On-chip manipulation of free droplets

Velev, Orlin D.; Prevo, Brian G.; Bhatt, Ketan H.

doi:10.1038/426515a

Cited by 333 publications

(280 citation statements)

References 13 publications

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“…In several lab-on-a-chip applications, droplet manipulation has been demonstrated using electrohydrodynamic (EHD) forces. [13][14][15] Systems based on electrowetting [16][17][18] and dielectrophoresis 19,20 have also been used to dispense, transport, merge, and divide droplets. These approaches are not limited to unidirectional serial flow processes, where segregated samples are periodically generated and transported in the same direction through microchannels; rather, they allow droplets to be transported arbitrarily on a microfabricated control grid.…”

Section: Microfluidic Implementationmentioning

confidence: 99%

Digital microfluidics using soft lithography

et al. 2006

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Although microfluidic chips have demonstrated basic functionality for single applications, performing varied and complex experiments on a single device is still technically challenging. While many groups have implemented control software to drive the pumps, valves, and electrodes used to manipulate fluids in microfluidic devices, a new level of programmability is needed for end users to orchestrate their own unique experiments on a given device. This paper presents an approach for programmable and scalable control of discrete fluid samples in a polydimethylsiloxane (PDMS) microfluidic system using multiphase flows. An immiscible fluid phase is utilized to separate aqueous samples from one another, and a novel ''microfluidic latch'' is used to precisely align a sample after it has been transported a long distance through the flow channels. To demonstrate the scalability of the approach, this paper introduces a ''generalpurpose'' microfluidic chip containing a rotary mixer and addressable storage cells. The system is general purpose in that all operations on the chip operate in terms of unit-sized aqueous samples; using the underlying mechanisms for sample transport and storage, additional sensors and actuators can be integrated in a scalable manner. A novel high-level software library allows users to specify experiments in terms of variables (i.e., fluids) and operations (i.e., mixes) without the need for detailed knowledge about the underlying device architecture. This research represents a first step to provide a programmable interface to the microfluidic realm, with the aim of enabling a new level of scalability and flexibility for lab-on-a-chip experiments.

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Section: Microfluidic Implementationmentioning

confidence: 99%

Digital microfluidics using soft lithography

et al. 2006

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“…A trigger can be a temperature increase [448], pH change [449], added chemicals [191], external electric [450] and magnetic [223] fields, microwave radiation [451] or light [452]. The response of these smart materials can be controlled in an automated way to obtain novel devices.…”

Section: Future Applicationsmentioning

confidence: 99%

Porous polymer particles—A comprehensive guide to synthesis, characterization, functionalization and applications

Gökmen

Prez

2012

Progress in Polymer Science

451

309

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“…The manipulation of the microfluidics is one of the most important applications in microelectromechanical systems (MEMS), such as the lab-on-a-chip and biomedical microdevice systems [1][2][3][4]. The classical effect of electrowetting on dielectric (EWOD) [5,6] is to make a droplet flatten and spread by applying voltage between the electrodes in the droplet and under the dielectric coating.…”

Section: Introductionmentioning

confidence: 99%

An Electrowetting Model for Rough Surfaces Under Low Voltage

Dai¹,

Zhao²

2008

Journal of Adhesion Science and Technology

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Electrowetting is one of the most effective methods to enhance wettability. A significant change of contact angle for the liquid droplet can result from the surface microstructures and the external electric field, without altering the chemical composition of the system. During the electrowetting process on a rough surface, the droplet exhibits a sharp transition from the Cassie-Baxter to the Wenzel regime at a low critical voltage. In this paper, a theoretical model for electrowetting is put forth to describe the dynamic electrical control of the wetting behavior at the low voltage, considering the surface topography. The theoretical results are found to be in good agreement with the existing experimental results.  Koninklijke Brill NV, Leiden, 2008

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On-chip manipulation of free droplets

Cited by 333 publications

References 13 publications

Digital microfluidics using soft lithography

Digital microfluidics using soft lithography

Porous polymer particles—A comprehensive guide to synthesis, characterization, functionalization and applications

An Electrowetting Model for Rough Surfaces Under Low Voltage

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