Oligosaccharides derived from <i>Lycium barbarum</i> ameliorate glycolipid metabolism and modulate the gut microbiota community and the faecal metabolites in a type 2 diabetes mouse model: metabolomic bioinformatic analysis

Líu, Hao; Zhang, Zheng; Li, Jianpeng; Liu, Wei; Warda, Mohamad; Cui, Bo; El‐Aty, A. M. Abd

doi:10.1039/d1fo02667d

Cited by 17 publications

(12 citation statements)

References 79 publications

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“…The Goji polysaccharides could remarkably promote the growth of Clostridium cluster , F. prausnitzii and and Roseburia spp., thereby notably increasing the content of butyrate and alleviating IL-10 deficient colitis in mice [ 51 ]. Lycium barbarum oligosaccharides promoted the growth of beneficial bacteria, including Akkermansia , Bacteroides , Lactobacillus and Prevotella , and reduced the symptoms of inflammation, insulin resistance and hyperglycemia in the T2D mouse model [ 52 ]. CMPP were fermented to increase acetic acid, propionic acid and butyric acid during the intake period, stimulating the growth of Akkermansia , Bacteroides , Bifidobacterium , Feacalibacterium , and Roseburia .…”

Section: Resultsmentioning

confidence: 99%

Immunological Activity and Gut Microbiota Modulation of Pectin from Kiwano (Cucumis metuliferus) Peels

Zhu

Song

Martínez-Cuesta

et al. 2022

Foods

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For developing the recycling of fruit by-products from kiwano, a polysaccharide was extracted from kiwano (Cucumis metuliferus) peels, namely Cucumis metuliferus peels polysaccharide (CMPP), with the aim of investigating the potential beneficial effects. The composition of polysaccharides was analyzed by chemical methods. RAW264.7 macrophages cells and the microbiota dynamics simulator (BFBL gut model) were used for in vitro study. The result showed that CMPP mainly consists of glucuronic acid, arabinose, galactose and rhamnose. By intervening with RAW264.7 cells, CMPP promoted cell proliferation and showed immune-enhancing activity, which significantly (p < 0.05) induced the release of nitric oxide (NO), tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6) at a concentration of 50 μg/mL. In addition, CMPP had an impact on the composition of the gut bacteria, increasing the growth of Akkermansia, Bacteroides, Bifidobacterium, Feacalibacterium, and Roseburia. During the intake period, acetic, butyric and propionic acids were all increased, especially (p < 0.05) in the descending colon. Moreover, a decrease in ammonia concentration (10.17 ± 0.50 mM in the ascending colon, 13.21 ± 1.54 mM in the transverse colon and 13.62 ± 0.45 mM in the descending colon, respectively) was observed. In summary, CMPP can be considered as a pectin, showed immunological activity and function of gut microbiota modulation. This study could be the scientific basis of developing kiwano peels as beneficial to human health.

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Section: Resultsmentioning

confidence: 99%

Immunological Activity and Gut Microbiota Modulation of Pectin from Kiwano (Cucumis metuliferus) Peels

Zhu

Song

Martínez-Cuesta

et al. 2022

Foods

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“…There is growing evidence indicating that the structural imbalance of the human gut microbiota contributes to the development of T2DM and other metabolic disorders. 16 The gut microbiota is frequently referred to as a "neglected organ". 17 Changes in the gut microbiota have been found to cause T2DM by influencing inflammation, insulin resistance, and aberrant hepatic lipid metabolism.…”

Section: Introductionmentioning

confidence: 99%

Jerusalem artichoke inulin supplementation ameliorates hepatic lipid metabolism in type 2 diabetes mellitus mice by modulating the gut microbiota and fecal metabolome

Jia

Yuan

et al. 2022

Food Funct.

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“…After the protein was removed with the Sevag reagent (CHCl 3 :n-BuOH = 4:1), the solution was dialyzed and lyophilized to obtain LBP. LBO was extracted from LBP by referring to the method of Liu et al [ 11 ]. Pronase E (Solarbio Technology Co., LTD, Beijing, China), H 2 SO 4 , and trifluoroacetic acid (TFA) were used to degrade L. barbarum polysaccharide, which then underwent desalting and concentration to obtain LBO.…”

Section: Methodsmentioning

confidence: 99%

“…A previous study found that the L. barbarum oligosaccharide (LBO) improves type 2 diabetes. Moreover, LBO can alleviate liver injury by restoring the morphology of hepatocytes and improving hepatic steatosis and inflammation [ 11 ]. The oligosaccharides present in L. barbarum may be potential prebiotics that exhibit hypolipidemic activity, such as lowering total cholesterol levels [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Lycium barbarum Oligosaccharides Alleviate Hepatic Steatosis by Modulating Gut Microbiota in C57BL/6J Mice Fed a High-Fat Diet

Zhang

et al. 2023

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High-fat diets (HFD) can promote the development of hepatic steatosis by altering the structure and composition of gut flora. In this study, the potential therapeutic mechanism of Lycium barbarum oligosaccharide (LBO) against hepatic steatosis was investigated by analyzing the changes in the intestinal flora and metabolites in mice. Mice on an HFD were administered LBO by gavage once daily for a continuous period of eight weeks. Compared with the HFD group, the levels of triglyceride (TG), alanine aminotransferase (ALT) in the serum, and hepatic TG were significantly reduced in the LBO group, and liver lipid accumulation was obviously improved. In addition, LBO could regulate the HFD-induced alteration of intestinal flora. The HFD increased the proportion of Barnesiellaceae, Barnesiella, and CHKCI001. LBO increased the proportion of Dubosiella, Eubacterium, and Lactobacillus. LBO also altered the fecal metabolic profile. Significantly different metabolites between LBO and the HFD, such as taurochenodeoxycholate, taurocholate, fluvastatin, and kynurenic acid, were related to the cholesterol metabolism, bile acid metabolism, and tryptophan metabolic pathways. In light of the above, LBO can alleviate HFD-induced NAFLD by modulating the components of the intestinal flora and fecal metabolites.

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Oligosaccharides derived from Lycium barbarum ameliorate glycolipid metabolism and modulate the gut microbiota community and the faecal metabolites in a type 2 diabetes mouse model: metabolomic bioinformatic analysis

Abstract: Herein, we assessed the effects of Lycium barbarum oligosaccharides (LBO) on the intestinal microenvironment of type 2 diabetes (T2D) mouse model through gut microbiome and metabolomics analysis. We set high...

Cited by 17 publications

References 79 publications

Immunological Activity and Gut Microbiota Modulation of Pectin from Kiwano (Cucumis metuliferus) Peels

Immunological Activity and Gut Microbiota Modulation of Pectin from Kiwano (Cucumis metuliferus) Peels

Jerusalem artichoke inulin supplementation ameliorates hepatic lipid metabolism in type 2 diabetes mellitus mice by modulating the gut microbiota and fecal metabolome

Lycium barbarum Oligosaccharides Alleviate Hepatic Steatosis by Modulating Gut Microbiota in C57BL/6J Mice Fed a High-Fat Diet

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