We establish the vanishing viscosity limit of the Navier-Stokes equations to the Euler equations for three-dimensional compressible isentropic flow in the whole space. When the viscosity coefficients are given as constant multiples of the density's power (ρ δ with δ > 1), it is shown that there exists a unique regular solution of compressible Navier-Stokes equations with arbitrarily large initial data and vacuum, whose life span is uniformly positive in the vanishing viscosity limit. It is worth paying special attention that, via introducing a " quasi-symmetric hyperbolic"-"degenerate elliptic" coupled structure to control the behavior of the velocity of the fluid near the vacuum, we can also give some uniform estimates for ρ γ−1 2 , u in H 3 and ρ δ−1 2 in H 2 with respect to the viscosity coefficients (adiabatic exponent γ > 1 and 1 < δ ≤ min{3, γ}), which lead the strong convergence of the regular solution of the viscous flow to that of the inviscid flow in L ∞ ([0, T ]; H s ′ ) (for any s ′ ∈ [2, 3)) with the rate of ǫ 2(1−s ′ /3) . Further more, we point out that our framework in this paper is applicable to other physical dimensions, say 1 and 2, with some minor modifications.