On-chip electromagnetic tweezers – 3-dimensional particle actuation using microwire crossbar arrays

Abstract

Emerging miniaturization technologies for biological and bioengineering applications require precise control over position and actuation of microparticles. While many of these applications call for high-throughput approaches, common tools for particle manipulation, such as magnetic or optical tweezers, suffer from low parallelizability. To address this issue, we introduce a chip-based platform that enables flexible three-dimensional control over individual magnetic microparticles. Our system relies on microwire crossbar arrays for simultaneous generation of magnetic and dielectric forces, which actuate the particles along highly localized traps. We demonstrate the precise spatiotemporal control of individual particles by tracing complex trajectories in three dimensions and investigate the forces that can be generated along different axes. Furthermore, we show that our approach for particle actuation can be parallelized by simultaneously controlling the position and movement of 16 particles in parallel.

Antimicrobial Metal Nanomaterials: From Passive to Stimuli‐Activated Applications

“…A major advantage of magnetophysical particles is the capacity to spatially control the treatment area, through control over the applied magnetic field. Currently, this level of spatial control has only been observed in two dimensions, however, with continual advances in noncontact control of magnetic particles in 3D space, [ 283 ] there is potential that the spatial control demonstrated in two dimensions can be translated to 3D space, ensuring such particles are clinically relevant. Additionally, antimicrobial activity appears to be controlled by the absence/presence of an external magnetic field, demonstrating the temporal control of the treatment.…”

Multifarious Transit Gates for Programmable Delivery of Bio‐functionalized Matters

“…On the other hand, the optical image‐driven dielectrophoresis enables many objects to be controllable with high resolution, and requires 100 000 times less optical intensity than optical tweezers . The microelectromagnet arrays have also been utilized to massively control particles, but they produce local heating due to currents applied in the wires . Furthermore, surface acoustic waves and mobile microrobots can be used to manipulate single or multiple particles, cells, and organisms.…”

“…[8] The microelectromagnet arrays have also been utilized to massively control particles, but they produce local heating due to currents applied in the wires. [9] Furthermore, surface acoustic waves [10] and mobile microrobots [11] can be used to manipulate single or multiple particles, cells, and organisms. However, none of these approaches have demonstrated the simultaneous programmable manipulation of individual objects for massive arrays without any damage to biomolecules.…”

Радиальные домены в микропроводах DyPr-FeCo-B

“…Дорожная карта магнетизма [13] очерчивает новые пути для развития физики микропроводов и создания многофазных микропроводов, сочетающих переходные и редкоземельные металлы. Разработка магнитно-модулированных структур на основе микропроводов позволит их применять в биомедицинских технологиях [14], поскольку период пространственного распределения магнитного поля рассеяния вдоль микропровода сопоставим с типичными размерами живых клеток ∼ 1 µm [7,9]. Спонтанная " магнитная модуляция", возникающая в виде радиальных поверхностных доменов с перпендикулярным направлением намагниченности, может быть использована в магнитных манипуляторах для перемещения магнитомеченных клеток и биомолекул.…”