Omalizumab in the Treatment of Chronic Urticaria

Francés, Laura Soto; Leiva-Salinas, Maria; Silvestre, J.F.

doi:10.1016/j.adengl.2013.06.003

Cited by 8 publications

(5 citation statements)

References 48 publications

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“…Our review is intended to provide a comprehensive, critical, and rigorous synthesis of this body of evidence and to provide an informed opinion on the use of omalizumab across the diverse patient phenotypes affected by CIU/CSU. As a systematic review, it extends and updates the clinical and product reviews and summaries on omalizumab in CIU/CSU published to date [27][28][29][30][31][32][33][34][35][36], and provides guidance to clinicians.…”

Section: Introductionmentioning

confidence: 90%

Effectiveness of omalizumab in adolescent and adult patients with chronic idiopathic/spontaneous urticaria: a systematic review of ‘real-world’ evidence

Bernstein

Kavati

Tharp

et al. 2018

Expert Opinion on Biological Therapy

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Chronic idiopathic/spontaneous urticaria (CIU/CSU) is a dermatological condition characterized by itchy wheals and/or angioedema of continuous or intermittent duration of ≥6 weeks with a high burden of disease and impact on quality of life. Omalizumab is a recombinant humanized monoclonal antibody that inhibits the binding of IgE to high affinity receptors, and is approved for the CIU/CSU indication. The objective of this systematic review was to evaluate and synthesize the evidence on the real-world effectiveness of omalizumab in CIU/CSU in daily clinical practice. Areas covered: This review of 84 observational effectiveness studies covers treatments (dosing, medication use), clinical outcomes (treatment response, disease activity, quality of life), and safety. Expert opinion: The clinical outcomes observed across studies underscore the real-world effectiveness of omalizumab in the management of CIU/CSU. Continued treatment may assist patients showing an initial response to achieve a complete treatment response. Response rates are aligned with observed changes in disease activity, symptom experience, and quality of life, and this across subtypes of CIU/CSU. The positive therapeutic profile is complemented by a positive safety profile. The real-world evidence summarized here points convincingly at the high degree of effectiveness of omalizumab in the treatment of CIU/CSU in daily clinical practice.

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Section: Introductionmentioning

confidence: 90%

Effectiveness of omalizumab in adolescent and adult patients with chronic idiopathic/spontaneous urticaria: a systematic review of ‘real-world’ evidence

Bernstein

Kavati

Tharp

et al. 2018

Expert Opinion on Biological Therapy

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“…The special attention that the treatment of CSU with omalizumab is drawing recently materialized in several recent reviews dedicated to it [38][39][40][41][42]. Part of this interest derives from the theoretical assumptions about its mechanisms of action in urticaria and angioedema, which seem to differ from those underlying the effect of this biologic agent in asthma [11].…”

Section: Success Rates Of Omalizumab Treatmentmentioning

confidence: 99%

Biologic agents and the therapy of chronic spontaneous urticaria

Kaplan

Popov²

2014

Current Opinion in Allergy &Amp; Clinical Immunology

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“…Omalizumab appears to be a safe and well-tolerated drug. The most common side effects observed with omalizumab are the injection site reactions (40%) (pain, swelling, erythema, and itching) and urticaria (4.9%) 15 . Anaphylaxis has been reported in 0.09% of patients with allergic asthma.…”

Section: Introductionmentioning

confidence: 99%

Omalizumab in chronic urticaria: A comprehensive review

Kocatürk¹,

Kızıltaç²,

Leslie³

2018

TURKDERM

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Humanize monoklonal anti-immunoglobulin E antikoru olan omalizumab ilk kez alerjik solunum yolu hastalıklarının tedavisi için geliştirilmiş olup 2014 yılında antihistamin dirençli kronik spontan ürtiker tedavisi için onay almıştır. Henüz indüklenebilir ürtikerin tedavisinde onaylanmamış olmasına rağmen tüm kronik ürtiker (KÜ) alt tiplerinde başarılı bir şekilde uygulanmaktadır. Klinik çalışmalarda ve gerçek yaşam verilerinde bildirilen hafif yan etkiler güvenli bir ilaç olduğunu düşündürmektedir. KÜ'deki kullanımına ait cevaplanmamış sorular kullanım süresi, tedavinin nasıl kesileceği ve uzun dönem yan etkileridir. Bu derlemede bu sorulara ilişkin cevaplar verilmeye çalışılmaktadır. Anahtar Kelimeler: Omalizumab, kronik ürtiker, fiziksel ürtiker, tedaviOmalizumab is a humanized monoclonal anti-immunoglobulin E which is originally developed for the treatment of allergic respiratory disorders, but has been approved for the treatment of antihistamine-resistant chronic spontaneous urticaria in 2014. It has become a game changer in the treatment of all subtypes of chronic urticaria (CU) even though it has not been yet approved for inducible urticarias. It is a safe drug with minor adverse events reported in the clinical trials as well as real life studies. The main questions that remain to be answered regarding its use for CU are the duration of treatment, how to cease the treatment and safety of long-term use. Available information about these questions are tried to be provided in this review. AbstractOmalizumab acts by preventing the binding of IgE to the high-affinity receptors (FcεRI) on mast cells and basophils 4 . Its efficacy has been demonstrated in antihistamine-resistant CSU patients by case reports, case series, observational studies, and randomized placebo-controlled studies [5][6][7][8][9][10][11] . It is the only approved add-on treatment for CSU patients aged 12 years or older who do not respond to H1 antihistamines in both Europe and the US 12 . The efficacy of omalizumab has not only been demonstrated in autoimmune urticaria, but also in the physical, cholinergic, and other forms of urticaria 13 . It has been approved for the treatment of antihistamine-resistant CSU/chronic idiopathic urticaria (CIU)

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Omalizumab in the Treatment of Chronic Urticaria

Cited by 8 publications

References 48 publications

Effectiveness of omalizumab in adolescent and adult patients with chronic idiopathic/spontaneous urticaria: a systematic review of ‘real-world’ evidence

Effectiveness of omalizumab in adolescent and adult patients with chronic idiopathic/spontaneous urticaria: a systematic review of ‘real-world’ evidence

Biologic agents and the therapy of chronic spontaneous urticaria

Omalizumab in chronic urticaria: A comprehensive review

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