Oligosaccharide concentrations in colostrum, transition milk, and mature milk of primi- and multiparous Holstein cows during the first week of lactation

Fischer-Tlustos, A.J.; Hertogs, K; Niekerk, J.K. van; Nagorske, M.; Haines, Deborah M.; Steele, M.A.

doi:10.3168/jds.2019-17357

Cited by 52 publications

(54 citation statements)

References 45 publications

(90 reference statements)

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“…Moreover, higher concentrations of IgG, LF, α-LA, and β-LG in the digesta of the small intestine were observed in C24h lambs than in M24h lambs, despite the fact that higher α-LA intakes were observed in M24h lambs (Table 2). This result can probably be attributed to the faster degradation of milk proteins than colostrum proteins in the GIT to meet the requirements of host growth and development in lambs because of the low amount of nutritional and bioactive substances in milk compared with colostrum (Fischer-Tlustos et al, 2020). In addition, as discussed earlier, many protease inhibitors present in colostrum protect colostral proteins against proteolytic degradation in the abomasum (Yvon et al, 1993;Quigley et al, 1995;McGrath et al, 2016).…”

Section: Zhu Et Al: Colostral Proteins and Blood Traits In Lambsmentioning

confidence: 95%

Evaluation of colostrum bioactive protein transfer and blood metabolic traits in neonatal lambs in the first 24 hours of life

Zhu

Zhao

Chen

et al. 2021

Journal of Dairy Science

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Colostrum is a unique resource that contributes to the passive transfer of immunity and plays a central role in the health status of neonatal ruminants. However, digestion and absorption of colostral proteins in the gut remain incompletely understood. Therefore, this study aimed to investigate the effect of bovine colostrum feeding on blood metabolic traits and to quantify colostral bioactive proteins in the gastrointestinal digesta and blood to evaluate intestinal transfer in neonatal lambs in the first 24 h of life. Fifty-four newborn lambs were used in this study, including 27 lambs fed pooled bovine colostrum and slaughtered at 6 (C6h), 12 (C12h), or 24 h (C24h) after birth; 18 lambs not fed any colostrum or milk and slaughtered at birth (N0h) or 24 h (N24h) after birth; and 9 milk-fed lambs slaughtered at 24 h (M24h) after birth. Lambs receiving colostrum or milk were bottle-fed within the first 2 h to obtain intakes of 8% of body weight at birth. Samples of blood and digesta from the abomasum, jejunum, and ileum were collected after slaughter. Serum concentrations of glucose, insulin, total protein, and aspartate aminotransferase were higher in colostrum-fed lambs than in N0h lambs. Serum concentrations of insulin, total protein, insulin-like growth factor 1, and γ-glutamyl transpeptidase were higher in C24h lambs than in N24h or M24h lambs. Apparent efficiencies of IgG absorption in C6h, C12h, and C24h lambs were 14.4, 26.8, and 17.2%, respectively, whereas apparent efficiencies of lactoferrin (LF), α-lactalbumin (α-LA), and β-lactoglobulin (β-LG) absorption were very low in colostrum-fed lambs, with mean values of 0.06, 0.002, and 0.003%, respectively. Concentrations of IgG, LF, α-LA, and β-LG in the digesta of the abomasum, jejunum, and ileum rapidly decreased from C6h to C24h lambs, and the disappearance rates of IgG, LF, α-LA, and β-LG were higher in lambs from C6h to C12h (62.1, 75.7, 91.3, and 95.0% for IgG, LF, α-LA, and β-LG, respectively) than from C12h to C24h (34.6, 22.5, 7.5, and 2.2% for IgG, LF, α-LA, and β-LG, respectively). These results indicated that bovine colostrum feeding improved the metabolic and immunological status of lambs, and that ingested colostral IgG was prone to intact uptake into the blood, whereas almost all ingested LF, α-LA, and β-LG disappeared in the lumen of the gastrointestinal tract in a time-dependent manner. The findings provide novel information for exploring selective absorption of colostral compounds in the small intestine of lambs.

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Section: Zhu Et Al: Colostral Proteins and Blood Traits In Lambsmentioning

confidence: 95%

Evaluation of colostrum bioactive protein transfer and blood metabolic traits in neonatal lambs in the first 24 hours of life

Zhu

Zhao

Chen

et al. 2021

Journal of Dairy Science

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“…Overall, the fat content of colostrum is higher than that of transition or mature milk [95]. Elevated concentrations of certain fatty acids in colostrum insinuates that lipids may be essential for neonatal calves [108]. Neonatal ruminants are born with low energy stores and a limited ability to thermoregulate [109], as only 3% of a calf's body weight is made up of lipids at birth [110].…”

Section: Colostrummentioning

confidence: 99%

Section: Colostrummentioning

confidence: 99%

“…Although the concentrations of colostral components can vary, colostrum typically contains less than half the amount of lactose and more than 70% of oligosaccharides found in whole milk [ 101 ]. High levels of sialylated oligosaccharides are beneficial, as they have many potential prophylactic functions [ 101 , 102 ]. During a disease state, oligosaccharides provide several benefits through the inhibition of the binding capacity of certain pathogens, including E. coli and rotavirus, to the intestinal epithelium [ 102 , 103 , 104 , 105 , 106 ] and through the reduction in gut permeability by enhancing the expression of lipoproteins that comprise the tight junctional complexes [ 105 , 106 ].…”

Section: Colostrummentioning

confidence: 99%

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A Narrative Review on the Unexplored Potential of Colostrum as a Preventative Treatment and Therapy for Diarrhea in Neonatal Dairy Calves

Carter

Renaud

Steele

et al. 2021

Animals

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Diarrhea is the leading cause of morbidity and mortality in pre-weaned dairy calves and, as such, represents a significant animal health and welfare concern. Furthermore, digestive disease early in life is associated with several long-term consequences such as reduced growth rate and decreased milk yield during the first lactation, thus generating severe economic losses. The majority of diarrheic cases in young calves are treated with antimicrobials; however, it is necessary to develop alternative treatments, as excessive antimicrobial usage can lead to antimicrobial resistance and can negatively impact the gut microflora of a calf. Bovine colostrum is abundant in immune and bioactive factors that improve immune function and development. This rich and natural combination of immunoglobulins, natural antimicrobial factors, growth factors, anti-inflammatories and nutrients may be an attractive alternative to antimicrobials in the treatment of diarrhea in young dairy calves. There is evidence that supports the use of colostrum as an early treatment for diarrhea in young calves. Future research should investigate its therapeutic and economic effectiveness.

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“…Not only do the milks of mammals exhibit a high diversity of oligosaccharide types (Urashima et al, 2000(Urashima et al, , 2009(Urashima et al, , 2013Messer and Urashima, 2002;Fischer-Tlustos et al, 2020;Weinborn et al, 2020), but they can also be highly polymorphic between individuals within the same species. This is particularly true of humans, in which there are many oligosaccharide types present (Gabrielli et al, 2011;Urashima et al, 2012;ten Bruggencate et al, 2014), which can differ dramatically between individual women (Newburg et al, 2004;Zivkovic et al, 2011).…”

Section: Lactose and Oligosaccharidesmentioning

confidence: 99%

Atlantic Grey Seal Milk Shows Continuous Changes in Key Metabolites and Indicators of Metabolic Transition in Pups From Birth to Weaning

2021

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Mothers of the Atlantic grey seal, Halichoerus grypus, lactate for about 20 days, during which they do not feed and may have no access to water. Following weaning, they depart to sea leaving their pups unattended and unfed for up to another 40 days. We are interested in how this lactation strategy supports the pups’ rapid growth and development while also preparing them for their long fast before independently going to sea. We report a broad spectrum metabolomic analysis of whole milks of these seals that reveals continuous changes in key metabolites from birth to weaning. Certain components exhibit abbreviated appearances at the onset of lactation, followed by continuous rises or falls in others until weaning. Riboflavin/Vitamin B2, hormone-related sterol sulfates, lactose, and complex oligosaccharides all appear in milk briefly after birth then disappear. Lipids associated with cellular signaling and brain development occur at highest levels shortly after birth, then diminish. In contrast, other lipids and Vitamin B6/pyridoxine steadily increase as weaning approaches. Overall, these findings may indicate an early transition from carbohydrate to fat-based energy metabolism and establishment of gut microbiomes in pups, followed by provisioning for post-weaning development and fasting.

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Oligosaccharide concentrations in colostrum, transition milk, and mature milk of primi- and multiparous Holstein cows during the first week of lactation

Cited by 52 publications

References 45 publications

Evaluation of colostrum bioactive protein transfer and blood metabolic traits in neonatal lambs in the first 24 hours of life

Evaluation of colostrum bioactive protein transfer and blood metabolic traits in neonatal lambs in the first 24 hours of life

A Narrative Review on the Unexplored Potential of Colostrum as a Preventative Treatment and Therapy for Diarrhea in Neonatal Dairy Calves

Atlantic Grey Seal Milk Shows Continuous Changes in Key Metabolites and Indicators of Metabolic Transition in Pups From Birth to Weaning

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