Omega-3 fatty acids improve psychomotor performance via mechanism not related to nitric acid production

Abstract

Omega-3 fatty acids (ω-3FAs) are essential polyunsaturated fats that protect the brain from cognitive impairment. It increases the activity of endothelial nitric oxide synthetase (eNOS) and thereby increases the nitric acid (NO) production. This study aimed to explore the effect of ω-3FAs on psychomotor performance and to relate this effect to the reactive nitrogen species. This study was conducted in . Twenty healthy subjects, allocated randomly from medical college students, were participated in the single blind clinical trial. Participants were divided into two groups, each of ten subjects to receive either placebo or (ω-3FAs) (750 mg single oral dose daily for 5 days). They were asked to perform psychomotor performance before and after 5 days of treatment, and venous blood was obtained for determination of serum nitric oxide (NO) and peroxynitrite (ONOO). ω-3FAs treated group was significantly different from placebo-treated group in reducing choice and motor reaction times as well as the critical flicker frequency threshold. The serum levels of NO and ONOO in ω-3FAs-treated group did not significantly differ from placebo-treated group. Short term supplementation of ω-3FAs improves the psychomotor performance in young healthy subjects via a mechanism not related to the production of nitric oxide production. Inflorescence is a panicle few flowered and fruit is a capsule. The data of the results obtained were presented and discussed.

Neurobehavioural Changes and not Structural Changes Occur in Rat Fed with Cassava Products (Fufu, Garri and Tapioca Diet)

“…Similar observation was reported by Hermer-Vaquez et al [15]; Al-Kuraishy et al [16]; Al-Kuraishy et al [17]. Animals fed on low protein diet usually stopped growing, lose weight, and sometimes adapt to the diet at a slow rate [18,19,20,21]. Our study agreed with this statement because cassava is low in protein and we observed weight drop in the rats fed with cassava only during our experiment.…”

Mixed storm in SARS‐CoV‐2 infection: A narrative review and new term in the Covid‐19 era

“… 77 , 78 , 79 Remarkably, oxylipins derived from omega‐6 fatty acids are more proinflammatory than those derived from omega‐3 fatty acids and are involved in vasoconstriction and proliferation. 80 , 81 Omega‐3 fatty acids derived from oxylipins have antiinflammatory and vasodilatory effects. During inflammation higher expression of COX and LO‐5 trigger the production and release of oxylipins.…”

“…Oxylipins have anti‐inflammatory and/or proinflammatory effects in different diseases including fatty liver disease, atherosclerosis and Alzheimer's disease 77–79 . Remarkably, oxylipins derived from omega‐6 fatty acids are more proinflammatory than those derived from omega‐3 fatty acids and are involved in vasoconstriction and proliferation 80,81 . Omega‐3 fatty acids derived from oxylipins have antiinflammatory and vasodilatory effects.…”