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To my wife Anindita -Ananda S. ChowdhuryTo my wife Swati, son Pranav, and daughter Asha -Suchendra M. Bhandarkar Foreword An ancient mariner on the open seas had to know where he is before he could navigate to where he had to go. A surgeon, through training and experience, gains a mental image of what that "map" should be. It is called surgical anatomy. This is possible because for the most part, the human anatomy, at the large-scale level (1 cm to 10 cm, for example), is not exceedingly variable. However, to know the precise location of the surgery, dissection is needed to allow either direct visualization or palpation of the particular anatomic structures. Often, such dissection is associated with disruption of normal tissues, interruption of blood supply, prolonging the magnitude of surgery, increasing the risk of potential complications, and lengthening the post-operative convalescence. In recent times, Computer Tomography (CT) and Magnetic Resonance Imaging (MRI) have allowed the surgeon to see this surgical map at a level of detail and precision not previously possible. Recent advances in both scanning instruments and supporting software have transitioned their impact from merely outside the operating room to inside the surgical theater, making intraoperative 3D imaging a reality.However, most of the existing intraoperative navigation devices are still bulky, time-consuming to use, and increase the potential for contaminating the sterile operative field. Given that the cost per minute in the operating room continues to sky rocket, the more work that can be done before entering the operating room, the more effective and efficient the surgeon can be. This monograph details a collaborative research endeavor over the past five years at the University of Georgia and the Medical College of Georgia in designing a software system that can reconstitute broken bones in silico, either through a graphical user interface or in an automated fashion from fracture detection to fracture reduction-a process where the displaced bone fragments are returned to where they should be. The sizes and shapes of the fractured bone(s) and the shape of the in silico reconstruction can be obtained and then linked to CAD-CAM ...