Omega-3 Fatty Acid Based Nanolipid Formulation of Atorvastatin for Treating Hyperlipidemia

Sreedhar, Revathy; Kumar, Vrinda S.; Pillai, Anil Kumar Bhaskaran; Sabitha, M.

doi:10.15171/apb.2019.031

Cited by 23 publications

(10 citation statements)

References 38 publications

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“…The accelerated stability study was carried out to determine the shelf life of the CO-NLCs [ 28 ]. The samples were kept in tightly sealed glass bottles and stored at two different temperatures and ambient humidity conditions (30 °C/60% and 40 °C/75%) for a period of 3 months.…”

Section: Methodsmentioning

confidence: 99%

Clove Oil-Nanostructured Lipid Carriers: A Platform of Herbal Anesthetics in Whiteleg Shrimp (Penaeus vannamei)

Kaewmalun

Yata

Kitiyodom

et al. 2022

Foods

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Whiteleg shrimp (Penaeus vannamei) have been vulnerable to the stress induced by different aquaculture operations such as capture, handling, and transportation. In this study, we developed a novel clove oil-nanostructured lipid carrier (CO-NLC) to enhance the water-soluble capability and improve its anesthetic potential in whiteleg shrimp. The physicochemical characteristics, stability, and drug release capacity were assessed in vitro. The anesthetic effect and biodistribution were fully investigated in the shrimp body as well as the acute multiple-dose toxicity study. The average particle size, polydispersity index, and zeta potential value of the CO-NLCs were 175 nm, 0.12, and −48.37 mV, respectively, with a spherical shape that was stable for up to 3 months of storage. The average encapsulation efficiency of the CO-NLCs was 88.55%. In addition, the CO-NLCs were able to release 20% of eugenol after 2 h, which was lower than the standard (STD)-CO. The CO-NLC at 50 ppm observed the lowest anesthesia (2.2 min), the fastest recovery time (3.3 min), and the most rapid clearance (30 min) in shrimp body biodistribution. The results suggest that the CO-NLC could be a potent alternative nanodelivery platform for increasing the anesthetic activity of clove oil in whiteleg shrimp (P. vannamei).

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Section: Methodsmentioning

confidence: 99%

Clove Oil-Nanostructured Lipid Carriers: A Platform of Herbal Anesthetics in Whiteleg Shrimp (Penaeus vannamei)

Kaewmalun

Yata

Kitiyodom

et al. 2022

Foods

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“…Melt-Emulsification combined with Ultrasonica tion Method was recently reported (Sreedhar et al, 2019). Fig.…”

Section: Methods Of Preparationmentioning

confidence: 99%

Lipid Nanostructured Particles as Emerging Carriers for Targeted Delivery of Bioactive Molecules: Applications in Food and Biomedical Sciences (An Overview)

Muntean¹,

Socaciu²,

Socaciu³

2020

BUASVMCN-FST

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Lipid nanoparticles are getting a growing scientific and technological interest, worldwide. Either Solid Lipid Nanoparticles (SLNs), Nanostructured Lipid Carriers (NLCs), Lipid Drug Conjugates (LDCs) or Polymer-Lipid Nanoparticles (PLNs) have been produced and investigated last years, being reccomended as emerging carrier systems for many food and biomedical applications. An overview of the last publications, mainly since 2017 is presented, underlying the most important methods and techniques used for their preparation (e.g. high shear homogenization in hot and cold conditions, ultrasound assisted melt emulsification) as well techniques applied for measuring the size, calorimetric properties, zeta-potential, etc. Most relevant data related to the use of food-grade ingredients and designed lipid nanoparticles as delivery systems for organic and inorganic bioactive molecules in food or packaging’s are presented. The major reason for this trend in food science is the aim to overcome problems associated with the low bioavailability of many lipophilic bioactive compounds which are claimed to bring benefits to human health (carotenoid or anthocyanin pigments, sterols, vitamins). Finally, the recent applications of different formulas of lipid nanoparticles as drug carriers for in vitro experiments or for in vivo therapy (oral, parenteral or transdermal formulas) are presented.

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“…Another study conducted by a separate group in 2019 focused on utilizing Atorvastatin (Caplin Point Laboratories Ltd., Pondicherry, India) nano lipid carriers preloaded with ω-3-PUFA (Triomega, Sanofi India Ltd., Mumbai, India) to lower hyperlipidemia. When compared with the commercial formulation, orally administered ω-3-FA based AT preloaded nano lipid carriers resulted in a substantial decrease in low-density lipoprotein and triglyceride levels in the blood [106]. Through various studies, nanoencapsulation has been shown to increase the bioavailability of ω-3-PUFAs in the body.…”

Section: Nano-encapsulation Of Omega-3 Pufamentioning

confidence: 99%

Revolutionizing Cardiovascular Health with Nano-Encapsulated Omega-3 Fatty Acids: A Nano-Solution Approach

Gill,

Al-Badr,

Al-Ghouti

et al. 2024

Preprint

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Omega-3 polyunsaturated fatty acids (ɷ-3 PUFAs) offer diverse health benefits, such as supporting cardiovascular health, improving cognitive function, promoting joint and musculoskeletal health, and contributing to healthy aging. Despite their advantages, challenges like oxidation susceptibility, low bioavailability, and potential adverse effects at high doses persist. Nanoparticle encapsulation emerges as a promising avenue to address these limitations while preserving stability, enhanced bioavailability, and controlled release. This comprehensive review explores the therapeutic roles of omega-3 fatty acids, critically appraising their shortcomings and delving into modern encapsulation strategies. Furthermore, it explores the potential advantages of Metal-organic framework nanoparticles (MOF NPs) compared to other commonly utilized nanoparticles in improving the therapeutic effectiveness of omega-3 fatty acids within drug delivery systems (DDS). Additionally, it outlines future research directions to fully exploit the therapeutic benefits of these encapsulated omega-3 formulations for cardiovascular disease treatment.

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Omega-3 Fatty Acid Based Nanolipid Formulation of Atorvastatin for Treating Hyperlipidemia

Cited by 23 publications

References 38 publications

Clove Oil-Nanostructured Lipid Carriers: A Platform of Herbal Anesthetics in Whiteleg Shrimp (Penaeus vannamei)

Clove Oil-Nanostructured Lipid Carriers: A Platform of Herbal Anesthetics in Whiteleg Shrimp (Penaeus vannamei)

Lipid Nanostructured Particles as Emerging Carriers for Targeted Delivery of Bioactive Molecules: Applications in Food and Biomedical Sciences (An Overview)

Revolutionizing Cardiovascular Health with Nano-Encapsulated Omega-3 Fatty Acids: A Nano-Solution Approach

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