Omega 3 fatty acids can reduce early doxorubicin‐induced cardiotoxicity in children with acute lymphoblastic leukemia

Amrousy, Doaa El; El-Afify, Dalia; Khedr, Rasha; Ibrahim, Ahmed

doi:10.1002/pbc.29496

Cited by 17 publications

(21 citation statements)

References 45 publications

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“…Two studies ( 91 , 92 ) were RCTs using DOX as the chemotherapy agent, and the other two studies ( 93 , 94 ) were non-randomized controlled trials using anthracyclines. The covered dietary nutrients contained PUFA [ n = 2, derived from omega 3 fatty acids ( 91 ) and black seed oil ( 92 )] and CoQ10 ( n = 2) ( 93 , 94 ). The characteristics of the included human studies are summarized in Table 2 .…”

Section: Resultsmentioning

confidence: 99%

“…The overall risk of bias of included human studies was at moderate to high risk. All items of Cochrane risk of bias tool were rated as low risk in one RCT ( 91 ), and three items (blinding of participants and personnel, blinding of outcome assessment, and selective outcome reporting) were rated as unclear risk in another RCT ( 92 ). The NOS's scores of the non-randomized trials were 5( 93 ) and 6 ( 94 ) respectively, due to the lack of blind evaluation, follow-up and loss to follow up, and the inadequate reports of confounders adjustment.…”

Section: Resultsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

“…Four human studies were conducted in Egypt [in 2021 (91) and 2020 (92)], Italy [in 1994 (93)] and the USA [in 1978 (94)]. Three studies (91)(92)(93) recruited pediatric patients diagnosed with acute lymphoblastic leukemia (ALL) aged 1 to 16 years and one (94) recruited adults with bronchogenic carcinoma. Two studies (91,92) were RCTs using DOX as the chemotherapy agent, and the other two studies (93,94) were non-randomized controlled trials using anthracyclines.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Three studies (91)(92)(93) recruited pediatric patients diagnosed with acute lymphoblastic leukemia (ALL) aged 1 to 16 years and one (94) recruited adults with bronchogenic carcinoma. Two studies (91,92) were RCTs using DOX as the chemotherapy agent, and the other two studies (93,94) were non-randomized controlled trials using anthracyclines. The covered dietary nutrients contained PUFA [n = 2, derived from omega 3 fatty acids (91) and black seed oil (92)] and CoQ10 (n = 2) (93,94).…”

Section: Study Characteristicsmentioning

confidence: 99%

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Can Dietary Nutrients Prevent Cancer Chemotherapy-Induced Cardiotoxicity? An Evidence Mapping of Human Studies and Animal Models

Zhang

Yang²,

Li³

et al. 2022

Front. Cardiovasc. Med.

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IntroductionChemotherapy has significantly improved cancer survival rates at the cost of irreversible and frequent cardiovascular toxicity. As the main dose-dependent adverse effect, cardiotoxic effects not only limit the usage of chemotherapeutic agents, but also cause the high risk of severe poor prognoses for cancer survivors. Therefore, it is of great significance to seek more effective cardioprotective strategies. Some nutrients have been reported to diminish cardiac oxidative damage associated with chemotherapy. However, the currently available evidence is unclear, which requires a rigorous summary. As such, we conducted a systematic review of all available evidence and demonstrated whether nutrients derived from food could prevent cardiotoxicity caused by chemotherapy.MethodsWe searched Medline (via PubMed), Embase and the Cochrane Library from inception to Nov 9, 2021 to identify studies reporting dietary nutrients against cancer chemotherapy-related cardiotoxicity. We performed descriptive summaries on the included studies, and used forest plots to demonstrate the effects of various dietary nutrients.ResultsFifty-seven eligible studies were identified, involving 53 animal studies carried on rats or mice and four human studies in cancer patients. Seven types of dietary nutrients were recognized including polyphenols (mainly extracted from grapes, grape seeds, and tea), allicin (mainly extracted form garlic), lycopene (mainly extracted from tomatoes), polyunsaturated fatty acids, amino acids (mainly referring to glutamine), coenzyme Q10, and trace elements (mainly referring to zinc and selenium). Dietary nutrients ameliorated left ventricular dysfunctions and myocardial oxidative stress at varying degrees, which were caused by chemotherapy. The overall risk of bias of included studies was at moderate to high risk.ConclusionThe results indicated that dietary nutrients might be a potential strategy to protect cardiovascular system exposed to the chemotherapeutic agents, but more human studies are urged in this field.Systematic Review Registration:https://inplasy.com/inplasy-2022-3-0015/.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

See 3 more Smart Citations

Can Dietary Nutrients Prevent Cancer Chemotherapy-Induced Cardiotoxicity? An Evidence Mapping of Human Studies and Animal Models

Zhang

Yang²,

Li³

et al. 2022

Front. Cardiovasc. Med.

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Omega‐3 supplementation attenuates doxorubicin‐induced cardiotoxicity but is not related to the ceramide pathway

Monte,

Tonon,

Fujimori

et al. 2024

Food Science & Nutrition

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Cardiotoxicity is the serious side effect of doxorubicin treatment. Ceramides are formed from the degradation of sphingolipids in cell membranes and play an important role in signaling and modulating biological processes. There is evidence that omega‐3 fatty acid administration can act on this pathway. To evaluate the role of the ceramide pathway in the pathophysiology of doxorubicin‐induced cardiotoxicity and the effect of omega‐3 fatty acid supplementation in the attenuation of chronic doxorubicin‐induced cardiotoxicity in rats. Sixty male Wistar rats were divided into four groups: Control (C), Doxorubicin (D), Omega‐3 fatty acids (W), and Doxorubicin + Omega‐3 fatty acids (DW). The groups received omega‐3 fatty acids (400 mg/kg/day, via gavage) or water for 6 weeks and doxorubicin (3.5 mg/kg, intraperitoneal) or saline once a week for 4 weeks. Doxorubicin‐treated animals showed increases in left atrium and left ventricle diameters, serum triglycerides and cholesterol, malondialdehyde, and protein carbonylation. We also observed a decrease in left ventricular shortening fraction and nSMase1 expression in the heart. Omega‐3 fatty acid supplementation attenuated the structural and functional alterations caused by doxorubicin and decreased protein carbonylation. In contrast to doxorubicin, omega‐3 fatty acids increased neutral nSMase activity in animals that both received and did not receive doxorubicin but with no effect on nSMase1 protein expression. Omega‐3 fatty acid supplementation attenuated the cardiotoxicity caused by doxorubicin. The ceramide pathway may be involved in the pathophysiology of cardiotoxicity, but it is not the mechanism by which omega‐3 fatty acids attenuated cardiac dysfunction.

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Myocardial function using two dimension speckle-tracking echocardiography in children with celiac disease

El Amrousy,

Elshehaby,

Elsharaby

et al. 2023

Eur J Pediatr

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The prevalence of cardiac complications linked to celiac disease (CD) is on expanding. This study aimed to evaluate the cardiac function in children with CD using two dimensional speckle tracking echocardiography (2D-STE) to detect early myocardial dysfunction, if any. This cross-sectional study included 40 children with CD as the patient group and 40 healthy age- and sex-matched children served as the control group. High sensitive troponin T (Hs-troponin T), anti-tissue transglutaminase immunoglobulin A (tTG-IgA), hemoglobin, ferritin, albumin, and vitamin D levels were measured in all participants. Conventional, tissue Doppler imaging (TDI), and 2D-STE were performed for all included children. Conventional echocardiographic parameters showed no significant difference between the two groups. Left ventricular global longitudinal strain (LV GLS) obtained by 2D-STE was substantially lower in children with CD than the control group; however, myocardial performance index (MPI) obtained by TDI was significantly higher in children with CD. Hs-troponin T levels were comparable in both groups. LV GLS was positively correlated with hemoglobin, ferritin, and albumin level, but it was inversely correlated with the duration of the disease and anti tTG-IgA. Conclusion: 2D-STE can detect subclinical early cardiac dysfunction in children with CD and this cardiac injury correlated to the duration and severity of the disease and some nutritional deficiency in these children. What is Known:• The prevalence of cardiac complications linked to celiac disease (CD) is on expanding.• Only one study evaluated cardiac function in children with CD using two dimensional speckle tracking echocardiography (2D-STE). What is New:• Our study found that 2D-STE can detect early subclinical cardiac dysfunction in children with CD. Cardiac injury in theses children correlated to the duration and severity of the disease, hemglobin, ferritin, and albumin levels.

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Omega 3 fatty acids can reduce early doxorubicin‐induced cardiotoxicity in children with acute lymphoblastic leukemia

Cited by 17 publications

References 45 publications

Can Dietary Nutrients Prevent Cancer Chemotherapy-Induced Cardiotoxicity? An Evidence Mapping of Human Studies and Animal Models

Can Dietary Nutrients Prevent Cancer Chemotherapy-Induced Cardiotoxicity? An Evidence Mapping of Human Studies and Animal Models

Omega‐3 supplementation attenuates doxorubicin‐induced cardiotoxicity but is not related to the ceramide pathway

Myocardial function using two dimension speckle-tracking echocardiography in children with celiac disease

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