Omentin-1 in diabetes mellitus: A systematic review and meta-analysis

Pan, Xiongfeng; Kaminga, Atipatsa Chiwanda; Wen, Shi Wu; Acheampong, Kwabena; Liu, Aizhong

doi:10.1371/journal.pone.0226292

Cited by 52 publications

(33 citation statements)

References 39 publications

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“…Significantly lower omentin-1 concentrations were observed in people with GDM or T2DM than in the controls by Pan et al, whereas no difference was found between the T1DM and controls [ 166 ]. Decreased omentin-1 concentrations may be an important indicator of gestational diabetes mellitus and type 2 diabetes mellitus.…”

Section: Clinical Applications Of Adipokines Measurements In Variomentioning

confidence: 99%

The Role of the Adipokines in the Most Common Gestational Complications

Gutaj

Sibiak

Jankowski

et al. 2020

IJMS

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Adipocytokines are hormonally active molecules that are believed to play a key role in the regulation of crucial biological processes in the human body. Numerous experimental studies established significant alterations in the adipokine secretion patterns throughout pregnancy. The exact etiology of various gestational complications, such as gestational diabetes, preeclampsia, and fetal growth abnormalities, needs to be fully elucidated. The discovery of adipokines raised questions about their potential contribution to the molecular pathophysiology of those diseases. Multiple studies analyzed their local mRNA expression and circulating protein levels. However, most studies report conflicting results. Several adipokines such as leptin, resistin, irisin, apelin, chemerin, and omentin were proposed as potential novel early markers of heterogeneous gestational complications. The inclusion of the adipokines in the standard predictive multifactorial models could improve their prognostic values. Nonetheless, their independent diagnostic value is mostly insufficient to be implemented into standard clinical practice. Routine assessments of adipokine levels during pregnancy are not recommended in the management of both normal and complicated pregnancies. Based on the animal models (e.g., apelin and its receptors in the rodent preeclampsia models), future implementation of adipokines and their receptors as new therapeutic targets appears promising but requires further validation in humans.

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Section: Clinical Applications Of Adipokines Measurements In Variomentioning

confidence: 99%

The Role of the Adipokines in the Most Common Gestational Complications

Gutaj

Sibiak

Jankowski

et al. 2020

IJMS

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“…Simultaneously, the levels of anti-inflammatory adipokines, e.g., adiponectin, omentin decrease. The above biological events trigger a redox imbalance between ROS production and their scavenging, leading to induction of low grade chronic inflammation and intensification of OxS-paving the way for MetS [72,76,79,80]. These phenomena vastly affect WAT, which becomes insulin-resistant, and initiates hyperinsulinemia, enhances lipolysis, increases levels of circulating FFA and their deposition in muscles, liver and pancreas, followed by lipotoxicity, elevated production of glucose due to increased gluconeogenesis and glycogenolysis, and finally, systemic IR and HG [72,81].…”

Section: Hypertrophic Hypoxic and Inflamed White Adipose Tissue-thementioning

confidence: 99%

The Role of microRNAs in Metabolic Syndrome-Related Oxidative Stress

Włodarski

Strycharz

Wróblewski

et al. 2020

IJMS

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Oxidative stress (OxS) is the cause and the consequence of metabolic syndrome (MetS), the incidence and economic burden of which is increasing each year. OxS triggers the dysregulation of signaling pathways associated with metabolism and epigenetics, including microRNAs, which are biomarkers of metabolic disorders. In this review, we aimed to summarize the current knowledge regarding the interplay between microRNAs and OxS in MetS and its components. We searched PubMed and Google Scholar to summarize the most relevant studies. Collected data suggested that different sources of OxS (e.g., hyperglycemia, insulin resistance (IR), hyperlipidemia, obesity, proinflammatory cytokines) change the expression of numerous microRNAs in organs involved in the regulation of glucose and lipid metabolism and endothelium. Dysregulated microRNAs either directly or indirectly affect the expression and/or activity of molecules of antioxidative signaling pathways (SIRT1, FOXOs, Keap1/Nrf2) along with effector enzymes (e.g., GPx-1, SOD1/2, HO-1), ROS producers (e.g., NOX4/5), as well as genes of numerous signaling pathways connected with inflammation, insulin sensitivity, and lipid metabolism, thus promoting the progression of metabolic imbalance. MicroRNAs appear to be important epigenetic modifiers in managing the delicate redox balance, mediating either pro- or antioxidant biological impacts. Summarizing, microRNAs may be promising therapeutic targets in ameliorating the repercussions of OxS in MetS.

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“…There are convincing data from experimental and clinical studies on the effects of omentin-1 on vascular reactivity and atherogenesis. Experimental studies have shown that omentin-1 causes vasodilation of isolated blood vessels of rats by increasing the activity of endothelial nitric oxide synthase and stimulates ischemia-induced revascularization in mice [4]. Omentin-1 modulates endothelial cell function and revascularization processes.…”

Section: Resultsmentioning

confidence: 99%

Pathophysiological association of expression hormone of adipose tissue omentin-1 and the degree of vascular remodeling of brachyocephalic vessels in persons with obesity and disorders of carbohydrate metabolism

Kulynych¹,

Soloviuk²,

Soloviuk³

2020

J Educ Health Sport

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Introduction. The relationship of visceral obesity and excess body weight (EBW) with the development of cardiovascular diseases, type 2 diabetes mellitus (DM) and effect on quality and duration of life determine the relevance of studying this problem. Objective: to assess omentin-1 metabolism and pathophysiological relationship between its level and the severity of lesions in the intima-media thickness (IMT) of the carotid arteries in type 2 DM in combination with EBW and obesity. Material and research methods. We examined 98 people with DM, the first group consisted of 64 people with EBW and obesity, second group consisted of 34 people with normal body weight, control group-28 healthy individuals. Research results. Evaluation of the correlation matrix showed the presence of a positive rather strong negative connection between IMT, especially the right carotid artery and the level of omentin-1 in the blood (Rs =-0.55; p = 0.002). According to the results of

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Omentin-1 in diabetes mellitus: A systematic review and meta-analysis

Cited by 52 publications

References 39 publications

The Role of the Adipokines in the Most Common Gestational Complications

The Role of the Adipokines in the Most Common Gestational Complications

The Role of microRNAs in Metabolic Syndrome-Related Oxidative Stress

Pathophysiological association of expression hormone of adipose tissue omentin-1 and the degree of vascular remodeling of brachyocephalic vessels in persons with obesity and disorders of carbohydrate metabolism

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