On-Column Preconcentration of Anti-Inflammatory Drugs in River Water by Anion-Selective Exhaustive Injection-Sweeping-MEKC

Maijó, Irene; Borrull, Francesc; Aguilar, Carme; Calull, Marta

doi:10.1007/s10337-010-1817-1

Cited by 13 publications

(11 citation statements)

References 31 publications

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“…An off‐line SPE step was also required to minimize the influence of the matrix. Only one contribution to ASEI‐sweeping in MEKC‐based determinations was reported in the reviewed period, namely: the determination of nonsteroidal anti‐inflammatory drugs (diclofenac sodium, ibuprofen, fenoprofen, naproxen, ketoprofen) in river water with direct injection of the sample . Under optimal conditions, the enrichment factors achieved for these five drugs with no sample pretreatment fell in the range 162–260, and LODs in the 29–58 ng/mL range.…”

Section: Online Sample Concentration Techniquesmentioning

confidence: 99%

Micellar electrokinetic chromatography: A review of methodological and instrumental innovations focusing on practical aspects

Silva

2012

Electrophoresis

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This review article addresses recent methodological and instrumental innovations in MEKC with emphasis on practical aspects. Like its predecessors, this review is intended to provide an updated overview covering work on the most salient methodological contributions to enhancing sensitivity and resolution in MEKC-based determinations published over the past two years. The most widespread approaches to enhancing sensitivity, which include improving "classical" online sample concentration techniques, combinations of on- and off-line sample concentration protocols and recent developments are discussed, and so are modifications of existing MEKC systems with various micellar phases, the use of BGE additives (organic modifiers, chiral selectors, gold nanoparticles) and coated capillaries, and the implementation of 2D separations and chemometric methods to enhance resolution. Instrumental approaches such as MS and LIF are also discussed, and proposals for overcoming the problems typically encountered in directly coupling MEKC with MS, and the recent inception of quantum dots with a great potential for LIF detection in MEKC, are also dealt with. Finally, foreseeable developments on potential future directions are also expressed.

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Section: Online Sample Concentration Techniquesmentioning

confidence: 99%

Micellar electrokinetic chromatography: A review of methodological and instrumental innovations focusing on practical aspects

Silva

2012

Electrophoresis

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“…Popularly used was CSEI‐sweeping . Other sequential stacking techniques employed were anion‐selective exhaustive injection (ASEI)‐sweeping , dynamic pH junction‐sweeping , LVSS‐sweeping , t‐ITP‐sweeping , sweeping‐MSS . The use of triple stacking was also reported such as chitosan sweeping‐reversed field stacking‐FASS , and FASS‐pH junction‐sweeping .…”

Section: Sequential Stacking Methodsmentioning

confidence: 99%

Recent advances in enhancing the sensitivity of electrophoresis and electrochromatography in capillaries and microchips (2010–2012)

et al. 2013

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CE has been alive for over two decades now, yet its sensitivity is still regarded as being inferior to that of more traditional methods of separation such as HPLC. As such, it is unsurprising that overcoming this issue still generates much scientific interest. This review continues to update this series of reviews, first published in Electrophoresis in 2007, with updates published in 2009 and 2011 and covers material published through to June 2012. It includes developments in the field of stacking, covering all methods from field amplified sample stacking and large volume sample stacking, through to isotachophoresis, dynamic pH junction and sweeping. Attention is also given to online or inline extraction methods that have been used for electrophoresis.

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“…Sweeping techniques have been demonstrated for the analysis of hydrophobic compounds , multiple abused drugs , aromatic amines , morphine and its four metabolites , tobacco‐specific N ‐nitrosamines , voriconazole , and so on. Furthermore, Maijó et al developed anion selective exhaustive injection‐sweeping in MEKC for the analysis of nonsteroidal anti‐inflammatory drugs (NSAIDs).…”

Section: Ce On‐line Stackingmentioning

confidence: 99%

“…Another procedure combining FESI with sweeping is called selective exhaustive injection‐sweeping. The optimization of different parameters such as SDS concentration, sample matrix composition, water plug, high‐conductivity buffer (HCB) plug, and sample injection time was performed . So far, the innovation of sweeping technique mainly lies in the exploration of new pseudo‐stationary phases.…”

Section: Ce On‐line Stackingmentioning

confidence: 99%

Recent advances in enrichment techniques for trace analysis in capillary electrophoresis

Wen

et al. 2012

Electrophoresis

111

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Recent advances in enrichment techniques for trace analysis in capillary electrophoresisCE is gaining great popularity as a well-established separation technique for many fields such as pharmaceutical research, clinical application, environmental monitoring, and food analysis, owing to its high resolving power, rapidity, and small amount of samples and reagents required. However, the sensitivity in CE analysis is still considered as being inferior to that in HPLC analysis. Diverse enrichment methods and techniques have been increasingly developed for overcoming this issue. In this review, we summarize the recent advances in enrichment techniques containing off-line preconcentration (sample preparation) and on-line concentration (sample stacking) to enhancing sensitivity in CE for trace analysis over the last 5 years. Some relatively new cleanup and preconcentration methods involving the use of dispersive liquid-liquid microextraction, supercritical fluid extraction, matrix solid-phase dispersion, etc., and the continued use and improvement of conventional SPE, have been comprehensively reviewed and proved effective preconcentration alternatives for liquid, semisolid, and solid samples. As for CE on-line stacking, we give an overview of field amplication, sweeping, pH regulation, and transient isotachophoresis, and the coupling of multiple modes. Moreover, some limitations and comparisons related to such methods/techniques are also discussed. Finally, the combined use of various enrichment techniques and some significant attempts are proposed to further promote analytical merits in CE.

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On-Column Preconcentration of Anti-Inflammatory Drugs in River Water by Anion-Selective Exhaustive Injection-Sweeping-MEKC

Cited by 13 publications

References 31 publications

Micellar electrokinetic chromatography: A review of methodological and instrumental innovations focusing on practical aspects

Micellar electrokinetic chromatography: A review of methodological and instrumental innovations focusing on practical aspects

Recent advances in enhancing the sensitivity of electrophoresis and electrochromatography in capillaries and microchips (2010–2012)

Recent advances in enrichment techniques for trace analysis in capillary electrophoresis

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