Omega-3 fatty acids in cause, prevention and management of violence in schizophrenia: Conceptualization and application

Ouyang, Wen‐Chen; Sun, Gwo‐Ching; Hsu, Mei‐Chi

doi:10.1016/j.avb.2019.101347

Cited by 7 publications

(9 citation statements)

References 236 publications

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“…In the brain, PUFAs are largely esterified to the phospholipid cell membranes of neurons, glial cells and endothelial cells (Nadjar et al, 2016). As reviewed by (Ouyang et al, 2020) PUFAs account for 35% of total lipids in adult brain. Arachidonic acid (an omega-6 fatty acid) and DHA, which make up 50% and 40% of brain PUFAs, respectively, are important to brain development and maintenance of the brain structure and function.…”

Section: Hypothalamusmentioning

confidence: 99%

Role of bioactive lipids in obesity

Salsinha¹,

Rodriguez‐Alcalá²,

Pimentel³

et al. 2023

Bioactive Lipids

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Section: Hypothalamusmentioning

confidence: 99%

Role of bioactive lipids in obesity

Salsinha¹,

Rodriguez‐Alcalá²,

Pimentel³

et al. 2023

Bioactive Lipids

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“…In the brain, the most abundantly found organic compounds are polyunsaturated fatty acids, which are further classified into ω-6 and ω-3 polyunsaturated fatty acids, derived from linoleic acid and α-linolenic acid, respectively [162,163]. While they were generally ignored for more than 40 years, polyunsaturated fatty acids are essential for normal brain development and function [162][163][164][165][166]. ω-3 fatty acids play fundamentally important biological roles, including neurotransmission, signal transduction, receptor binding, and eicosanoid synthesis, and aid in synaptic plasticity and neuroprotection [165,166].…”

Section: Marine Lipids and Glycolipids For Neuroprotectionmentioning

confidence: 99%

“…While they were generally ignored for more than 40 years, polyunsaturated fatty acids are essential for normal brain development and function [162][163][164][165][166]. ω-3 fatty acids play fundamentally important biological roles, including neurotransmission, signal transduction, receptor binding, and eicosanoid synthesis, and aid in synaptic plasticity and neuroprotection [165,166]. A lack of ω-3 fatty acids has been linked to a chronic pro-inflammatory state in the brain that further leads to dementia and an increased risk of cerebral ischemia [167].…”

Section: Marine Lipids and Glycolipids For Neuroprotectionmentioning

confidence: 99%

Marine Biocompounds for Neuroprotection—A Review

2020

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While terrestrial organisms are the primary source of natural products, recent years have witnessed a considerable shift towards marine-sourced biocompounds. They have achieved a great scientific interest due to the plethora of compounds with structural and chemical properties generally not found in terrestrial products, exhibiting significant bioactivity ten times higher than terrestrial-sourced molecules. In addition to the antioxidant, anti-thrombotic, anti-coagulant, anti-inflammatory, anti-proliferative, anti-hypertensive, anti-diabetic, and cardio-protection properties, marine-sourced biocompounds have been investigated for their neuroprotective potential. Thus, this review aims to describe the recent findings regarding the neuroprotective effects of the significant marine-sourced biocompounds.

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“…The rate of aggressive behavior among them is also 4 to 6 times higher than the general population [ 8 , 9 ]. Repetitive violence is often a multifactorial construct that involves biological, psychosocial, emotional, and pathophysiological factors and contextual, environmental, family-oriented, and situational features, alone or in combination [ 10 , 11 , 12 , 13 , 14 ]. Disorder-specific determinants, such as psychotic symptoms, are not always the sole factor involved in violence [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Integrated Moral Reasoning Development Intervention for Management of Violence in Schizophrenia: A Randomized Controlled Trial

Hsu

Ouyang

2022

JCM

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Moral cognition is an important and multidimensional, but often overlooked, determinant of violence. Very few interventions have systematically examined the role of moral reasoning, anger management and problem-solving together in violence. A randomized controlled trial was conducted to comprehensively evaluate the sustained effects of an integrated Moral Reasoning Development Intervention (MRDI) in the management of repetitive violence in schizophrenia. This study placed special emphasis on essential components related to moral reasoning and violence in patients with schizophrenia. Evaluations, including measures of violence, moral reasoning, ethical valuation and judgement, decision-making, conflict management style, and personality traits, were performed at baseline, end of intervention, and 1-month follow-up after intervention. We found that MRDI was superior to treatment-as-usual, in improving moral reasoning and related variables and violence outcomes (p < 0.05). In comparison with the treatment-as-usual group (n = 22), patients in the MRDI group (n = 21) showed improved levels of moral reasoning, with decreased levels of violent behaviors. The MRDI participants also experienced significantly greater improvements or changes (p < 0.05) in their ethical valuation and judgement, decision-making style and preferences, and conflict management style. Our findings provide important implications for risk assessment and violence management and prevention.

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Omega-3 fatty acids in cause, prevention and management of violence in schizophrenia: Conceptualization and application

Cited by 7 publications

References 236 publications

Role of bioactive lipids in obesity

Role of bioactive lipids in obesity

Marine Biocompounds for Neuroprotection—A Review

Effects of Integrated Moral Reasoning Development Intervention for Management of Violence in Schizophrenia: A Randomized Controlled Trial

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