2002
DOI: 10.1055/s-0038-1632727
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On age-related mammalian bone loss: Insights of the Utah paradigm

Abstract: SummaryAn elegant design stratagem would make its loads control the strength of an organ intended to carry loads without breaking. Healthy load-bearing mammalian bones do exactly that. Physiologists begin to understand how they do it, and this article reviews some of the biological “machinery” responsible for it. Why? Because that machinery’s features show what can cause age-related bone loss, how it occurs, how a long-overlooked mechanism in bone marrow would contribute to it, why loss of whole-bone strength … Show more

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