Omega-3 fatty acids, membrane remodeling and cancer prevention

Fuentes, Natividad R.; Kim, Eun-Joo; Yang, Fan; Chapkin, Robert S.

doi:10.1016/j.mam.2018.04.001

Cited by 64 publications

(35 citation statements)

References 251 publications

(261 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Linoleic acid (LA), as a "matrix" of PUFAs, finally converts into the 20-carbon product-arachidonic acid (AA) through a series of oxidative desaturation and elongation reactions. AA-derived eicosanoids (PGs, TXs, and LTs) are demonstrated to affect tumor development by altering tumor microenvironment in many types of cancer [49][50][51][52][53][54] . FADS1, as the rate-limiting enzyme of PUFA synthesis, catalyzing DGLA to AA, was reported to be frequently dysregulated in cancers.…”

Section: Discussionmentioning

confidence: 99%

FADS1 promotes the progression of laryngeal squamous cell carcinoma through activating AKT/mTOR signaling

et al. 2020

View full text Add to dashboard Cite

Metabolic abnormality is the major feature of laryngeal squamous cell carcinoma (LSCC), however, the underlying mechanism remain largely elusive. Fatty acid desaturase 1 (FADS1), as the key rate-limiting enzyme of polyunsaturated fatty acids (PUFAs), catalyzes dihomo-gamma-linolenic acid (DGLA) to arachidonic acid (AA). In this study, we reported that the expression of FADS1 was upregulated in LSCC, high FADS1 expression was closely associated with the advanced clinical features and poor prognosis of the recurrent LSCC patients after chemotherapy. Liquid chromatograph-mass spectrometry (LC-MS) analysis revealed that FADS1 overexpression induced greater conversion of DGLA to AA, suggesting an increased activity of FADS1. Similarly, the level of prostaglandin E2 (PGE 2), a downstream metabolite of AA, was also elevated in cancerous laryngeal tissues. Functional assays showed that FADS1 knockdown suppressed the proliferation, migration and invasion of LSCC cells, while FADS1 overexpression had the opposite effects. Bioinformatic analysis based on microarray data found that FADS1 could activate AKT/mTOR signaling. This hypothesis was further validated by both in vivo and in vitro assays. Hence, our data has supported the viewpoint that FADS1 is a potential promoter in LSCC progression, and has laid the foundation for further functional research on the PUFA dietary supplementation interventions targeting FADS1/AKT/mTOR pathway for LSCC prevention and treatment.

show abstract

Section: Discussionmentioning

confidence: 99%

FADS1 promotes the progression of laryngeal squamous cell carcinoma through activating AKT/mTOR signaling

et al. 2020

View full text Add to dashboard Cite

show abstract

“…3c). We also believe that this ability to modulate plasma membrane biophysical properties may underlie the chemoprotective effects of other bioactives, such as cathecins and procyanidins [25, 313]. …”

Section: Cancer Chemoprevention By Membrane-targeted Dietary Bioactivesmentioning

confidence: 99%

Functional link between plasma membrane spatiotemporal dynamics, cancer biology, and dietary membrane-altering agents

Erazo-Oliveras

Fuentes

Wright

et al. 2018

Cancer Metastasis Rev

Self Cite

View full text Add to dashboard Cite

The cell plasma membrane serves as a nexus integrating extra- and intracellular components, which together enable many of the fundamental cellular signaling processes that sustain life. In order to perform this key function, plasma membrane components assemble into well-defined domains exhibiting distinct biochemical and biophysical properties that modulate various signaling events. Dysregulation of these highly dynamic membrane domains can promote oncogenic signaling. Recently, it has been demonstrated that select membrane-targeted dietary bioactives (MTDBs) have the ability to remodel plasma membrane domains and subsequently reduce cancer risk. In this review, we focus on the importance of plasma membrane domain structural and signaling functionalities as well as how loss of membrane homeostasis can drive aberrant signaling. Additionally, we discuss the intricacies associated with the investigation of these membrane domain features and their associations with cancer biology. Lastly, we describe the current literature focusing on MTDBs, including mechanisms of chemoprevention and therapeutics in order to establish a functional link between these membrane-altering biomolecules, tuning of plasma membrane hierarchal organization, and their implications in cancer prevention.

show abstract

“… 24 , 25 Multiple genes within the pathway of fatty acid metabolism could influence cancer initiation and progression. 26 – 28 …”

Section: Discussionmentioning

confidence: 99%

<p>Identification of FADS1 Through Common Gene Expression Profiles for Predicting Survival in Patients with Bladder Cancer</p>

Jiao¹,

Sun²,

Yang³

et al. 2020

CMAR

View full text Add to dashboard Cite

Purpose Aim of this study was to identify biomarkers between different grades of bladder cancer (BLCA) and its prognostic value. Methods mRNA expression data from GSE32549 and GSE71576 were extracted for further analysis. Differentially expressed genes (DEGs) were identified using GEO2R web tool. Gene ontology (GO) analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis and protein–protein interaction (PPI) network were conducted to explore the function and relationship of DEGs. The Cancer Genome Atlas (TCGA) database was used for external validation and Gene set enrichment analysis (GSEA) analysis was used to further identify FADS1 pathways. Bladder cancer cells and patient specimens were used to further demonstrate the function of FADS1. Results Datasets from GEO identified a panel of DEGs. Functional enrichment analysis highlighted that DEGs were associated with nuclear division, spindle, cell cycle and p53 signaling pathway. External validation from TCGA demonstrated that FADS1 was an independent prognostic marker in BLCA patients. In cell lines and tumor specimen analysis, FADS1 was overexpressed in the tumor specimen, compared with adjacent tissues, and positively correlated with tumor grade of BLCA. Moreover, FADS1 could enhance the proliferation ability and influence cell cycle of bladder cancer cells. Conclusion FADS1 was an independent prognostic biomarker for BLCA and could confer the bladder cancer cells increased proliferation ability.

show abstract

Omega-3 fatty acids, membrane remodeling and cancer prevention

Cited by 64 publications

References 251 publications

FADS1 promotes the progression of laryngeal squamous cell carcinoma through activating AKT/mTOR signaling

FADS1 promotes the progression of laryngeal squamous cell carcinoma through activating AKT/mTOR signaling

Functional link between plasma membrane spatiotemporal dynamics, cancer biology, and dietary membrane-altering agents

<p>Identification of FADS1 Through Common Gene Expression Profiles for Predicting Survival in Patients with Bladder Cancer</p>

Contact Info

Product

Resources

About