Olive oil, fruit and leaves in diabetes mellitus type 2 treatment

Nosić, Mario; Waisundara, Viduranga Y; Banjari, Ines

doi:10.37349/eff.2023.00015

Cited by 2 publications

(1 citation statement)

References 106 publications

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“…Because of this, the Mediterranean countries possessed lower rates of colorectal cancer occurrence in comparison with Western countries (Go et al ., 2003). Metabolomic analysis of these foods has confirmed various unique compounds that have direct or indirect links with eating patterns and human health (Hill et al ., 2022; Nosić et al ., 2023).…”

Section: Application Of Omic Technique In Studying the Effect Of Nutr...mentioning

confidence: 99%

Foodomics: futuristic omic strategies to assess the impact of food nutrients on human health and gut microbiome

Singh,

Barthwal,

Negi

et al. 2024

Int J of Food Sci Tech

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SummaryFoodomics is an omic technique that integrates with the study of food and nutrition. The technique delves into the composition, functions, and expression outcomes of genomics, transcriptomics, proteomics, and metabolomics, shedding light on how nutrients influence gene and protein expression. It enables the understanding of cellular processes, functional mechanisms, and molecules involved and identifies targets for bioactive compounds desirable for nutritional intervention strategies. It also facilitates the discovery of biomarkers that elucidate the bioactivities of various food components, offering insights into their implications for individual well‐being. Furthermore, due to the molecular interplay between food and gut microbiome, this technique offered a comprehensive understanding of nutritional dynamics and the role of nutrients in maintaining optimal health. Hence, the article highlights the recent research that deciphers the bioactive activities of various food components, shedding insight on their consequences for individual well‐being and intricating the balance of the gut microbiota using this omic technique.

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Section: Application Of Omic Technique In Studying the Effect Of Nutr...mentioning

confidence: 99%

Foodomics: futuristic omic strategies to assess the impact of food nutrients on human health and gut microbiome

Singh,

Barthwal,

Negi

et al. 2024

Int J of Food Sci Tech

View full text Add to dashboard Cite

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Potential synergistic antihyperglycemic effects of co-supplemental Amla and Olive extracts in hyperlipidemic adults with prediabetes and type 2 diabetes: results from a real-life clinical study

Michel P.,

Ahn,

Rousseau

et al. 2024

Front. Nutr.

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BackgroundHyperglycemia and type 2 diabetes mellitus (T2DM) pose a significant risk for cardiovascular diseases and associated complications in individuals with hyperlipidemia. Statin therapy, effective in reducing cholesterol and cardiovascular risks, paradoxically increases incident T2DM risk due to its adverse impact on glucose homeostasis. Therefore, there is a pressing need for safe, and effective adjunctive or alternative therapies to manage hyperglycemia in hyperlipidemic individuals. There is growing body of pharmacological evidence suggesting that Amla and Olive extract supplementation can be beneficial in managing hyperglycemia in individuals with hyperlipidemia.ObjectiveThe present study aimed to assess for the first time the potential synergistic antihyperglycemic effects of a daily co-supplementation of 1,000 mg Amla fruit and 50 mg Olive fruit standardized extracts (Cholesfytol NG®) over a 2-months period in hyperlipidemic adults with T2DM or prediabetes.MethodsThis retrospective cross-sectional observational study analyzed treatment outcomes in 191 hyperlipidemic adults under the care of their physicians at 57 General Practitioner clinics in Belgium during real-life clinical practice between March 19, 2020, and January 31, 2022. These participants received Cholesfytol NG® as supplementary therapy to improve their metabolic health. The supplement was prescribed in an open-label, non-randomized manner, tailored to each participant’s need.ResultsAfter 2-months of Cholesfytol NG® supplementation, participants showed significant reductions in glycemia levels: in the T2DM group, levels decreased by 42.7 ± 17.9 mg/dL (27.9%, p < 0.0001), and in the prediabetic group, by 2.26 ± 11.5 mg/dL (4.7%, p = 0.0020). Conversely, no significant change was observed in participants with normal baseline glycemia (1.55 ± 10.3 mg/dL, p = 0.088). Overall, glycemia levels decreased from 96.4 ± 18.2 mg/dL to 94.0 ± 13.5 mg/dL (mean decrease of 2.4 ± 14.5 mg/dL, p < 0.0001). The supplement was well tolerated and no side-effects, serious adverse events, or treatment-emergent effects were reported.ConclusionThe findings of this real-life clinical study highlight the potential synergistic antihyperglycemic effects of co-supplementation with Amla and Olive fruit extracts in managing hyperglycemia, particularly in individuals with hyperlipidemia. These results suggest that this botanical combination may help mitigate risks associated with hyperglycemia and cardiovascular disease in hyperlipidemic population.Clinical trial registrationClinicalTrials.gov, NCT06187298.

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Olive oil, fruit and leaves in diabetes mellitus type 2 treatment

Cited by 2 publications

References 106 publications

Foodomics: futuristic omic strategies to assess the impact of food nutrients on human health and gut microbiome

Foodomics: futuristic omic strategies to assess the impact of food nutrients on human health and gut microbiome

Potential synergistic antihyperglycemic effects of co-supplemental Amla and Olive extracts in hyperlipidemic adults with prediabetes and type 2 diabetes: results from a real-life clinical study

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