Olive oil improves the intestinal absorption and bioavailability of lutein in lutein-deficient mice

Nidhi, Bhatiwada; Mamatha, Bangera Sheshappa; Baskaran, Vallikanan

doi:10.1007/s00394-013-0507-9

Cited by 36 publications

(14 citation statements)

References 28 publications

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“…37 It has been shown that monounsaturated fatty acids (MUFA), such as olive oils, increase the intestinal uptake of lutein, whereas PUFA-rich fats reduce the uptake of lutein. 34,38,39 Previous studies have related serum lipid levels to the MP density in the retina; a recent study showed that oxidized lowdensity lipoprotein (LDL) was negatively correlated with MPOD, suggesting that increase in oxidized LDL could reduce MPOD. 40 Likewise, it has been reported that high-density lipoprotein (HDL) is the preferential carrier of the MP carotenoids in plasma.…”

Section: Discussionmentioning

confidence: 99%

“…There is evidence that the nature of fatty acids can directly affect intestinal lutein absorption. [34][35][36] Some lipids, such as phosphatidylcholine, have been suggested to strongly retain the hydrophobic lutein in the mixed micelles, thereby suppressing its intestinal uptake. 37 It has been shown that monounsaturated fatty acids (MUFA), such as olive oils, increase the intestinal uptake of lutein, whereas PUFA-rich fats reduce the uptake of lutein.…”

Section: Discussionmentioning

confidence: 99%

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Oral Lutein Supplementation Enhances Macular Pigment Density and Contrast Sensitivity but Not in Combination With Polyunsaturated Fatty Acids

Wolf

Zinkernagel

Munk

et al. 2015

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. It has been shown that lutein and zeaxanthin accumulate in the macula where they enhance contrast sensitivity and may reduce the risk of progression to advanced age-related macular degeneration (AMD). Furthermore, omega-3 long-chain polyunsaturated fatty acids (PUFA) might further reduce this risk. However, controversy exists regarding whether PUFA may reduce the bioavailability of lutein.METHODS. This was a prospective 12-month, randomized, open label study evaluating the effect of supplementation with lutein, other antioxidants, and minerals on contrast sensitivity (CS) and macular pigment optical density (MPOD) in patients with age-related maculopathy. A total of 79 patients were randomized to either lutein (10 mg) and antioxidant supplement or lutein and antioxidant supplement in combination with PUFA. Patients received supplementation for a period of 6 months and were followed for a total of 12 months.RESULTS. Serum lutein and zeaxanthin increased significantly by the first follow-up visit at 1 month, and remained elevated throughout the intervention period of 6 months in the luteinonly group but not in the luteinþPUFA group. Macular pigment optical density and CS increased significantly in the lutein-only group (P < 0.005) but not in the luteinþPUFA group (P ¼ 0.059) compared to baseline. Best-corrected visual acuity remained unchanged during the entire study period in both groups.CONCLUSIONS. Addition of PUFA may reduce the bioavailability of lutein and therefore lessen the beneficial effect on macular pigment and CS. This needs to be considered when prescribing lutein supplements to patients with low lutein levels. (ClinicalTrials.gov number, NCT00563979.)

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Oral Lutein Supplementation Enhances Macular Pigment Density and Contrast Sensitivity but Not in Combination With Polyunsaturated Fatty Acids

Wolf

Zinkernagel

Munk

et al. 2015

Invest. Ophthalmol. Vis. Sci.

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“…Nutrient absorption is known to be assisted by the intake of fats and oils. Olive oil has been shown to improve the lutein absorption and its bioavailability in mice with a lutein-deficiency through modification of the activity of intestinal triacylglycerol lipase [75]. Conversely, the literature shows that butter and palm oil with highly saturated fats enhanced the bioavailability of xanthophylls compared with the high PUFA oils [76].…”

Section: Absorption and Bioavailability Of Nutrients And Antioxidantsmentioning

confidence: 99%

Nutrients for Prevention of Macular Degeneration and Eye-Related Diseases

Khoo

Yap

et al. 2019

Antioxidants

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The risk of macular degeneration can be reduced through the consumption of antioxidant-rich foods, supplements, and nutraceutical formulas. This review focuses on the antioxidants, vitamins, and minerals that have been reported for reducing the risk of macular degeneration and other eye-related diseases. Antioxidants including anthocyanins, carotenoids, flavonoids, and vitamins have been shown to reduce the risk of eye-related diseases. Anthocyanins extracted from berries are powerful antioxidants. Cyanidin, delphinidin, malvidin, pelargonidin, peonidin, and petunidin are anthocyanin aglycones detected in berries, currants, and other colored fruits and vegetables. β-Carotene, as well as xanthophyll lutein and zeaxanthin, have been reported to reduce the risk of macular degeneration. Flavonoids from plants help in the prevention of eye-related diseases through anti-inflammatory mechanisms. A combination of these antioxidants, vitamins, and minerals possess a synergistic effect on the prevention or risk reduction of macular degeneration. Formulas have been developed as dietary supplements to cater to the high demand from consumers and patients with eye problems. Many of the formulated dietary supplements that are sold in the market have been clinically proven for their efficacy to treat eye diseases. Although the bioactivities in the supplement capsules or tablets have been scientifically established for reducing risks of several diseases, which include macular degeneration and other eye-related diseases, knowledge on the right dosage, efficacy, and bioavailability of antioxidants, vitamins, and minerals is important for consumers. The information may help them make the best decision in choosing the right dietary supplements and nutraceuticals following the evidence-based recommended dosages and reference intakes for improving general health and preventing eye-related diseases. This review covers the potential causal factors involved in eye diseases, clinically proven treatments, and controversial findings on the antioxidants in the prevention of macular degeneration. Future studies should consider multiethnic and multicenter trials for eliminating potential bias in research.

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“…The micronization process used here helps the formulation to reduce particle size and improve the dissolution rate, which in turn helps to enhance oral bioavailability [ 33 , 34 ]. We also used multiple functional oils as a part of the formulation, which is known to improve absorption in the gut [ 35 , 36 , 37 ]. BAC has been used successfully to develop in vivo dry eye disease models in mice and rabbits through topical applications into the eye [ 38 , 39 , 40 ].…”

Section: Discussionmentioning

confidence: 99%

A Novel Integrated Active Herbal Formulation Ameliorates Dry Eye Syndrome by Inhibiting Inflammation and Oxidative Stress and Enhancing Glycosylated Phosphoproteins in Rats

et al. 2020

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Dry eye syndrome (DES) is a chronic condition of the eye with insufficient production of tears leading to inadequate lubrication of eyes. Symptoms of DES are associated with discomfort and redness of the eye, blurred vision, and tear film instability which leads to the damaged ocular surface. Inflammation and oxidative stress play a significant role in the pathogenesis of the disease. In this study, the protective effect of different doses (100 or 200 mg/kg) of a novel multi-component oral formulation of lutein/zeaxanthin, curcumin, and vitamin D3 (LCD) was evaluated using a rat model with benzalkonium chloride (BAC)-induced dry eye syndrome. The formulation was administered orally to rats for 4 weeks. We observed a significant improvement in tear volume, tear breakup time, tear film integrity, and reduction in overall inflammation in rats fed with the LCD at dose 200 mg/kg performing better than 100 mg/kg. Furthermore, the formulation helped in lowering oxidative stress by increasing antioxidant levels and restored protective tear protein levels including MUC1, MUC4, and MUC5AC with 200 mg of LCD having the most significant effect. The results strongly suggest that the combination of lutein/zeaxanthin, curcumin, and vitamin-D3 is effective in alleviating the symptoms of dry eye condition with a multi-modal mechanism of action.

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Olive oil improves the intestinal absorption and bioavailability of lutein in lutein-deficient mice

Abstract: Dietary olive oil rich in oleic acid improves the bioavailability and accumulation of lutein in lutein-deficient mice by modifying the intestinal triacylglycerol lipase activity.

Cited by 36 publications

References 28 publications

Oral Lutein Supplementation Enhances Macular Pigment Density and Contrast Sensitivity but Not in Combination With Polyunsaturated Fatty Acids

Oral Lutein Supplementation Enhances Macular Pigment Density and Contrast Sensitivity but Not in Combination With Polyunsaturated Fatty Acids

Nutrients for Prevention of Macular Degeneration and Eye-Related Diseases

A Novel Integrated Active Herbal Formulation Ameliorates Dry Eye Syndrome by Inhibiting Inflammation and Oxidative Stress and Enhancing Glycosylated Phosphoproteins in Rats

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