Oral Lutein Supplementation Enhances Macular Pigment Density and Contrast Sensitivity but Not in Combination With Polyunsaturated Fatty Acids

Wolf, Sebastian; Zinkernagel, Martin S.; Munk, Marion R.; Ebneter, Andreas; Wolf, Sebastián

doi:10.1167/iovs.15-17586

Cited by 42 publications

(29 citation statements)

References 38 publications

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“…Previous work has shown that MPOD is important for optimal visual performance and may protect against AMD because of the antioxidant effect of lutein and zeaxanthin [33][34][35][36]. The present study demonstrates that consumption of 12 eggs per week for a period of 1 year signifi cantly raises serum zeaxanthin concentrations and reduces glare recovery time and may improve, but not signifi cantly, serum lutein concentrations and MPOD in patients diagnosed with early AMD.…”

Section: Discussionsupporting

confidence: 51%

Consumption of 12 Eggs per Week for 1 Year Significantly Raises Serum Zeaxanthin Levels and Improves Glare Recovery in Patients with Early Age-Related Macular Degeneration

A.¹

2017

J Clin Res Ophthalmol

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Age-related macular degeneration (AMD) is the number one form of blindness in older adults due to the degeneration of the macula of the eye. Lutein and zeaxanthin are carotenoids that accumulate in the macula and may help protect it from short-wavelength light damage. The dietary sources of these carotenoids are green leafy, yellow vegetables; and eggs. The aim of this study was to determine if the consumption of 12 store-bought eggs per week for 1 year slows down the progression of AMD. Forty-fi ve adults were randomized to the intervention (n=27) or control (n=18). A clinical eye exam was performed at 0 and 12 months. Results showed greater increases in serum lutein (52% vs. 6%) and zeaxanthin (83% vs. 0%) in the intervention compared to control from baseline to 12 months, however only serum zeaxanthin increased signifi cantly. The right eye macular pigment optical density (MPOD) increased more in the intervention (5.6% vs. 1.9%), while left eye MPOD increased more in the control (20.0% vs. 14.3%). However, the mean percent change in MPOD within subjects was increased more in the intervention for the right (37% vs 14%) and left (42% vs 39%) eye when compared to control, but not signifi cantly. The intervention demonstrated signifi cantly greater improvement in the left eye (86%) when compared to the control and a respective 32% decrease from baseline for glare recovery measurements. In conclusion, consuming 12 eggs per week for 1 year signifi cantly raises serum zeaxanthin concentrations and may improve glare recovery in patients with early AMD.

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Section: Discussionsupporting

confidence: 51%

Consumption of 12 Eggs per Week for 1 Year Significantly Raises Serum Zeaxanthin Levels and Improves Glare Recovery in Patients with Early Age-Related Macular Degeneration

A.¹

2017

J Clin Res Ophthalmol

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“…Resveratrol is well-absorbed, but its bioavailability is low [45]. Cells were treated at concentrations ranging from 0 to 27.17 µM for curcumin, 0 to 70 µM for lutein [46], and 0 to 43.9 µM for resveratrol [47].…”

Section: Discussionmentioning

confidence: 99%

Cytoprotective Effects of Natural Highly Bio-Available Vegetable Derivatives on Human-Derived Retinal Cells

et al. 2020

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Retinal pigment epithelial cells are crucial for retina maintenance, making their cytoprotection an excellent way to prevent or slow down retinal degeneration. In addition, oxidative stress, inflammation, apoptosis, neovascularization, and/or autophagy are key pathways involved in degenerative mechanisms. Therefore, here we studied the effects of curcumin, lutein, and/or resveratrol on human retinal pigment epithelial cells (ARPE-19). Cells were incubated with individual or combined agent(s) before induction of (a) H2O2-induced oxidative stress, (b) staurosporin-induced apoptosis, (c) CoCl2-induced hypoxia, or (d) a LED-autophagy perturbator. Metabolic activity, cellular survival, caspase 3/7 activity (casp3/7), cell morphology, VEGF levels, and autophagy process were assessed. H2O2 provoked a reduction in cell survival, whereas curcumin reduced metabolic activity which was not associated with cell death. Cell death induced by H2O2 was significantly reduced after pre-treatment with curcumin and lutein, but not resveratrol. Staurosporin increased caspase-3/7 activity (689%) and decreased cell survival by 32%. Curcumin or lutein protected cells from death induced by staurosporin. Curcumin, lutein, and resveratrol were ineffective on the increase of caspase 3/7 induced by staurosporin. Pre-treatment with curcumin or lutein prevented LED-induced blockage of autophagy flux. Basal-VEGF release was significantly reduced by lutein. Therefore, lutein and curcumin showed beneficial protective effects on human-derived retinal cells against several insults.

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“…In addition, lutein and zeaxanthin supplementation can improve visual performance in glares [ 24 ]. MP can also increase contrast sensitivity [ 25 , 26 ]. Both of these issues are major problem in POAG patients.…”

Section: Discussionmentioning

confidence: 99%

Macular Pigment Optical Density in Chinese Primary Open Angle Glaucoma Using the One-Wavelength Reflectometry Method

Chen

Lin

et al. 2016

Journal of Ophthalmology

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Purpose. To investigate macular pigment optical density (MPOD) and its relationship with retinal thickness in primary open angle glaucoma (POAG) patients using the one-wavelength reflectometry method. Methods. A total of 30 eyes from 30 POAG patients (18 males and 12 females, mean age 47.27 ± 16.93) and 52 eyes from 52 controls (27 males and 25 females, mean age 49.54 ± 19.15) were included in this prospective, observational, case-control study. MPOD was measured in a 7-degree area using one-wavelength reflectometry method. Two parameters, max and mean optical density (OD), were used for analyses. Spectral-domain-optical coherence tomography was used to measure retinal thickness, including central retinal thickness (CRT), the macular ganglion cell complex (GCC), and the circumpapillary retinal nerve fiber layer (RNFL). Results. Both maxOD and meanOD were significantly reduced in POAG patients compared with normal subjects (P < 0.001). GCC, CRT, and RNFL thicknesses were also significantly reduced in POAG patients (P < 0.001). GCC thickness had a positive relationship with MPOD. Conclusions. MPOD within the 7-degree area was significantly lower in Chinese POAG patients than in control subjects, and GCC thickness was significantly and positively associated with MPOD. Whether the observed lower MPOD in POAG contributes to the disease process or is secondary to pathological changes caused by the disease (such as loss of ganglion cells) warrants further and longitudinal study.

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Oral Lutein Supplementation Enhances Macular Pigment Density and Contrast Sensitivity but Not in Combination With Polyunsaturated Fatty Acids

Cited by 42 publications

References 38 publications

Consumption of 12 Eggs per Week for 1 Year Significantly Raises Serum Zeaxanthin Levels and Improves Glare Recovery in Patients with Early Age-Related Macular Degeneration

Consumption of 12 Eggs per Week for 1 Year Significantly Raises Serum Zeaxanthin Levels and Improves Glare Recovery in Patients with Early Age-Related Macular Degeneration

Cytoprotective Effects of Natural Highly Bio-Available Vegetable Derivatives on Human-Derived Retinal Cells

Macular Pigment Optical Density in Chinese Primary Open Angle Glaucoma Using the One-Wavelength Reflectometry Method

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