Oligonucleotide synthesis. Part 21. Synthesis of ribooligonucleotides using the 4-methoxybenzyl group as a new protecting group for the 2'-hydroxyl group

Advances in the Synthesis of Oligonucleotides by the Phosphoramidite Approach

“…~9 Small oligoribonucleotides (3-9 mers) carrying either the 2'-O-(4-methoxylbenzyl) or the 2'-O-(3,4-dimethoxybenzyl) group were prepared according to the phosphotriester approach. [389][390][391] The (methoxyethoxy)methyl group (MEM) has also been proposed as a 2'-OH protecting group for uridine and has been applied to the synthesis of an uridylate trimer by the phosphotriester method. …”

Effects of Chain Ends on Thermal and Mechanical Properties and Recyclability of Poly(γ‐butyrolactone)

“…Hydroxyl groups are very reactive toward many reagents and can be readily protected by formation of an ether, a silyl ether, or an ester . In this work, by taking advantage of the reactive OH group located at each P γ BL chain end, we first utilized the above reactions to convert P γ BL‐OH chains into P γ BL‐OR by end‐capping with reactive acyl chloride, silyl chloride, or anhydride reagents.…”

Benzophenone-containing cholesterol surrogates

“…According to the procedure of Takaku, Kamaike, and Tsuchiya (19), to a solution of 710 mg (1.76 mmol) of 19, prepared according to the procedure of Rychnovsky and Mickus (20), in 10 ml of dry CH 2 Cl 2 were added 967 mg (3.51 mmol) of 20, mp 109-111ЊC [literature (21), mp 110-112ЊC], prepared according to the procedure of Zhao et al (21), 813 mg (3.51 mmol) of Ag 2 O, and 710 mg of 3Å molecule sieves. After the mixture was heated at 50ЊC for 2 days, the same amounts of 20, Ag 2 O, and 3 Å molecule sieves were added again, and the resulting mixture was heated at 50ЊC for another 5 days.…”