Omega‐3 fatty acids and liver disease†‡

Lee, Sang; Gura, Kathleen M.; Puder, Mark

doi:10.1002/hep.21645

Cited by 59 publications

(48 citation statements)

References 45 publications

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“…3A). The increase in the ratio of TG to HDL-C is known to increase the risk of atherosclerosis, 34) and that was observed as 1.0 from normal and 1.8 from glucose-treated rats. Because the increase of MTP activity results in elevation of VLDL secretion, it is nature that the levels of TG, cholesterol, and apoB containing in VLDL would be increased in blood or hepatocyte culture medium.…”

Section: Discussionmentioning

confidence: 98%

Augmentation of Ca2+-Induced Microsomal Triglyceride Transfer Protein Activity by Glucose Supply Enhances Hypertriglyceridemia in Vivo

Cho

Kang

et al. 2006

Biological & Pharmaceutical Bulletin

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We have investigated possible roles of intra-glucose supply on microsomal triglyceride (TG) transfer protein (MTP) in the secretion of TG-rich very low-density lipoprotein (VLDL) from the liver. Due to the activation of MTP, TG and apolipoprotein B (apoB) in the liver are assembled into VLDL and then the VLDL is transferred into the blood stream. High MTP activity can increase the release of VLDL into the blood stream, and this would lead high levels of TG and apoB in the blood. High MTP activity was found when the liver (or hepatocytes) contained a high level of total Ca 2؉ as a response of glucose administration. However, the MTP activity was reduced in response to the calmodulin antagonist N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide (W-7, K i ‫52؍‬ m mM), the intracellular Ca 2؉ chelator BAPTA-AM, and the extracellular Ca 2؉ chelator EDTA. These suggested that there might be a very close relationship between high MTP activity and high Ca 2؉ level in the liver by glucose administration. Glucose-derived hyperglycemic condition resulted from those elevations of TG and total cholesterol in the liver. This hyperglycemic phenomenon may be associated with the increase of TG and apoB levels in blood. The possibility for the regulation of VLDL formation in the liver and, further, those related circulatory diseases due to the excess of VLDL in the blood stream by controlling MTP activity in association with Ca 2؉ was investigated.

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Section: Discussionmentioning

confidence: 98%

Augmentation of Ca2+-Induced Microsomal Triglyceride Transfer Protein Activity by Glucose Supply Enhances Hypertriglyceridemia in Vivo

Cho

Kang

et al. 2006

Biological & Pharmaceutical Bulletin

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“…Активація процесів ПОЛ має причинно-наслідкові зв'язки із структурно-функціональною цілісністю мембранних структур і зумовлює їх модифікації, в першу чергу, за рахунок окислення поліненасичених жирних кислот (ПНЖК), що призводить до загибелі клітин ПЗ [6,7].…”

Section: на експериментальній моделі гострого панкреатиту (гп) в щуріunclassified

“…Відомо, що рівень насиченості жирних кислот (ЖК) регулюється складними системами ензимів, серед яких ключова роль належить десатуразам, які каталізують утворення подвійних зв'язків у молекулах довголанцюгових ЖК [9]. За дани-ми літератури відомо, що активність десату-еКСПеРимеНтАЛьНі РОбОти раз, у тому числі Δ6-десатурази, залежить від багатьох факторів [7]. Кількість подвійних зв'язків у ланцюзі визначають температуру фазового переходу, фізико-хімічні властивості мембранних фосфоліпідів, а також плинність біологічних мембран [9].…”

Section: на експериментальній моделі гострого панкреатиту (гп) в щуріunclassified

“…тому зміна вмісту та співвідношення жирних кислот можуть порушувати регуляцію біохімічних процесів у клітині та призводити до патологічного стану. Крім того, зміна складу ліпідів впливає на фізико-хімічні властивості плазматичних мембран, що значною мірою визначає особливості адаптивної відповіді клітин на дію чинників внутрішнього та зовнішнього середовищ [7,9].…”

Section: на експериментальній моделі гострого панкреатиту (гп) в щуріunclassified

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Oxidative stress in blood leukocytes, pro/antioxidanт status and fatty acids composition of pancreas lipids at experimental acute pancreatitis in rats

Pryvrotska¹,

Kuchmerovska²

2013

Ukr.Biochem.J.

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“…40 Fish oil may have other benefits, such as anti-inflammatory and/or antiproliferative properties and might improve hepatic steatosis, but more studies are needed in this immunosuppressed transplant population. 41 It should be noted that fish oil may increase the low-density lipoprotein level, so a follow-up lipid panel should be performed.…”

Section: Dyslipidemiamentioning

confidence: 99%

Long-term Medical Management of the Liver Transplant Recipient: What the Primary Care Physician Needs to Know

Singh

Watt

2012

Mayo Clinic Proceedings

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Recognition, management, and prevention of medical complications and comorbidities after liver transplant is the key to improved long-term outcomes. Beyond allograft-related complications, metabolic syndrome, cardiovascular disease, renal dysfunction, and malignancies are leading causes of morbidity and mortality in this patient population. Primary care physicians have an important role in improving outcomes of liver transplant recipients and are increasingly relied on for managing these complex patients. This review serves to assist the primary care physician in the long-term management issues of liver transplant recipients.

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Omega‐3 fatty acids and liver disease†‡

Cited by 59 publications

References 45 publications

Augmentation of Ca2+-Induced Microsomal Triglyceride Transfer Protein Activity by Glucose Supply Enhances Hypertriglyceridemia in Vivo

Augmentation of Ca2+-Induced Microsomal Triglyceride Transfer Protein Activity by Glucose Supply Enhances Hypertriglyceridemia in Vivo

Oxidative stress in blood leukocytes, pro/antioxidanт status and fatty acids composition of pancreas lipids at experimental acute pancreatitis in rats

Long-term Medical Management of the Liver Transplant Recipient: What the Primary Care Physician Needs to Know

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