On and Off magnetic auditory evoked responses in early infancy: A possible marker of brain immaturity

Wakai, Ronald T.; Lutter, William J.; Chen, M.; Maier, Mary M.

doi:10.1016/j.clinph.2007.04.003

Cited by 24 publications

(19 citation statements)

References 19 publications

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“…The amplitudes of the onsetand offset-responses in infants also seem to be valid markers of brain immaturity. Wakai et al (2007) found that small on-response amplitudes compared to the off-response amplitudes in individual infants were observed in the immature brains. In the future, these types of responses may prove to be useful in assessing the auditory skills very early in life.…”

Section: Event-related Responses Reflecting the Auditory Skillsmentioning

confidence: 94%

Using magnetoencephalography in assessing auditory skills in infants and children

Huotilainen

Шестакова

Hukki

2008

International Journal of Psychophysiology

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Section: Event-related Responses Reflecting the Auditory Skillsmentioning

confidence: 94%

Using magnetoencephalography in assessing auditory skills in infants and children

Huotilainen

Шестакова

Hukki

2008

International Journal of Psychophysiology

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“…Similarly, during the first 3 postnatal mo, PET activity increases more in the low-expanding (V1) than in the high-expanding (DLPFC) regions (26,38). Activity in the low-expanding auditory cortex in response to sound (39) and medial temporal cortex in response to visually presented faces (40,41) can be detected by PET imaging or scalp recording within the first 2 postnatal mo. In contrast, transcranial magnetic stimulation of the high-expanding motor cortex does not elicit detectable muscle response in humans until 2 y of age (42,43).…”

Section: High-expanding Regions Have Greater Cellular Complexity In Amentioning

confidence: 99%

Similar patterns of cortical expansion during human development and evolution

Hill¹,

Inder²,

Neil³

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

686

589

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The cerebral cortex of the human infant at term is complexly folded in a similar fashion to adult cortex but has only one third the total surface area. By comparing 12 healthy infants born at term with 12 healthy young adults, we demonstrate that postnatal cortical expansion is strikingly nonuniform: regions of lateral temporal, parietal, and frontal cortex expand nearly twice as much as other regions in the insular and medial occipital cortex. This differential postnatal expansion may reflect regional differences in the maturity of dendritic and synaptic architecture at birth and/or in the complexity of dendritic and synaptic architecture in adults. This expression may also be associated with differential sensitivity of cortical circuits to childhood experience and insults. By comparing human and macaque monkey cerebral cortex, we infer that the pattern of human evolutionary expansion is remarkably similar to the pattern of human postnatal expansion. To account for this correspondence, we hypothesize that it is beneficial for regions of recent evolutionary expansion to remain less mature at birth, perhaps to increase the influence of postnatal experience on the development of these regions or to focus prenatal resources on regions most important for early survival.T he human cerebral cortex is characterized by regional nonuniformities in cellular structure that change with age. Near term, there are regional variations in synaptic density (1, 2), dendritic length, and dendritic spine density (3). Postnatally, synaptic density increases dramatically, reaches a peak density in early childhood, and then undergoes synaptic pruning with a 2-fold or greater reduction (4). The time course of these synaptic changes differs across regions, with primary sensory areas attaining peak density and adult levels earlier than higher order "association" areas (2, 5). In adults, there are large regional nonuniformities in neuronal density (6), dendritic size, branching complexity, and spine density (7).This evidence for cellular nonuniformities provides grounds for anticipating regional differences in macroscopic aspects of postnatal cortical maturation. Indeed, studies of gray matter volume and overall brain growth provide evidence for complex regional patterns of morphological change during childhood and adolescence (8, 9). We recently used a surface-based approach to compare cortical structure in human term infants to adults. That analysis suggested that although many adult cortical shape characteristics are well established at birth, there may be regional differences in the maturity of cortical folding in term infants compared with adults (10).Comparisons with nonhuman primates, especially the intensively studied macaque monkey, provide another basis for evaluating regional differences in cortical maturation. Since the evolutionary divergence between humans and macaques ∼25 million years ago (11), cortical expansion has been far greater in human lineage than in the macaque lineage. Compared with the macaque cortex, the human c...

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“…Infant language development has also been studied with ERPs (Buiatti et al, 2009; Cohen et al, 2000; Dehaene-Lambertz et al, 2006). MEG has become a new modality of studying infant brain activity in infant speech perception (Imada et al, 2006; Kujala et al, 2004), sensory perception during sleep (Kakigi et al, 2003), somatosensory development (Pihko et al, 2009), vision (Haddad et al, 2006), and auditory response as an immature brain marker (Wakai et al, 2007). MEG instruments optimized for the pediatric population are beginning to be developed (e.g.…”

Section: Introductionmentioning

confidence: 99%

Effects of sutures and fontanels on MEG and EEG source analysis in a realistic infant head model

et al. 2013

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In infants, the fontanels and sutures as well as conductivity of the skull influence the volume currents accompanying primary currents generated by active neurons and thus the associated electroencephalography (EEG) and magnetoencephalography (MEG) signals. We used a finite element method (FEM) to construct a realistic model of the head of an infant based on MRI images. Using this model, we investigated the effects of the fontanels, sutures and skull conductivity on forward and inverse EEG and MEG source analysis. Simulation results show that MEG is better suited than EEG to study early brain development because it is much less sensitive than EEG to distortions of the volume current caused by the fontanels and sutures and to inaccurate estimates of skull conductivity. Best results will be achieved when MEG and EEG are used in combination.

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On and Off magnetic auditory evoked responses in early infancy: A possible marker of brain immaturity

Abstract: Measurement of auditory off-responses can improve the assessment of infant neurodevelopment, potentially providing a marker of brain immaturity.

Cited by 24 publications

References 19 publications

Using magnetoencephalography in assessing auditory skills in infants and children

Using magnetoencephalography in assessing auditory skills in infants and children

Similar patterns of cortical expansion during human development and evolution

Effects of sutures and fontanels on MEG and EEG source analysis in a realistic infant head model

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