On ciprofloxacin concentration in chronic rhinosinusitis

Santos, José Gameiro dos; Figueirinhas, Rosário; Liberal, José P.; Almeida, João Carvalho; Sousa, Jorge; Falcão, Amı́lcar; Vicente, Córalia; Paço, João; Sousa, Cecília Almeida e

doi:10.1016/j.otorri.2017.06.008

Cited by 5 publications

(1 citation statement)

References 15 publications

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“…From the zeta potential values, all S-CDs synthesized at a flow rate of 1 mL min −1 showed high stability of nanoparticles in the aqueous phase. Since it has been reported that CP molecule becomes positively charged because of the protonation of the amine group [ 53 ], consequently negatively charged S-CDs exhibited a possibility on effectively conjugating with CP [ 7 ] for antimicrobial drug delivery application. The %mass yields of S-CDs synthesized via a continuous hydrothermal process at a flow rate of 1 mL min −1 at various temperature from 240 to 280°C are shown in Figure S15(b).…”

Section: Resultsmentioning

confidence: 99%

Scaling-up of carbon dots hydrothermal synthesis from sugars in a continuous flow microreactor system for biomedical application as in vitro antimicrobial drug nanocarrier

Supajaruwong,

Porahong,

Wibowo

et al. 2023

Science and Technology of Advanced Materials

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Carbon dots (CDs) are a new class of nanomaterials exhibiting high biocompatibility, water solubility, functionality, and tunable fluorescence (FL) property. Due to the limitations of batch hydrothermal synthesis in terms of low CDs yield and long synthesis duration, this work aimed to increase its production capacity through a continuous flow reactor system. The influence of temperature and time was first studied in a batch reactor for glucose, xylose, sucrose and table sugar precursors. CDs synthesized from sucrose precursor exhibited the highest quantum yield (QY) (175.48%) and the average diameter less than 10 nm (~6.8 ± 1.1 nm) when synthesized at 220°C for 9 h. For a flow reactor system, the best condition for CDs production from sucrose was 1 mL min −1 flow rate at 280°C, and 0.2 MPa pressure yielding 53.03% QY and ~ 6.5 ± 0.6 nm average diameter (6.6 mg min −1 of CDs productivity). CDs were successfully used as ciprofloxacin (CP) nanocarrier for antimicrobial activity study. The cytotoxicity study showed that no effect of CDs on viability of L-929 fibroblast cells was detected until 1000 µg mL −1 CDs concentration. This finding demonstrates that CDs synthesized via a flow reactor system have a high zeta potential and suitable surface properties for nano-theranostic applications.

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Section: Resultsmentioning

confidence: 99%