Omega 3 polyunsaturated fatty acids and healthy ageing

Abstract

Fresh evidence provides clues to healthier, not just longer lives

The change and correlates of healthy ageing among Chinese older adults: findings from the China health and retirement longitudinal study

“…Existing studies in China also showed that education is the most important predictor for the improvement in cognitive health of Chinese [ 16 , 27 ]. Moreover, our findings were in accordance with these existing studies on obesity, health-related behaviors and healthy ageing/longevity, confirming that smoking and overweight were detrimental to healthy ageing [ 16 , 33 – 37 ].…”

The phytochemical epigallocatechin gallate prolongs the lifespan by improving lipid metabolism, reducing inflammation and oxidative stress in high‐fat diet‐fed obese rats

“…EGCG significantly decreased the SFA levels in obese rats induced by a high‐fat diet. In addition, EGCG also significantly increased the levels of n‐3 fatty acids and decreased the ratio of n‐6/n‐3 fatty acids, which verified the function of inhibiting inflammation, reducing LDL and TG in serum and the risk of cardiovascular disease, delaying senescence and prolonging lifespan (Lai et al, 2018; Zhu, Ferrara, & Forman, 2018). In addition, EGCG increased the level of α‐linolenic acid and competitively inhibited γ‐linolenic acid, which also plays a key role in improving free fatty acid metabolism or extending the lifespan.…”

Age-associated changes in circulatory fatty acids: new insights on adults and long-lived individuals

“…in the age at death, which corresponds to a gradual increase in human longevity [5]. From 2015 to 2050, the percentage of the worldwide population aged over 60 years is estimated to double from 12 to 22% [6]. At the same time, increasing age is also the leading risk factor for major chronic diseases, such as cardiovascular diseases (CVD) and neurodegenerative disorders.…”

“…The n-6 PUFA-derived lipid mediators have been associated with pro-inflammatory processes, whereas those of n-3 are described to have anti-inflammatory effects [20]. It is well demonstrated that n-3 PUFA, particularly EPA and DHA, are associated with decreased risk of CVD, type 2 diabetes, metabolic syndrome, breast cancer, and depression in different populations [6,15,[21][22][23][24][25]. Higher n-3 PUFA levels of red blood cells are associated with a reduced risk of all-cause mortality [26,27].…”