Omeprazole, Nitrendipine, Famotidine and Stress-Induced Ulcers

Inaloz, Serhat; Göral, Vedat; Sari, Ika Puspita; Canberk, Yurdagül; Ulak, Güner

doi:10.55730/1300-0144.5018

Cited by 4 publications

(1 citation statement)

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“…The elimination half-life is approximately 2-4 h, which is expected to increase nonlinearly in patients with decreased renal function. [5][6][7] Due to the adverse effects of the central nervous system, longer dosing intervals or reduced doses may be used instead to adjust for the resulting longer elimination halflife of FMT. [8][9][10] Intravenous formulations have local adverse effects such as irritation at the injection site; moreover, fre-quent administration results in low patient compliance.…”

Section: Introductionmentioning

confidence: 99%

Promoting Activity of Terpenes on Skin Permeation of Famotidine

Saito

et al. 2023

CHEMICAL & PHARMACEUTICAL BULLETIN

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Famotidine (FMT) is a competitive histamine-2 (H2) receptor antagonist that inhibits gastric acid secretion for the treatment of Gastroesophageal reflux disease. To study the promoting effect and mechanism of terpenes, including l-menthol, borneol, and geraniol, as chemical enhancers, FMT was used as a model drug. Attenuated total reflectance-Fourier transform IR spectroscopy (ATR-FTIR) and differential scanning calorimetry (DSC) were used to explore the effects of terpenes on the skin. Hairless mouse skin was mounted on Franz-type diffusion cell, and skin permeation experiment of FMT hydrogel was carried out. The results suggested that the thermodynamic activity influenced the permeability of the drug, and the main mechanism of terpenes to enhance skin permeation of the drug was based on increasing the fluidity of the intercellular lipids. Moreover, it was revealed that l-menthol simultaneously relaxed the packing structure and lamellar structure, whereas geraniol had a great influence on the lamellar structure only. Collectively, all terpenes had a promoting effect on skin permeation of FMT, indicating their potential as chemical enhancers to change the microstructure of stratum corneum and improve the permeation of FMT through the skin, and it has great potential to be used in transdermal formulations of FMT.

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Section: Introductionmentioning

confidence: 99%

Promoting Activity of Terpenes on Skin Permeation of Famotidine

Saito

et al. 2023

CHEMICAL & PHARMACEUTICAL BULLETIN

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Pharmacologic Prophylaxis and Treatment of Stress Ulcers in Critically Ill Patients

Flannery

Tucker

2002

Critical Care Nursing Clinics of North America

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Bilici

Banoğlu

Kızıltunç

et al. 2002

Digestive Diseases and Sciences

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It is known that calcium ion has an important role in the cellular function. For this reason, calcium channel blockers may have a protective action against gastric injury which is induced by various stimuli. In this study, the influence of mibefradil on ethanol-induced gastric injury was investigated in rats. Mibefradil was given at a dose 50 mg/kg intraperitoneally 30 min before administration of 1 ml absolute ethanol given by gavage. We compared this effect of mibefradil with that of omeprazol. Ethanol-induced mucosal damage was evaluated using three different approaches: analysis of biochemical parameters and pathologic and macroscopic investigation. It was found that pretreatment with mibefradil significantly reduced ethanol-induced macroscopic, pathologic, and biochemical changes in the gastric mucosa. In conclusion, it is speculated that this findings may prove important in the development of new and improved therapies for the treatment and prevention of gastric ulcers in humans.

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Omeprazole, Nitrendipine, Famotidine and Stress-Induced Ulcers

Cited by 4 publications

References 0 publications

Promoting Activity of Terpenes on Skin Permeation of Famotidine

Promoting Activity of Terpenes on Skin Permeation of Famotidine

Pharmacologic Prophylaxis and Treatment of Stress Ulcers in Critically Ill Patients

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