Omentin-1, a Novel Adipokine, Is Decreased in Overweight Insulin-Resistant Women With Polycystic Ovary Syndrome

Tan, Bee K.; Adya, Raghu; Syed, Farhatullah; Lewandowski, Krzysztof C.; O’Hare, J. Paul; Lehnert, Hendrik; Randeva, Harpal S.

doi:10.2337/db07-0990

Cited by 264 publications

(245 citation statements)

References 19 publications

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“…8 It has also been reported that glucose treatment reduces omentin expression and secretion in omental fat tissue explants. 10 Consistent with these observations, our present data Omentin and carotid intima-media thickness R Shibata et al showed that plasma omentin levels negatively associated with glucose levels. Our data also demonstrated that circulating omentin levels correlated inversely with creatinine levels, and positively with eGFR.…”

Section: Discussionsupporting

confidence: 92%

“…7,8 Low levels of plasma omentin are also associated with insulin resistance and endothelial dysfunction. 9,10 Thus, it is conceivable that circulating omentin is associated with obesity-linked disorders. An increase in carotid arterial intima-media thickness (IMT) is an established marker of early atherosclerosis and is predictive of future cardiovascular and stroke events.…”

Section: Introductionmentioning

confidence: 99%

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Association of a fat-derived plasma protein omentin with carotid artery intima-media thickness in apparently healthy men

et al. 2011

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Obesity is causally linked with the development of atherosclerosis. Omentin is an adipocytokine whose concentrations are reduced in obese individuals. Here we examined the relationship between plasma omentin levels and carotid intima-media thickness (IMT), a marker of early atherosclerosis, in apparently healthy Japanese men. Participants were 100 Japanese men who underwent a medical checkup. Maximal IMT (max-IMT) and mean-IMT in common carotid artery were measured by highresolution carotid ultrasound system. Plasma omentin concentrations were determined by enzyme-linked immunosorbent assay. Circulating omentin levels correlated negatively with body mass index, waist circumference, fasting glucose, creatinine, max-IMT and mean-IMT, and positively with estimated glomerular filtration rates (eGFR). Single regression analysis demonstrated that max-IMT associated with age, eGFR and omentin levels, and that mean-IMT associated with age, fasting glucose, eGFR and omentin levels. Multiple regression analysis revealed that omentin levels, together with age, correlated with max-IMT and mean-IMT. Our data document that circulating omentin levels independently and negatively associate with carotid IMT in this population, suggesting that measurement of omentin may be useful for assessment of carotid IMT.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Association of a fat-derived plasma protein omentin with carotid artery intima-media thickness in apparently healthy men

et al. 2011

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“…Furthermore, omentin-1 enhances insulin action and Akt phosphorylation [14]; it is inversely related to obesity [15] and is down regulated by insulin and glucose [13]. In an in vitro study to investigate the effects of omentin-1 on bone metabolism, omentin-1 reduced osteoclast formation by stimulating OPG and inhibiting RANKL production in osteoblasts [16].…”

Section: Introductionmentioning

confidence: 99%

Omentin-1, visfatin and adiponectin levels in relation to bone mineral density in Iranian postmenopausal women

Tohidi

Akbarzadeh

Larijani

et al. 2012

Bone

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The bone and fat interface is implicated in the pathogenesis of postmenopausal osteoporosis. The association between circulating omentin-1 levels and bone mineral density (BMD) in postmenopausal women has never been assessed. A total of 382 healthy postmenopausal women were randomly selected. Omentin-1, visfatin, adiponectin, the receptor activator of nuclear factor-κB ligand (RANKL), osteoprotegerin, high sensitivity C-reactive protein, degradation products of C-terminal telopeptides of type I collagen, and osteocalcin were measured by highly specific enzyme-linked immunosorbent assay methods. BMD was determined for the lumbar spine (L2-L4) and the proximal femur using dual-energy X-ray absorptiometry. In multivariable-adjusted linear regression, serum omentin-1 levels were inversely correlated with BMD at the lumbar spine (β =−0.11, p= 0.020). In multiple regression analyses, serum visfatin and adiponectin levels were not significantly correlated with BMD at different skeletal sites after controlling for age, body mass index, and bone-related markers. However, the highest quartile of adiponectin compared to the lowest quartile, after adjusting for potential confounders, revealed an inverse association with BMD in the lumbar spine (β=−0.19, p=0.010). In conclusion, circulating omentin-1 levels had an inverse correlation with BMD at the lumbar spine in Iranian postmenopausal women. To further understand the role of omentin-1 in bone and mineral metabolism, large-scale longitudinal studies focusing on BMD and osteoporotic fractures are warranted.

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“…We can postulate that the reduction in omentin-1 levels in subjects with MetS may be due to peripheral adiposity. Insulin resistance and hyperglycemia are the core processes and important risk factors for MetS, which significantly reduce the expression of omentin mRNA and its translation (28). Therefore, omentin-1 probably depresses the metabolic syndrome process throughout glucose metabolism normalization.…”

Section: Discussionmentioning

confidence: 99%

Association Between Omentin, Visfatin and Insulin-Like Growth Factor-1 in Women With Metabolic Syndrome

Goodarzi¹,

Borzuei²,

Farimani³

et al. 2014

Avicenna J Med Biochem

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Background: Adipokines that are produced by adipose tissue have extensive effects on carbohydrate and lipid metabolism and also on the pathogenesis of the metabolic syndrome (MetS). Objectives: This study aimed to measure the concentrations of omentin-1, visfatin and insulin-like growth factor-1 (IGF-1) as likely markers of metabolic syndrome and also to demonstrate their associations in women with MetS. Materials and Methods: Eighty women with MetS and eighty healthy women as controls participated in this study. Blood pressure, waist circumference, body mass index (BMI), and serum biochemical parameters were determined in all subjects. The serum level of IGF-1, omentin-1 and visfatin were assessed using the enzyme linked immunosorbent assay (ELISA). The association between omentin, visfatin and IGF-1 was also determined in these women. Results: Significantly lower levels of omentin-1 and IGF-1 were observed in MetS subjects compared to the controls (P = 0.009 and < 0.001 respectively). However, a significant difference was not observed in visfatin concentration between the two studied groups (P = 0.67). A positive association was observed between omentin-1, visfatin and IGF-1 in the MetS group. Conclusions: Our findings indicated a lower level of both omentin-1 and IGF-1 in women with MetS; this might play a role in the pathogenesis of MetS. Furthermore, the main finding of the current investigation was the association between omentin, visfatin and IGF-1; however determining the molecular mechanism of the observed relationships needs further studies.

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Omentin-1, a Novel Adipokine, Is Decreased in Overweight Insulin-Resistant Women With Polycystic Ovary Syndrome

Cited by 264 publications

References 19 publications

Association of a fat-derived plasma protein omentin with carotid artery intima-media thickness in apparently healthy men

Association of a fat-derived plasma protein omentin with carotid artery intima-media thickness in apparently healthy men

Omentin-1, visfatin and adiponectin levels in relation to bone mineral density in Iranian postmenopausal women

Association Between Omentin, Visfatin and Insulin-Like Growth Factor-1 in Women With Metabolic Syndrome

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