<abstract><p>In this article, we study the existence and uniqueness results for a sequential nonlinear Caputo fractional sum-difference equation with fractional difference boundary conditions by using the Banach contraction principle and Schaefer's fixed point theorem. Furthermore, we also show the existence of a positive solution. Our problem contains different orders and four fractional difference operators. Finally, we present an example to display the importance of these results.</p></abstract>