssDNA sequences through hybridization, synthetic nucleic acids receptors for detection of complementary ssDNA sequences, and sensors based on natural and synthetic ssDNA receptors used for the detection of non-DNA targets. Parameters such as sensitivity, detection range and limit of detection are analyzed and discussed in detail to the purpose of comparing the different technologies and knowing the future lines to follow in the domain of fiber optic DNA-based sensors.

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Oligonucleotide-Hybridization Fiber-Optic Biosensor Using a Narrow Bandwidth Long Period Grating

Cited by 19 publications

References 19 publications

BIO bragg gratings on microfibers for label-free biosensing

BIO bragg gratings on microfibers for label-free biosensing

Resonant Couplings in U-Shaped Fibers for Biosensing

Advances in Fiber Optic DNA-Based Sensors: A Review

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