Olive polyphenol hydroxytyrosol prevents bone loss

Hagiwara, Kenta; Goto, Tadashi; Araki, Masahiro; Miyazaki, Hitoshi; Hagiwara, Hiromi

doi:10.1016/j.ejphar.2011.04.023

Cited by 116 publications

(106 citation statements)

References 28 publications

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“…Furthermore, a dose-response protective effect of oleuropain, an olive oil polyphenol, has been found on bone mass in an experimental in vivo model of bone loss in rats [34]. Accordingly, [35] concluded that olive polyphenols, particularly hydroxytyrosol, prevented bone loss in ovariectomized mice, and suggested olive polyphenols may provide insights into the development of tools useful in preventing and treating osteoporosis.…”

Section: Discussionmentioning

confidence: 99%

Effect of Feeding on Olive Oil and Thyme on Pregnancy and Lactation Periods

Salem¹

2015

IJNFS

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Abstract:This study aimed to evaluate the effect of feeding on virgin olive oil (VOO) and extra virgin olive oil (EVOO) at 50% and 100% with or without thyme leaves at 1% and 2.5% on pregnancy and lactation periods. Methods: One hundred and twenty adult female rats (120 ±5g) were randomly divided into 15 groups (n=8) for month before mating. On 19 th day of pregnancy, half of pregnant rats were weighted, killed and their fetuses take off with uterus. Another half of pregnant rats were left to evaluate the lactation period. Biochemical assays, bone measurements and fertility hormones were evaluated. Results: Generally, the VOO groups were improved the health status of pregnant and lactating rats more than EVOO groups. The pregnant rats in VOO and thyme leaves powder groups were lower of body weight gain (BWG) without their fetuses than EVOO and thyme leaves powder groups. The mean weight of fetuses in VOO and thyme leaves powder groups were higher than EVOO combined with thyme leaves groups. Also, the feeding on olive oils with thyme leaves had an increase of number of fetuses and bone Ca and P contents. The results showed that, in an increasing of number of fetuses caused decrease in bone mineral density (BMD). Pregnant and lactating rats fed on 100% olive oils had TC, TG, LDL-C, and VLDL-C lower than the rats fed on 50% olive oils. Also, the rats fed on olive oils and thyme leaves powder had increase in both E2 and progesterone levels before mating and at the end of lactation period compared to control group. Meanwhile, the prolactin hormone levels for rats at the end of lactation period were lower than on 19 th day of pregnancy period. Conclusion: Diet which containing with olive oil improved the health status, especially during pregnancy and lactation periods. Consumption of olive oil and olive oil and thyme leaves could be reduce the risk of infertility in females.

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Section: Discussionmentioning

confidence: 99%

Effect of Feeding on Olive Oil and Thyme on Pregnancy and Lactation Periods

Salem¹

2015

IJNFS

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“…Puel et al (2008) ont étudié le potentiel ostéoprotecteur de ces métabolites (tyrosol, hydroxytyrosol), in vivo et démon-tré leur efficacité. Il en est de même pour les travaux publiés par Hagiwara et al (2011) qui confirment l'effet préventif de l'oleuropéine et de l'hydroxytyrosol, au niveau trabéculaire, chez la souris ovariectomisée.…”

Section: Cas Des Polyphénols De L'huile D'oliveunclassified

“…Ceci s'explique notamment par une réduction des dommages oxydatifs et des taux plasmatiques en cytokines pro-inflammatoires. Hagiwara et al (2011) ont testé l'oleuropéine, l'hydroxytyrosol et le tyrosol sur les cellules osseuses in vitro. Aucun de ces composés ne stimule la prolifération de MC3T3-E1 (lignée ostéoblastique), y compris à des concentrations allant jusqu'à 10 µM.…”

Section: Cas Des Polyphénols De L'huile D'oliveunclassified

Huile d’olive et santé osseuse

Coxam

Wauquier

Darie

et al. 2014

OCL

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Résumé -L'ostéoporose représente un problème majeur de santé. La prise en charge classique de cette pathologie, essentiellement curative, est destinée aux personnes qui ont exprimé la maladie. Une telle stratégie ciblant la personne âgée souffrant d'ostéoporose sévère s'avère trop tardive. En fait, le traitement idéal de l'ostéoporose, pour être efficace, doit être oral, dénué d'effet secondaire, et surtout précoce de façon à inhiber très en amont le processus de perte osseuse. C'est pourquoi les stratégies de prévention visant à réduire les risques d'ostéoporose doivent être développées et instaurées. Ainsi, le concept d'une alimentation saine, fournissant des quantités suffisantes de différents nutriments potentiellement ostéoprotecteurs, mérite d'être mentionné. Dans cette optique, les olives ou l'huile d'olive vierge sont des aliments fonctionnels intéressants qui, en plus de leur richesse en acides gras mono-insaturés (acide oléique), contiennent plusieurs composants polyphénoliques ayant des propriétés biologiques spécifiques. Ils pourraient ainsi constituer des éléments efficaces pour prévenir l'ostéoporose, comme en témoignent les données de la littérature. Mots clés :Huile d'olive / polyphénols / acides gras / santé osseuse Abstract -Olive oil and bone health. Osteoporosis represents a major healthcare burden. Current pharmacologic approaches to osteoporosis are directed at those who already have the disease, which is often too late for the aged person with severe osteoporosis. Actually, the ideal therapy for to be effective for osteoporosis prevention needs to be oral, to be safe, and to inhibit bone loss as early as possible. This is why broad-based preventive strategies designed to lower the risks of osteoporosis need to be established and implemented. Thus, the concept of a healthy diet providing adequate amounts of various potent micronutrients deserves mention. In this light, olives or virgin olive oil are functional foods which besides having a high level of MUFA, the oleic acid, contains multiple minor phenolic components with specific biological properties. They could thus be a key component of successful dietary manipulations to prevent osteoporosis, as shown by many scientific publications.

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“…24,25 Olive oil polyphenols such as oleuropein and hydroxytyrosol can stimulate the deposition of calcium in osteoblastic MC3T3-E1 cells. 26 Despite the useful property of natural polyphenols to enhance bone formation, a major drawback is that they are rapidly metabolized and excreted from the body, making controlled release at the site of bone loss an important goal.…”

Section: Introductionmentioning

confidence: 99%

Powering tyrosol antioxidant capacity and osteogenic activity by biocatalytic polymerization

et al. 2016

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Oxidative polymerization of tyrosol by horseradish peroxidase (HRP)-H 2 O 2 afforded an insoluble product (oligotyrosol, OligoTyr) consisting of mixture of linear oligomers (up to 11-mer) with limited benzylic branching points, as evidenced by ESI-MS and solid state 13 C NMR analysis. OligoTyr proved to be significantly more active than tyrosol in several antioxidant assays and was not toxic to human osteosarcoma SaOS-2 cells, stimulating alkaline phosphatase (ALP) activity at day 7 in a similar manner as tyrosol. However, when loaded at 5% w/w into highly porous polylactic acid (PLA) scaffolds featuring hierarchical structures, OligoTyr caused a significant increase in the ALP activity of SaOS-2 cells compared to PLA alone, while tyrosol was completely inactive. A release of ca. 5% from PLA was determined after 1 week in a physiological medium. No significant influence on calcium release from PLA scaffolds containing 5% b-tricalcium phosphate was observed.

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Olive polyphenol hydroxytyrosol prevents bone loss

Cited by 116 publications

References 28 publications

Effect of Feeding on Olive Oil and Thyme on Pregnancy and Lactation Periods

Effect of Feeding on Olive Oil and Thyme on Pregnancy and Lactation Periods

Huile d’olive et santé osseuse

Powering tyrosol antioxidant capacity and osteogenic activity by biocatalytic polymerization

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